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Must Read
F1000 Factor 6.0

Hypothesis
New Finding
Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance.
Nedjic J, Aichinger M, …, Mizushima N, Klein L
Nature 2008 Aug 13 [abstract on PubMed] [related articles] [full text]
Selected by | Vojo Deretic
Evaluated 27 Aug 2008

Recommended
F1000 Factor 3.0

Confirmation
Autoreactive marginal zone B cells are spontaneously activated but lymph node B cells require T cell help.
Mandik-Nayak L, Racz J, Sleckman BP, Allen PM
J Exp Med 2006 Aug 7 203(8):1985-98 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Antony Basten with Pablo Silveira
Evaluated 21 Aug 2008

Recommended
F1000 Factor 3.0

New Finding
TGF-beta signaling in thymic epithelial cells regulates thymic involution and postirradiation reconstitution.
Hauri-Hohl MM, Zuklys S, …, Roes J, Holländer GA
Blood 2008 Aug 1 112(3):626-34 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Mohamed Sayegh with Jessamyn Bagley
Evaluated 20 Aug 2008

Recommended
F1000 Factor 3.0

Confirmation
New Finding
ADAMTS13: a new link between thrombosis and inflammation.
Chauhan AK, Kisucka J, …, Scheiflinger F, Wagner DD
J Exp Med 2008 Aug 11 [abstract on PubMed] [related articles] [full text]
Selected by | William A Muller
Evaluated 19 Aug 2008

Must Read
F1000 Factor 6.4

New Finding
Deletional tolerance mediated by extrathymic Aire-expressing cells.
Gardner JM, Devoss JJ, …, Krummel MF, Anderson MS
Science 2008 Aug 8 321(5890):843-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Peter Van Endert / Torben Lund
First evaluation 18 Aug 2008 | Latest evaluation 19 Aug 2008


Recommended
F1000 Factor 3.0

New Finding
Controversial
In vitro differentiation of dendritic cells in the presence of prostaglandin E2 alters the IL-12/IL-23 balance and promotes differentiation of Th17 cells.
Khayrullina T, Yen JH, Jing H, Ganea D
J Immunol 2008 Jul 1 181(1):721-35 [abstract on PubMed] [related articles] [order article]
Selected by | Klaus Ley
Evaluated 13 Aug 2008

Recommended
F1000 Factor 3.0

New Finding
Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages.
Nurieva RI, Chung Y, …, Tian Q, Dong C
Immunity 2008 Jul 29(1):138-49 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Toshinori Nakayama with Motoko Kimura
Evaluated 12 Aug 2008

Must Read
F1000 Factor 6.0

New Finding
Continuous engagement of a self-specific activation receptor induces NK cell tolerance.
Tripathy SK, Keyel PA, …, Schneeberger A, Yokoyama WM
J Exp Med 2008 Jul 7 [abstract on PubMed] [related articles] [full text]
Selected by | Eric Vivier
Evaluated 7 Aug 2008

Must Read
F1000 Factor 6.0

New Finding
Tolerance of NK cells encountering their viral ligand during development.
Sun JC, Lanier LL
J Exp Med 2008 Jul 7 [abstract on PubMed] [related articles] [full text]
Selected by | Eric Vivier
Evaluated 7 Aug 2008

Must Read
F1000 Factor 6.0

Confirmation
New Finding
Regulation of B cell fate commitment and immunoglobulin heavy-chain gene rearrangements by Ikaros.
Reynaud D, Demarco IA, …, Winandy S, Singh H
Nat Immunol 2008 Aug 9(8):927-36 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Pierre Ferrier
Evaluated 31 Jul 2008


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