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F1000 Factor 3.0

New Finding
JunB protects against myeloid malignancies by limiting hematopoietic stem cell proliferation and differentiation without affecting self-renewal.
Santaguida M, Schepers K, …, Braun BS, Passegué E
Cancer Cell 2009 Apr 7 15(4):341-52 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | R. Katherine Hyde and Paul Liu
Evaluated 3 Jul 2009

Exceptional
F1000 Factor 9.0

New Finding
Tech Advance
The establishment of gene silencing at single-cell resolution.
Osborne EA, Dudoit S, Rine J
Nat Genet 2009 Jul 41(7):800-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Fyodor Urnov
Evaluated 2 Jul 2009

Must Read
F1000 Factor 6.0

New Finding
Cytokine/Jak/Stat signaling mediates regeneration and homeostasis in the Drosophila midgut.
Jiang H, Patel PH, …, McEwen DG, Edgar BA
Cell 2009 Jun 26 137(7):1343-55 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Yukiko Yamashita
Evaluated 2 Jul 2009

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
DnaAcos hyperinitiates by circumventing regulatory pathways that control the frequency of initiation in Escherichia coli.
Felczak MM, Kaguni JM
Mol Microbiol 2009 Jun 72(6):1348-63 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martin Marinus
Evaluated 1 Jul 2009

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
Female meiotic sex chromosome inactivation in chicken.
Schoenmakers S, Wassenaar E, …, Grootegoed JA, Baarends WM
PLoS Genet 2009 May 5(5):e1000466 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Carmen Sapienza
Evaluated 1 Jul 2009

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
Specific genomic sequences of E. coli promote replicational initiation by directly reactivating ADP-DnaA.
Fujimitsu K, Senriuchi T, Katayama T
Genes Dev 2009 May 15 23(10):1221-33 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martin Marinus
Evaluated 30 Jun 2009

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
Nuclear transport factor directs localization of protein synthesis during mitosis.
van den Bogaart G, Meinema AC, …, Veenhoff LM, Poolman B
Nat Cell Biol 2009 Mar 11(3):350-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Timothy A. Bolger and Susan Wente
Evaluated 30 Jun 2009

Recommended
F1000 Factor 3.0

New Finding
Tech Advance
Functional overlap of microtubule assembly factors in chromatin-promoted spindle assembly.
Groen AC, Maresca TJ, …, Salmon ED, Mitchison TJ
Mol Biol Cell 2009 Jun 20(11):2766-73 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Adam Williamson and Michael Rape
Evaluated 29 Jun 2009

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
Mutations in smooth muscle alpha-actin (ACTA2) cause coronary artery disease, stroke, and Moyamoya disease, along with thoracic aortic disease.
Guo DC, Papke CL, …, Buja LM, Milewicz DM
Am J Hum Genet 2009 May 84(5):617-27 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Giulio Gabbiani
Evaluated 29 Jun 2009

Recommended
F1000 Factor 3.0

New Finding
Pre-micro RNA signatures delineate stages of endothelial cell transformation in Kaposi sarcoma.
O'Hara AJ, Chugh P, …, Damania B, Dittmer DP
PLoS Pathog 2009 Apr 5(4):e1000389 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Liguo Wu and Lindsey Hutt-Fletcher
Evaluated 26 Jun 2009


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