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Browse > Pharmacology & Drug Discovery > Pharmacogenomics
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Recommended
F1000 Factor 3.0

New Finding
 Genetic polymorphism of hepatocyte nuclear factor-4alpha influences human cytochrome P450 2D6 activity.
Lee SS, Cha EY, …, Yeo CW, Shin JG
Hepatology 2008 Aug 48(2):635-45 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Bruno Stieger
Evaluated 18 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
Tech Advance
 Anatomical profiling of G protein-coupled receptor expression.
Regard JB, Sato IT, Coughlin SR
Cell 2008 Oct 31 135(3):561-71 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Soeren Sheikh
Evaluated 14 Nov 2008

Recommended
F1000 Factor 3.0

Confirmation
 Genetic variation in human P450 oxidoreductase.
Miller WL, Huang N, Agrawal V, Giacomini KM
Mol Cell Endocrinol 2008 Sep 26 [abstract on PubMed] [related articles] [full text]
Selected by | Magnus Ingelman-Sundberg
Evaluated 4 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
Controversial
 ABCB1 (MDR 1) polymorphisms and progression-free survival among women with ovarian cancer following paclitaxel/carboplatin chemotherapy.
Johnatty SE, Beesley J, …, DeFazio A, Chenevix-Trench G
Clin Cancer Res 2008 Sep 1 14(17):5594-601 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Susan Bates
Evaluated 4 Nov 2008

Recommended
F1000 Factor 3.0

Hypothesis
Novel Drug Target
 Expanding the roles for pregnane X receptor in cancer: proliferation and drug resistance in ovarian cancer.
Gupta D, Venkatesh M, …, Longley C, Mani S
Clin Cancer Res 2008 Sep 1 14(17):5332-40 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Susan Bates
Evaluated 4 Nov 2008

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
Novel Drug Target
 Elimination of Schistosoma mansoni Adult Worms by Rhesus Macaques: Basis for a Therapeutic Vaccine?
Wilson RA, Langermans JA, …, Thomas AW, Coulson PS
PLoS Negl Trop Dis 2008 2(9):e290 [abstract on PubMed] [related articles] [FREE full text]
Selected by | W. Evan Secor
Evaluated 29 Oct 2008

Recommended
F1000 Factor 3.0

Confirmation
New Finding
Novel Drug Target
 Genetic polymorphisms of NAD(P)H oxidase: variation in subunit expression and enzyme activity.
Schirmer M, Hoffmann M, …, Tzvetkov M, Brockmöller J
Pharmacogenomics J 2008 Aug 8(4):297-304 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ines Armando
Evaluated 23 Oct 2008

Recommended
F1000 Factor 3.0

Hypothesis
 The Population Reference Sample, POPRES: a resource for population, disease, and pharmacological genetics research.
Nelson MR, Bryc K, …, Ehm MG, Lai EH
Am J Hum Genet 2008 Sep 83(3):347-58 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Terri Beaty
Evaluated 21 Oct 2008

Must Read
F1000 Factor 6.0

New Finding
Tech Advance
Novel Drug Target
 Off-target effects of psychoactive drugs revealed by genome-wide assays in yeast.
Ericson E, Gebbia M, …, Giaever G, Nislow C
PLoS Genet 2008 4(8):e1000151 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Ramon Serrano
Evaluated 20 Oct 2008

Recommended
F1000 Factor 3.0

Confirmation
Tech Advance
 Genomic signatures and dose-dependent transitions in nasal epithelial responses to inhaled formaldehyde in the rat.
Andersen ME, Clewell HJ, …, Willson GA, Thomas RS
Toxicol Sci 2008 Oct 105(2):368-83 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Bruce Car with Stefan Ruepp
Evaluated 20 Oct 2008


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