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Recommended
F1000 Factor 3.0

New Finding
Association between active genes occurs at nuclear speckles and is modulated by chromatin environment.
Brown JM, Green J, …, Iborra FJ, Buckle VJ
J Cell Biol 2008 Sep 22 182(6):1083-97 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Peter Shaw
Evaluated 18 Nov 2008

Must Read
F1000 Factor 6.0

Confirmation
Hypothesis
Genome-wide linkage analysis of multiple measures of neuroticism of 2 large cohorts from Australia and the Netherlands.
Wray NR, Middeldorp CM, …, Martin NG, Boomsma DI
Arch Gen Psychiatry 2008 Jun 65(6):649-58 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ian Deary with Lorna Houlihan
Evaluated 18 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
Persistent epigenetic differences associated with prenatal exposure to famine in humans.
Heijmans BT, Tobi EW, …, Slagboom PE, Lumey LH
Proc Natl Acad Sci U S A 2008 Nov 4 105(44):17046-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Wolf Reik
Evaluated 18 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
Genetic polymorphism of hepatocyte nuclear factor-4alpha influences human cytochrome P450 2D6 activity.
Lee SS, Cha EY, …, Yeo CW, Shin JG
Hepatology 2008 Aug 48(2):635-45 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Bruno Stieger
Evaluated 18 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
Gerodermia osteodysplastica is caused by mutations in SCYL1BP1, a Rab-6 interacting golgin.
Hennies HC, Kornak U, …, Wieacker P, Mundlos S
Nat Genet 2008 Nov 9 [abstract on PubMed] [related articles] [full text]
Selected by | Peter McPherson
Evaluated 18 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
Familial pulmonary alveolar proteinosis caused by mutations in CSF2RA.
Suzuki T, Sakagami T, …, van der Loo JC, Trapnell BC
J Exp Med 2008 Oct 27 [abstract on PubMed] [related articles] [full text]
Selected by | Glenn Dranoff
Evaluated 17 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
Human DNA polymerase iota protects cells against oxidative stress.
Petta TB, Nakajima S, …, Yasui A, Kannouche P
EMBO J 2008 Nov 5 27(21):2883-95 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Alan Lehmann
Evaluated 13 Nov 2008

Must Read
F1000 Factor 6.6

Hypothesis
New Finding
HARP is an ATP-driven annealing helicase.
Yusufzai T, Kadonaga JT
Science 2008 Oct 31 322(5902):748-50 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Michael Botchan / Lucio Comai / Jessica Downs
First evaluation 13 Nov 2008 | Latest evaluation 17 Nov 2008

Recommended
F1000 Factor 3.2

New Finding
Tech Advance
Novel Drug Target
Engineering microRNA responsiveness to decrease virus pathogenicity.
Kelly EJ, Hadac EM, Greiner S, Russell SJ
Nat Med 2008 Nov 14(11):1278-83 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | James Crowe / Lynne Maquat with Olaf Isken
First evaluation 12 Nov 2008 | Latest evaluation 19 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
Novel Drug Target
Discovery of 1,4-substituted piperidines as potent and selective inhibitors of T-type calcium channels.
Yang ZQ, Barrow JC, …, Koblan KS, Renger JJ
J Med Chem 2008 Oct 23 51(20):6471-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Triggle
Evaluated 12 Nov 2008


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