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Must Read
F1000 Factor 6.0

New Finding
Angiotensin II activates the Smad pathway during epithelial mesenchymal transdifferentiation.
Carvajal G, Rodríguez-Vita J, …, Mezzano SA, Ruiz-Ortega M
Kidney Int 2008 Sep 74(5):585-95 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Norma A. Bobadilla
Evaluated 5 Sep 2008

Must Read
F1000 Factor 6.0

New Finding
TRPP2 and TRPV4 form a polymodal sensory channel complex.
Köttgen M, Buchholz B, …, Kuehn EW, Walz G
J Cell Biol 2008 Aug 11 182(3):437-47 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jens Leipziger with Helle A. Praetorius
Evaluated 4 Sep 2008

Must Read
F1000 Factor 6.0

New Finding
Novel Drug Target
Overexpression of fibroblast growth factor 23 suppresses osteoblast differentiation and matrix mineralization in vitro.
Wang H, Yoshiko Y, …, Aubin JE, Maeda N
J Bone Miner Res 2008 Jun 23(6):939-48 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Eleanor Lederer
Evaluated 3 Sep 2008

Must Read
F1000 Factor 6.0

New Finding
Refutation
Do mammals make all their own inositol hexakisphosphate?
Letcher AJ, Schell MJ, Irvine RF
Biochem J 2008 Aug 6 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Steve Shears
Evaluated 2 Sep 2008

Recommended
F1000 Factor 3.0

New Finding
Novel Drug Target
Effects of intrathecal injection of a hyperpolarization-activated channel (I(h)) inhibitor ZD7288 on bladder function in urethane-anesthetized rats.
Masuda N, Masuda H, …, de Groat WC, Yoshimura N
Neurourol Urodyn 2008 Jul 18 [abstract on PubMed] [related articles] [full text]
Selected by | Rodolfo Testa
Evaluated 1 Sep 2008

Recommended
F1000 Factor 3.0

New Finding
Klotho is a target gene of PPAR-gamma.
Zhang H, Li Y, …, Chien S, Wang N
Kidney Int 2008 Jun 11 [abstract on PubMed] [related articles] [full text]
Selected by | Carolyn Ecelbarger
Evaluated 27 Aug 2008

Recommended
F1000 Factor 3.0

New Finding
Tech Advance
Integrated pathway analysis of rat urine metabolic profiles and kidney transcriptomic profiles to elucidate the systems toxicology of model nephrotoxicants.
Xu EY, Perlina A, …, Aslamkhan AG, Xu Q
Chem Res Toxicol 2008 Aug 21(8):1548-61 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Bruce Car
Evaluated 27 Aug 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
Dominant and Redundant Functions of TFIID Involved in the Regulation of Hepatic Genes
Tatarakis A, Margaritis T, …, Tora L, Talianidis I
Molecular Cell 2008 31:531-543 [full text]
Selected by | Tony Weil
Evaluated 26 Aug 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
Murine TNF(DeltaARE) Crohn's disease model displays diminished expression of intestinal Ca2+ transporters.
Huybers S, Apostolaki M, …, Bindels RJ, Hoenderop JG
Inflamm Bowel Dis 2008 Jun 14(6):803-11 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Indu Ambudkar
Evaluated 20 Aug 2008

Recommended
F1000 Factor 3.0

New Finding
Succinate receptor GPR91 provides a direct link between high glucose levels and renin release in murine and rabbit kidney.
Toma I, Kang JJ, …, Meer E, Peti-Peterdi J
J Clin Invest 2008 Jul 118(7):2526-34 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Matthew Breyer
Evaluated 20 Aug 2008


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