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Browse > Immunology > Genetics of the Immune System
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Must Read
F1000 Factor 6.0

New Finding
 Regulation of hierarchical clustering and activation of innate immune cells by dendritic cells.
Kang SJ, Liang HE, Reizis B, Locksley RM
Immunity 2008 Nov 29(5):819-33 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jenny Ting
Evaluated 1 Dec 2008

Must Read
F1000 Factor 6.0

New Finding
 FADD and caspase-8 control the outcome of autophagic signaling in proliferating T cells.
Bell BD, Leverrier S, …, Morrissette NS, Walsh CM
Proc Natl Acad Sci U S A 2008 Oct 28 105(43):16677-82 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Astar Winoto
Evaluated 28 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
 Novel genes dramatically alter regulatory network topology in amphioxus.
Zhang Q, Zmasek CM, …, Litman GW, Godzik A
Genome Biol 2008 9(8):R123 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Tony De Tomaso
Evaluated 26 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
 Familial pulmonary alveolar proteinosis caused by mutations in CSF2RA.
Suzuki T, Sakagami T, …, van der Loo JC, Trapnell BC
J Exp Med 2008 Oct 27 [abstract on PubMed] [related articles] [full text]
Selected by | Glenn Dranoff
Evaluated 17 Nov 2008

Must Read
F1000 Factor 6.6

Hypothesis
New Finding
 HARP is an ATP-driven annealing helicase.
Yusufzai T, Kadonaga JT
Science 2008 Oct 31 322(5902):748-50 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Michael Botchan / Lucio Comai / Jessica Downs
First evaluation 13 Nov 2008 | Latest evaluation 17 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
Novel Drug Target
 Alternate mRNA splicing in multiple human tryptase genes is predicted to regulate tetramer formation.
Jackson NE, Wang HW, …, Cairns J, Hunt JE
J Biol Chem 2008 Oct 14 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Richard L. Stevens
Evaluated 13 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
 Substrains of 129 mice are resistant to Yersinia pestis KIM5: Implications for IL-10 deficient mice.
Turner JK, Xu JL, Tapping RI
Infect Immun 2008 Oct 27 [abstract on PubMed] [related articles] [full text]
Selected by | James Bliska
Evaluated 11 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
Novel Drug Target
 T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance.
Pesu M, Watford WT, …, Creemers J, O'Shea JJ
Nature 2008 Sep 11 455(7210):246-50 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Robert Fuller
Evaluated 10 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
 Murine IL-4 is able to signal via chimeric human IL-4Ralpha/mouse gamma-chain receptor.
Myburgh E, Horsnell WG, …, Kubo M, Brombacher F
Mol Immunol 2008 Mar 45(5):1327-36 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Achsah Keegan with Nicola M. Heller
Evaluated 5 Nov 2008

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
 TLR3 is an endogenous sensor of tissue necrosis during acute inflammatory events.
Cavassani KA, Ishii M, …, Hogaboam CM, Kunkel SL
J Exp Med 2008 Oct 27 205(11):2609-21 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Takeshi Tsubata
Evaluated 4 Nov 2008



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