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Recommended
F1000 Factor 3.0

New Finding
Tech Advance
 Alternative isoform regulation in human tissue transcriptomes.
Wang ET, Sandberg R, …, Schroth GP, Burge CB
Nature 2008 Nov 2 [abstract on PubMed] [related articles] [full text]
Selected by | Ken Irvine with Yongqiang Feng
Evaluated 20 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
 Association between active genes occurs at nuclear speckles and is modulated by chromatin environment.
Brown JM, Green J, …, Iborra FJ, Buckle VJ
J Cell Biol 2008 Sep 22 182(6):1083-97 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Peter Shaw
Evaluated 18 Nov 2008

Recommended
F1000 Factor 3.0

Hypothesis
 Intestinal gluconeogenesis is a key factor for early metabolic changes after gastric bypass but not after gastric lap-band in mice.
Troy S, Soty M, …, Mithieux G, Andreelli F
Cell Metab 2008 Sep 8(3):201-11 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joel Elmquist with Kevin W. Williams
Evaluated 18 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
 Genetic polymorphism of hepatocyte nuclear factor-4alpha influences human cytochrome P450 2D6 activity.
Lee SS, Cha EY, …, Yeo CW, Shin JG
Hepatology 2008 Aug 48(2):635-45 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Bruno Stieger
Evaluated 18 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
 HSP27 is involved in the pathogenesis of kidney tubulointerstitial fibrosis.
Vidyasagar A, Reese S, …, Hullett D, Djamali A
Am J Physiol Renal Physiol 2008 Sep 295(3):F707-16 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Norma A. Bobadilla
Evaluated 17 Nov 2008


Must Read
F1000 Factor 6.0

New Finding
 Familial pulmonary alveolar proteinosis caused by mutations in CSF2RA.
Suzuki T, Sakagami T, …, van der Loo JC, Trapnell BC
J Exp Med 2008 Oct 27 [abstract on PubMed] [related articles] [full text]
Selected by | Glenn Dranoff
Evaluated 17 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
Tech Advance
 Exploring RNA transcription and turnover in vivo by using click chemistry.
Jao CY, Salic A
Proc Natl Acad Sci U S A 2008 Oct 14 105(41):15779-84 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Michael B. Yaffe
Evaluated 14 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
Tech Advance
 Anatomical profiling of G protein-coupled receptor expression.
Regard JB, Sato IT, Coughlin SR
Cell 2008 Oct 31 135(3):561-71 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Soeren Sheikh
Evaluated 14 Nov 2008

Must Read
F1000 Factor 6.6

Hypothesis
New Finding
 HARP is an ATP-driven annealing helicase.
Yusufzai T, Kadonaga JT
Science 2008 Oct 31 322(5902):748-50 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Michael Botchan / Lucio Comai / Jessica Downs
First evaluation 13 Nov 2008 | Latest evaluation 17 Nov 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
Novel Drug Target
 Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart.
Chen CH, Budas GR, …, Hurley TD, Mochly-Rosen D
Science 2008 Sep 12 321(5895):1493-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Triggle
Evaluated 11 Nov 2008


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