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Must Read
F1000 Factor 6.0

Tech Advance
Novel Drug Target
 Chemical control of protein stability and function in living mice.
Banaszynski LA, Sellmyer MA, …, Wandless TJ, Thorne SH
Nat Med 2008 Oct 14(10):1123-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ken Irvine with Yongqiang Feng
Evaluated 20 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
 Temporal requirement of the alternative-splicing factor Sfrs1 for the survival of retinal neurons.
Kanadia RN, Clark VE, …, Trimarchi JM, Cepko CL
Development 2008 Dec 135(23):3923-33 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Reinhard Luehrmann
Evaluated 20 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
 Association between active genes occurs at nuclear speckles and is modulated by chromatin environment.
Brown JM, Green J, …, Iborra FJ, Buckle VJ
J Cell Biol 2008 Sep 22 182(6):1083-97 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Peter Shaw
Evaluated 18 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
 Persistent epigenetic differences associated with prenatal exposure to famine in humans.
Heijmans BT, Tobi EW, …, Slagboom PE, Lumey LH
Proc Natl Acad Sci U S A 2008 Nov 4 105(44):17046-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Wolf Reik
Evaluated 18 Nov 2008

Recommended
F1000 Factor 3.0

Hypothesis
 Intestinal gluconeogenesis is a key factor for early metabolic changes after gastric bypass but not after gastric lap-band in mice.
Troy S, Soty M, …, Mithieux G, Andreelli F
Cell Metab 2008 Sep 8(3):201-11 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joel Elmquist with Kevin W. Williams
Evaluated 18 Nov 2008

Recommended
F1000 Factor 3.0

Confirmation
 Paracrine regulation of the epithelial Na+ channel in the mammalian collecting duct by purinergic P2Y2 receptor tone.
Pochynyuk O, Bugaj V, …, Vallon V, Stockand JD
J Biol Chem 2008 Nov 3 [abstract on PubMed] [related articles] [FREE full text]
Selected by | William Welch
Evaluated 17 Nov 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
 Polycomb proteins targeted by a short repeat RNA to the mouse X chromosome.
Zhao J, Sun BK, …, Song JJ, Lee JT
Science 2008 Oct 31 322(5902):750-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Brad Bernstein
Evaluated 17 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
Tech Advance
 Homing of mouse spermatogonial stem cells to germline niche depends on beta1-integrin.
Kanatsu-Shinohara M, Takehashi M, …, Fässler R, Shinohara T
Cell Stem Cell 2008 Nov 6 3(5):533-42 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Erika Matunis
Evaluated 13 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
 TAp73 knockout shows genomic instability with infertility and tumor suppressor functions.
Tomasini R, Tsuchihara K, …, Jurisicova A, Mak TW
Genes Dev 2008 Oct 1 22(19):2677-91 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Rong Li with Giulia Rancati
Evaluated 12 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
Novel Drug Target
 Discovery of 1,4-substituted piperidines as potent and selective inhibitors of T-type calcium channels.
Yang ZQ, Barrow JC, …, Koblan KS, Renger JJ
J Med Chem 2008 Oct 23 51(20):6471-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Triggle
Evaluated 12 Nov 2008


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