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Browse > Physiology > Gastrointestinal Physiology
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Recommended
F1000 Factor 3.0

Hypothesis
 Intestinal gluconeogenesis is a key factor for early metabolic changes after gastric bypass but not after gastric lap-band in mice.
Troy S, Soty M, …, Mithieux G, Andreelli F
Cell Metab 2008 Sep 8(3):201-11 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joel Elmquist with Kevin W. Williams
Evaluated 18 Nov 2008

Recommended
F1000 Factor 3.0

Confirmation
 Purinergic receptors and synaptic transmission in enteric neurons.
Ren J, Bertrand PP
Purinergic Signal 2008 Sep 4(3):255-66 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Geoffrey Burnstock
Evaluated 14 Nov 2008

Recommended
F1000 Factor 3.0

Hypothesis
Controversial
Novel Drug Target
 Impaired parasympathetic function increases susceptibility to inflammatory bowel disease in a mouse model of depression.
Ghia JE, Blennerhassett P, Collins SM
J Clin Invest 2008 Jun 118(6):2209-18 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Ruud Buijs
Evaluated 14 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
 A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity.
Cella M, Fuchs A, …, Mills JC, Colonna M
Nature 2008 Nov 2 [abstract on PubMed] [related articles] [full text]
Selected by | Mauro Teixeira
Evaluated 10 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
 Reciprocal Changes in Vanilloid (TRPV1) and Endocannabinoid (CB1) Receptors Contribute to Visceral Hyperalgesia in the Water Avoidance Stressed Rat.
Hong S, Fan J, …, Li Y, Wiley JW
Gut 2008 Oct 20 [abstract on PubMed] [related articles] [full text]
Selected by | Yvette Taché
Evaluated 4 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
Novel Drug Target
 Discovery of the first potent and orally efficacious agonist of the orphan G-protein coupled receptor 119.
Semple G, Fioravanti B, …, Leonard J, Jones RM
J Med Chem 2008 Sep 11 51(17):5172-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Roger Freidinger
Evaluated 31 Oct 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
Novel Drug Target
 Transient receptor potential vanilloid-4 has a major role in visceral hypersensitivity symptoms.
Cenac N, Altier C, …, Zamponi G, Vergnolle N
Gastroenterology 2008 Sep 135(3):937-46, 946.e1-2 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Indu Ambudkar
Evaluated 29 Oct 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
 Secreted bioactive factors from Bifidobacterium infantis enhance epithelial cell barrier function.
Ewaschuk JB, Diaz H, …, Looijer-van Langen M, Madsen KL
Am J Physiol Gastrointest Liver Physiol 2008 Sep 11 [abstract on PubMed] [related articles] [full text]
Selected by | Helen Raybould
Evaluated 29 Oct 2008

Exceptional
F1000 Factor 8.0

New Finding
 Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine.
Ivanov II, Frutos Rde L, …, Finlay BB, Littman DR
Cell Host Microbe 2008 Oct 16 4(4):337-49 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Klaus Ley / David Underhill
First evaluation 24 Oct 2008 | Latest evaluation 30 Oct 2008

Recommended
F1000 Factor 3.0

Tech Advance
 Modulation of peripheral serotonin levels by novel tryptophan hydroxylase inhibitors for the potential treatment of functional gastrointestinal disorders.
Shi ZC, Devasagayaraj A, …, Wilson A, Liu Q
J Med Chem 2008 Jul 10 51(13):3684-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Thomas W. von Geldern
Evaluated 23 Oct 2008


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