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Recommended
F1000 Factor 3.0

New Finding
A role for mammalian Sin3 in permanent gene silencing.
van Oevelen C, Wang J, …, Kluger Y, Dynlacht BD
Mol Cell 2008 Nov 7 32(3):359-70 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Paul Kaufman
Evaluated 2 Dec 2008

Recommended
F1000 Factor 3.0

New Finding
Replication fork movement sets chromatin loop size and origin choice in mammalian cells.
Courbet S, Gay S, …, Brison O, Debatisse M
Nature 2008 Sep 25 455(7212):557-60 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Anindya Dutta
Evaluated 1 Dec 2008

Recommended
F1000 Factor 3.0

New Finding
Telomerase recruitment by the telomere end binding protein-beta facilitates G-quadruplex DNA unfolding in ciliates.
Paeschke K, Juranek S, …, Rhodes D, Lipps HJ
Nat Struct Mol Biol 2008 Jun 15(6):598-604 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Makoto Komiyama with Yan Xu
Evaluated 27 Nov 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
Noncoding Transcription by RNA Polymerase Pol IVb/Pol V Mediates Transcriptional Silencing of Overlapping and Adjacent Genes.
Wierzbicki AT, Haag JR, Pikaard CS
Cell 2008 Nov 14 135(4):635-48 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | John Abrams
Evaluated 26 Nov 2008

Must Read
F1000 Factor 6.0

New Finding
Sequence variant on 8q24 confers susceptibility to urinary bladder cancer.
Kiemeney LA, Thorlacius S, …, Rafnar T, Stefansson K
Nat Genet 2008 Nov 40(11):1307-12 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Michael Cole with Jason B. Wright and Seth J. Brown
Evaluated 26 Nov 2008


Must Read
F1000 Factor 6.0

Hypothesis
De Novo Formation of a Subnuclear Body.
Kaiser TE, Intine RV, Dundr M
Science 2008 Oct 23 [abstract on PubMed] [related articles] [full text]
Selected by | Jonathan Chubb
Evaluated 26 Nov 2008

Exceptional
F1000 Factor 9.0

New Finding
Tech Advance
Structure of the intact PPAR-gamma-RXR-alpha nuclear receptor complex on DNA.
Chandra V, Huang P, …, Burris TP, Rastinejad F
Nature 2008 Oct 29 350-356 [abstract on PubMed] [related articles] [full text]
Selected by | Paul Webb
Evaluated 26 Nov 2008

Recommended
F1000 Factor 3.0

New Finding
Tech Advance
Straightforward and reversible photoregulation of hybridization by using a photochromic nucleoside.
Ogasawara S, Maeda M
Angew Chem Int Ed Engl 2008 47(46):8839-42 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Andreas Marx
Evaluated 25 Nov 2008

Recommended
F1000 Factor 3.2

Hypothesis
New Finding
MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation.
Tay Y, Zhang J, …, Lim B, Rigoutsos I
Nature 2008 Oct 23 455(7216):1124-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Yi Eve Sun with Weihong Ge / Peter Sarnow with Cara Pager
First evaluation 25 Nov 2008 | Latest evaluation 27 Nov 2008

Must Read
F1000 Factor 6.0

Tech Advance
Molecular basis of xeroderma pigmentosum group C DNA recognition by engineered meganucleases.
Redondo P, Prieto J, …, Blanco FJ, Montoya G
Nature 2008 Nov 6 456(7218):107-11 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ulf Pettersson
Evaluated 21 Nov 2008


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