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Exceptional
F1000 Factor 9.0

New Finding
Tech Advance
The establishment of gene silencing at single-cell resolution.
Osborne EA, Dudoit S, Rine J
Nat Genet 2009 Jul 41(7):800-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Fyodor Urnov
Evaluated 2 Jul 2009

Exceptional
F1000 Factor 9.0

New Finding
Tech Advance
Reconstitution of Rab- and SNARE-dependent membrane fusion by synthetic endosomes.
Ohya T, Miaczynska M, …, Kalaidzidis Y, Zerial M
Nature 2009 Jun 25 459(7250):1091-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Josep Rizo
Evaluated 30 Jun 2009

Must Read
F1000 Factor 6.0

New Finding
Structural mechanism of substrate RNA recruitment in H/ACA RNA-guided pseudouridine synthase.
Duan J, Li L, …, Wang W, Ye K
Mol Cell 2009 May 14 34(4):427-39 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Eric Westhof
Evaluated 29 Jun 2009

Recommended
F1000 Factor 3.0

New Finding
Structure of rotavirus outer-layer protein VP7 bound with a neutralizing Fab.
Aoki ST, Settembre EC, …, Harrison SC, Dormitzer PR
Science 2009 Jun 12 324(5933):1444-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | James Crowe
Evaluated 26 Jun 2009

Recommended
F1000 Factor 3.0

Hypothesis
An unfolded CH1 domain controls the assembly and secretion of IgG antibodies.
Feige MJ, Groscurth S, …, Hendershot LM, Buchner J
Mol Cell 2009 Jun 12 34(5):569-79 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Robert Kelley
Evaluated 26 Jun 2009

Must Read
F1000 Factor 6.0

New Finding
Structural basis for DNA binding by replication initiator Mcm10.
Warren EM, Vaithiyalingam S, …, Chazin WJ, Eichman BF
Structure 2008 Dec 10 16(12):1892-901 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Sylvie Doublie
Evaluated 26 Jun 2009

Must Read
F1000 Factor 6.0

Confirmation
Hypothesis
New Finding
Egalitarian is a selective RNA-binding protein linking mRNA localization signals to the dynein motor.
Dienstbier M, Boehl F, Li X, Bullock SL
Genes Dev 2009 Jun 10 [abstract on PubMed] [related articles] [full text]
Selected by | Anna Akhmanova
Evaluated 26 Jun 2009

Recommended
F1000 Factor 3.0

Confirmation
New Finding
Role of kinesin-1 and cytoplasmic dynein in endoplasmic reticulum movement in VERO cells.
Wozniak MJ, Bola B, …, Levakova V, Allan VJ
J Cell Sci 2009 Jun 15 122(Pt 12):1979-89 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Anna Akhmanova
Evaluated 26 Jun 2009

Recommended
F1000 Factor 3.0

Hypothesis
The Core Signaling Proteins of Bacterial Chemotaxis Assemble To Form an Ultrastable Complex.
Erbse AH, Falke JJ
Biochemistry 2009 Jun 15 [abstract on PubMed] [related articles] [full text]
Selected by | George Ordal
Evaluated 25 Jun 2009

Must Read
F1000 Factor 6.0

New Finding
Multiple assembly chaperones govern biogenesis of the proteasome regulatory particle base.
Funakoshi M, Tomko RJ, Kobayashi H, Hochstrasser M
Cell 2009 May 29 137(5):887-99 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Michael Rape
Evaluated 24 Jun 2009


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