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20-Nov-2008

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	Recommended
F1000 Factor 3.0

Tech Advance

Novel Drug Target

Generating Arrays with High Content and Minimal Consumption of Functional Membrane Proteins.
Majd S, Mayer M
J Am Chem Soc 2008 Nov 1 0 [abstract on PubMed] [related articles] [full text]

Selected by | Ross Weatherman

Evaluated 17 Nov 2008

	Recommended
F1000 Factor 3.0

New Finding

Tech Advance

Seleninate in place of phosphate: irreversible inhibition of protein tyrosine phosphatases.
Abdo M, Liu S, …, Knapp S, Zhang ZY
J Am Chem Soc 2008 Oct 8 130(40):13196-7 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Philip Cole

Evaluated 14 Nov 2008

	Must Read
F1000 Factor 6.0

Hypothesis

Refutation

Novel Drug Target

Anionic charge is prioritized over geometry in aluminum and magnesium fluoride transition state analogs of phosphoryl transfer enzymes.
Baxter NJ, Blackburn GM, …, Wemmer DE, Waltho JP
J Am Chem Soc 2008 Mar 26 130(12):3952-8 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Arieh Warshel with Shina Caroline Lynn Kamerlin

Evaluated 13 Nov 2008

	Recommended
F1000 Factor 3.0

Hypothesis

Motifs for molecular recognition exploiting hydrophobic enclosure in protein-ligand binding.
Young T, Abel R, …, Berne BJ, Friesner RA
Proc Natl Acad Sci U S A 2007 Jan 16 104(3):808-13 [abstract on PubMed] [related articles] [FREE full text]

Selected by | John Proudfoot
Evaluated 29 Oct 2008

	Must Read
F1000 Factor 6.0

New Finding

Tech Advance

Novel Drug Target

Targeted Single-Wall Carbon Nanotube-Mediated Pt(IV) Prodrug Delivery Using Folate as a Homing Device
Dhar S, Liu Z, …, Dai H, Lippard SJ
Journal of the American Chemical Society 2008 130:11467-11476 [full text]

Selected by | James Cowan
Evaluated 27 Oct 2008

	Recommended
F1000 Factor 3.0

Hypothesis

New Finding

The redox environment in the mitochondrial intermembrane space is maintained separately from the cytosol and matrix.
Hu J, Dong L, Outten CE
J Biol Chem 2008 Oct 24 283(43):29126-34 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Lawrence Lash
Evaluated 27 Oct 2008

	Recommended
F1000 Factor 3.0

New Finding

Tech Advance

A ratiometric fluorescent probe based on FRET for imaging Hg2+ ions in living cells.
Zhang X, Xiao Y, Qian X
Angew Chem Int Ed Engl 2008 47(42):8025-9 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Amy Barrios with Divya Krishnamurthy
Evaluated 23 Oct 2008

	Recommended
F1000 Factor 3.0

New Finding

The Promiscuity of beta-Strand Pairing Allows for Rational Design of beta-Sheet Face Inversion.
Makabe K, Koide S
J Am Chem Soc 2008 Oct 9 [abstract on PubMed] [related articles] [full text]

Selected by | H Jane Dyson with Gira Bhabha
Evaluated 23 Oct 2008

	Must Read
F1000 Factor 6.0

New Finding

Tech Advance

Design of Peptide Inhibitors for the Importin alpha/beta Nuclear Import Pathway by Activity-Based Profiling.
Kosugi S, Hasebe M, …, Tomita M, Yanagawa H
Chem Biol 2008 Sep 22 15(9):940-949 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Hening Lin
Evaluated 21 Oct 2008

	Must Read
F1000 Factor 4.8

New Finding

Novel Drug Target

The pathogen protein EspF(U) hijacks actin polymerization using mimicry and multivalency.
Sallee NA, Rivera GM, …, Mayer BJ, Lim WA
Nature 2008 Aug 21 454(7207):1005-8 [abstract on PubMed] [related articles] [full text] [order article]

Selected by | Raphael Valdivia / Ed Manser with Zhao Zhuoshen
First evaluation 14 Oct 2008 | Latest evaluation 22 Oct 2008

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