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Must Read
F1000 Factor 6.0

Hypothesis
New Finding
 The histone variant H3.3 regulates gene expression during lytic infection by Herpes Simplex Virus, HSV-1.
Placek BJ, Huang J, …, Fraser NW, Berger SL
J Virol 2008 Nov 12 [abstract on PubMed] [related articles] [full text]
Selected by | Jim Smiley
Evaluated 21 Nov 2008

Recommended
F1000 Factor 3.0

Confirmation
New Finding
 Increased avian diversity is associated with lower incidence of human West Nile infection: observation of the dilution effect.
Swaddle JP, Calos SE
PLoS ONE 2008 3(6):e2488 [abstract on PubMed] [related articles] [FREE full text]
Selected by | J. Emmett Duffy
Evaluated 19 Nov 2008

Recommended
F1000 Factor 3.0

Hypothesis
 Stimulation of Ebola virus production from persistent infection through activation of the Ras/MAPK pathway.
Strong JE, Wong G, …, Kobinger GP, Feldmann H
Proc Natl Acad Sci U S A 2008 Nov 3 105 [abstract on PubMed] [related articles] [full text]
Selected by | Kanta Subbarao with Catherine Luke
Evaluated 19 Nov 2008

Recommended
F1000 Factor 3.0

Confirmation
Hypothesis
New Finding
 Vaccinia virus anti-apoptotic F1L is a novel Bcl-2-like domain-swapped dimer that binds a highly selective subset of BH3-containing death ligands.
Kvansakul M, Yang H, …, Huang DC, Colman PM
Cell Death Differ 2008 Oct 15(10):1564-71 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Andrews
Evaluated 18 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
 Primary infection with simian immunodeficiency virus: plasmacytoid dendritic cell homing to lymph nodes, type I IFN, and immune suppression.
Malleret B, Maneglier B, …, Le Grand R, Vaslin B
Blood 2008 Sep 11 [abstract on PubMed] [related articles] [full text]
Selected by | Gene Shearer with Adriano Boasso
Evaluated 18 Nov 2008

Must Read
F1000 Factor 4.8

Hypothesis
New Finding
Controversial
 Memory CD8 T-cell compartment grows in size with immunological experience.
Vezys V, Yates A, …, Antia R, Masopust D
Nature 2008 Nov 12 [abstract on PubMed] [related articles] [full text]
Selected by | Barry Rouse / Michael McChesney
First evaluation 18 Nov 2008 | Latest evaluation 21 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
 X-ray structure of NS1 from a highly pathogenic H5N1 influenza virus.
Bornholdt ZA, Prasad BV
Nature 2008 Nov 5 [abstract on PubMed] [related articles] [full text]
Selected by | Samuel Butcher
Evaluated 13 Nov 2008

Recommended
F1000 Factor 3.2

New Finding
Tech Advance
Novel Drug Target
 Engineering microRNA responsiveness to decrease virus pathogenicity.
Kelly EJ, Hadac EM, Greiner S, Russell SJ
Nat Med 2008 Nov 14(11):1278-83 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | James Crowe / Lynne Maquat with Olaf Isken
First evaluation 12 Nov 2008 | Latest evaluation 19 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
Tech Advance
 Single-particle kinetics of influenza virus membrane fusion.
Floyd DL, Ragains JR, …, Harrison SC, van Oijen AM
Proc Natl Acad Sci U S A 2008 Oct 7 105(40):15382-7 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Lukas Tamm with Volker Kiessling
Evaluated 10 Nov 2008

Recommended
F1000 Factor 3.0

Confirmation
New Finding
Tech Advance
 Dynamics of human respiratory virus-specific CD8+ T cell responses in blood and airways during episodes of common cold.
Heidema J, Rossen JW, …, Kimpen JL, van Bleek GM
J Immunol 2008 Oct 15 181(8):5551-9 [abstract on PubMed] [related articles] [order article]
Selected by | Peter Openshaw
Evaluated 10 Nov 2008


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