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Recommended
F1000 Factor 3.0

New Finding
Controversial
 The transcriptional repressor protein NsrR senses nitric oxide directly via a [2Fe-2S] cluster.
Tucker NP, Hicks MG, …, Dixon R, Hutchings MI
PLoS ONE 2008 3(11):e3623 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Stephen Spiro
Evaluated 18 Nov 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
 A Role for the ESCRT System in Cell Division in Archaea.
Samson RY, Obita T, …, Williams RL, Bell SD
Science 2008 Nov 13 [abstract on PubMed] [related articles] [full text]
Selected by | Linda Amos
Evaluated 17 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
 Bacterial biosynthesis of a multipotent stilbene.
Joyce SA, Brachmann AO, …, Clarke DJ, Bode HB
Angew Chem Int Ed Engl 2008 47(10):1942-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Barrie Wilkinson
Evaluated 17 Nov 2008

Must Read
F1000 Factor 6.5

Hypothesis
New Finding
 A unique cell division machinery in the Archaea.
Lindås AC, Karlsson EA, …, Ettema TJ, Bernander R
Proc Natl Acad Sci U S A 2008 Nov 5 [abstract on PubMed] [related articles] [full text]
Selected by | William Margolin / Linda Amos / Harold Erickson
First evaluation 13 Nov 2008 | Latest evaluation 18 Nov 2008

Recommended
F1000 Factor 3.2

New Finding
Tech Advance
Novel Drug Target
 Engineering microRNA responsiveness to decrease virus pathogenicity.
Kelly EJ, Hadac EM, Greiner S, Russell SJ
Nat Med 2008 Nov 14(11):1278-83 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | James Crowe / Lynne Maquat with Olaf Isken
First evaluation 12 Nov 2008 | Latest evaluation 19 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
 Group A human rotavirus genomics: evidence that gene constellations are influenced by viral protein interactions.
Heiman EM, McDonald SM, …, Bar-Magen T, Patton JT
J Virol 2008 Nov 82(22):11106-16 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Lynn Enquist
Evaluated 10 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
 HilD-mediated transcriptional cross-talk between SPI-1 and SPI-2.
Bustamante VH, Martínez LC, …, Steele-Mortimer O, Puente JL
Proc Natl Acad Sci U S A 2008 Sep 23 105(38):14591-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Charles J. Dorman
Evaluated 6 Nov 2008

Recommended
F1000 Factor 3.0

Hypothesis
 Rethinking early Earth phosphorus geochemistry.
Pasek MA
Proc Natl Acad Sci U S A 2008 Jan 22 105(3):853-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | John Coates
Evaluated 3 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
Tech Advance
 Rapid Virulence Annotation (RVA): identification of virulence factors using a bacterial genome library and multiple invertebrate hosts.
Waterfield NR, Sanchez-Contreras M, …, Dorus S, Ffrench-Constant RH
Proc Natl Acad Sci U S A 2008 Oct 14 105(41):15967-72 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Leo Eberl
Evaluated 31 Oct 2008

Must Read
F1000 Factor 4.8

Hypothesis
New Finding
Tech Advance
 A stochastic single-molecule event triggers phenotype switching of a bacterial cell.
Choi PJ, Cai L, Frieda K, Xie XS
Science 2008 Oct 17 322(5900):442-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | James Moir with Andrew Schofield / Jim Maher
First evaluation 29 Oct 2008 | Latest evaluation 5 Nov 2008


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