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Must Read
F1000 Factor 6.0

New Finding
Tech Advance
 Effects of Branching Architecture and Linker on the Activity of Hyperbranched Polymer-Drug Conjugates.
Perumal O, Khandare J, …, Lieh-Lai M, Kannan RM
Bioconjug Chem 2009 Apr 29 20 [abstract on PubMed] [related articles] [full text]
Selected by | Donald A Tomalia
Evaluated 2 Jul 2009

Recommended
F1000 Factor 3.0

Tech Advance
 A three-dimensional scaffold with precise micro-architecture and surface micro-textures.
Mata A, Kim EJ, …, Muschler GF, Roy S
Biomaterials 2009 Jun 11 [abstract on PubMed] [related articles] [full text]
Selected by | Tejal Desai
Evaluated 24 Jun 2009

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
Controversial
 Inhibitor hijacking of Akt activation.
Okuzumi T, Fiedler D, …, Hoffman R, Shokat KM
Nat Chem Biol 2009 May 24 [abstract on PubMed] [related articles] [full text]
Selected by | Jonathan Chernoff
Evaluated 15 Jun 2009

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
 A novel pregnane X receptor and S14-mediated lipogenic pathway in human hepatocyte.
Moreau A, Téruel C, …, Vilarem MJ, Pascussi JM
Hepatology 2009 Jun 49(6):2068-79 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Bruno Stieger
Evaluated 15 Jun 2009

Recommended
F1000 Factor 3.0

New Finding
 The glucocorticoid receptor heterocomplex gene STIP1 is associated with improved lung function in asthmatic subjects treated with inhaled corticosteroids.
Hawkins GA, Lazarus R, …, Weiss ST, Bleecker ER
J Allergy Clin Immunol 2009 Jun 123(6):1376-83.e7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Mark Spears and Neil Thomson
Evaluated 11 Jun 2009

Must Read
F1000 Factor 6.5

Hypothesis
New Finding
Novel Drug Target
 Enhancing CD8 T-cell memory by modulating fatty acid metabolism.
Pearce EL, Walsh MC, …, Jones RG, Choi Y
Nature 2009 Jun 3 [abstract on PubMed] [related articles] [full text]
Selected by | Allan Zajac / Susan Kaech / John Kyriakis
First evaluation 9 Jun 2009 | Latest evaluation 3 Jul 2009

Recommended
F1000 Factor 3.0

Confirmation
New Finding
Tech Advance
 Engineering antibody fragments to fold in the absence of disulfide bonds.
Seo MJ, Jeong KJ, …, Iverson BL, Georgiou G
Protein Sci 2009 Feb 18(2):259-67 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Nicolas Economopoulos and Sachdev Sidhu
Evaluated 5 Jun 2009

Recommended
F1000 Factor 3.0

New Finding
Novel Drug Target
 Glutaraldehyde-polymerized bovine hemoglobin and phosphodiesterase-5 inhibition.
Gotshall RW, Hamilton KL, …, van Patot MC, Irwin DC
Crit Care Med 2009 Jun 37(6):1988-93 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Max Gassmann
Evaluated 3 Jun 2009

Must Read
F1000 Factor 6.0

Tech Advance
 An agonist-antagonist interaction model for prolactin release following risperidone and paliperidone treatment.
Friberg LE, Vermeulen AM, Petersson KJ, Karlsson MO
Clin Pharmacol Ther 2009 Apr 85(4):409-17 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jonathan Knights and Murali Ramanathan
Evaluated 2 Jun 2009

Exceptional
F1000 Factor 9.0

Hypothesis
 Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humans.
Harrill AH, Watkins PB, …, Rusyn I, Threadgill DW
Genome Res 2009 May 5 [abstract on PubMed] [related articles] [full text]
Selected by | Michael Cunningham
Evaluated 1 Jun 2009


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