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Recommended
F1000 Factor 3.0

New Finding
 T-bet expression by dendritic cells is required for the repolarization of allergic airway inflammation.
Heckman KL, Radhakrishnan S, …, Kita H, Pease LR
Eur J Immunol 2008 Sep 38(9):2464-74 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Santa Jeremy Ono
Evaluated 6 Oct 2008

Recommended
F1000 Factor 3.0

Confirmation
New Finding
 WU and KI polyomavirus present in the respiratory tract of children, but not in immunocompetent adults.
Ren L, Gonzalez R, …, Shen K, Wang J
J Clin Virol 2008 Sep 12 [abstract on PubMed] [related articles] [full text]
Selected by | Charles Chiu
Evaluated 1 Oct 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
 Kras regulatory elements and exon 4A determine mutation specificity in lung cancer.
To MD, Wong CE, …, Di Lauro R, Balmain A
Nat Genet 2008 Oct 40(10):1240-4 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Valeri Vasioukhin
Evaluated 30 Sep 2008

Recommended
F1000 Factor 3.0

New Finding
Tech Advance
 Disruption of the CFTR gene produces a model of cystic fibrosis in newborn pigs.
Rogers CS, Stoltz DA, …, Prather RS, Welsh MJ
Science 2008 Sep 26 321(5897):1837-41 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | William H. Colledge
Evaluated 30 Sep 2008

Recommended
F1000 Factor 3.0

New Finding
 Airway epithelial versus immune cell Stat1 function for innate defense against respiratory viral infection.
Shornick LP, Wells AG, …, Agapov E, Holtzman MJ
J Immunol 2008 Mar 1 180(5):3319-28 [abstract on PubMed] [related articles] [order article]
Selected by | Charles Czuprynski
Evaluated 29 Sep 2008

Recommended
F1000 Factor 3.0

New Finding
 Cigarette smoke selectively enhances viral PAMP- and virus-induced pulmonary innate immune and remodeling responses in mice.
Kang MJ, Lee CG, …, Enelow R, Elias JA
J Clin Invest 2008 Aug 118(8):2771-84 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Thomas Robertson
Evaluated 24 Sep 2008


Recommended
F1000 Factor 3.0

Confirmation
Novel Drug Target
 Effectiveness of PTC124 treatment of cystic fibrosis caused by nonsense mutations: a prospective phase II trial.
Kerem E, Hirawat S, …, Kerem B, Wilschanski M
Lancet 2008 Aug 30 372(9640):719-27 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Charles Coutelle
Evaluated 19 Sep 2008


Recommended
F1000 Factor 3.0

Confirmation
Hypothesis
 INCREASED AIRWAY CLOSURE IS A DETERMINANT OF AIRWAY HYPERRESPONSIVENESS.
Chapman DG, Berend N, King GG, Salome CM
Eur Respir J 2008 Jul 24 [abstract on PubMed] [related articles] [full text]
Selected by | Jason H.T. Bates
Evaluated 18 Sep 2008

Recommended
F1000 Factor 3.0

New Finding
Novel Drug Target
 A critical function for CD200 in lung immune homeostasis and the severity of influenza infection.
Snelgrove RJ, Goulding J, …, Barclay AN, Hussell T
Nat Immunol 2008 Sep 9(9):1074-83 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Woodland
Evaluated 12 Sep 2008

Recommended
F1000 Factor 3.0

New Finding
Tech Advance
 The cell and molecular basis of mechanical, cold, and inflammatory pain.
Abrahamsen B, Zhao J, …, Dickenson AH, Wood JN
Science 2008 Aug 1 321(5889):702-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Michael Andresen
Evaluated 5 Sep 2008



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