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Must Read
F1000 Factor 6.0

New Finding
 Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex.
Yamamoto S, Nishimura O, …, Tarui H, Sasaki H
Dev Cell 2008 Jul 15(1):23-36 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Herbert Steinbeisser
Evaluated 3 Oct 2008

Recommended
F1000 Factor 3.0

New Finding
 CCL5-mediated T-cell chemotaxis involves the initiation of mRNA translation through mTOR/4E-BP1.
Murooka TT, Rahbar R, Platanias LC, Fish EN
Blood 2008 May 15 111(10):4892-901 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Dennis Taub
Evaluated 2 Oct 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
Novel Drug Target
 PIP3-independent activation of TorC2 and PKB at the cell's leading edge mediates chemotaxis.
Kamimura Y, Xiong Y, …, Bolourani P, Devreotes PN
Curr Biol 2008 Jul 22 18(14):1034-43 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Orion Weiner
Evaluated 2 Oct 2008

Recommended
F1000 Factor 3.0

New Finding
 Quantitative analysis of microtubule dynamics during adhesion-mediated growth cone guidance.
Lee AC, Suter DM
Dev Neurobiol 2008 Oct 68(12):1363-77 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | William Harris
Evaluated 1 Oct 2008

Recommended
F1000 Factor 3.0

New Finding
 Circulating blood cells function as a surveillance system for damaged tissue in Drosophila larvae.
Babcock DT, Brock AR, …, Krasnow MA, Galko MJ
Proc Natl Acad Sci U S A 2008 Jul 22 105(29):10017-22 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Paul Martin
Evaluated 30 Sep 2008

Recommended
F1000 Factor 3.0

Confirmation
Hypothesis
Controversial
 A perivascular origin for mesenchymal stem cells in multiple human organs.
Crisan M, Yap S, …, Huard J, Péault B
Cell Stem Cell 2008 Sep 11 3(3):301-13 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Kenneth Gross
Evaluated 30 Sep 2008

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
 Genetic control of cell morphogenesis during Drosophila melanogaster cardiac tube formation.
Medioni C, Astier M, …, Jagla K, Sémériva M
J Cell Biol 2008 Jul 28 182(2):249-61 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Salim Abdelilah-Seyfried
Evaluated 30 Sep 2008

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
 Repulsion by Slit and Roundabout prevents Shotgun/E-cadherin-mediated cell adhesion during Drosophila heart tube lumen formation.
Santiago-Martínez E, Soplop NH, Patel R, Kramer SG
J Cell Biol 2008 Jul 28 182(2):241-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Salim Abdelilah-Seyfried
Evaluated 30 Sep 2008

Recommended
F1000 Factor 3.0

New Finding
Tech Advance
 An innate immune response of blood cells to tumors and tissue damage in Drosophila.
Pastor-Pareja JC, Wu M, Xu T
Dis Models Mech 2008 1:144-154 [full text]
Selected by | Paul Martin
Evaluated 30 Sep 2008

Recommended
F1000 Factor 3.0

New Finding
 The DHHC Palmitoyltransferase Approximated Regulates Fat Signaling and Dachs Localization and Activity.
Matakatsu H, Blair SS
Curr Biol 2008 Sep 23 18(18):1390-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ken Irvine
Evaluated 30 Sep 2008


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