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Recommended
F1000 Factor 3.0

Hypothesis
New Finding
 Association of methylenetetrahydrofolate reductase gene polymorphisms and sex-specific survival in patients with metastatic colon cancer.
Zhang W, Press OA, …, Lurje G, Lenz HJ
J Clin Oncol 2007 Aug 20 25(24):3726-31 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Eileen Dolan
Evaluated 29 Aug 2008

Exceptional
F1000 Factor 9.0

Hypothesis
New Finding
Novel Drug Target
 UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals.
Andrews ZB, Liu ZW, …, Horvath TL, Diano S
Nature 2008 Aug 14 454(7206):846-51 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Aniko Naray-Fejes-Toth
Evaluated 26 Aug 2008

Recommended
F1000 Factor 3.0

New Finding
Controversial
 Direct activation of cytosolic Ca2+ signaling and enzyme secretion by cholecystokinin in human pancreatic acinar cells.
Murphy JA, Criddle DN, …, Petersen OH, Sutton R
Gastroenterology 2008 Aug 135(2):632-41 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Silvana Curci with Matilde Colella
Evaluated 26 Aug 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
 Murine TNF(DeltaARE) Crohn's disease model displays diminished expression of intestinal Ca2+ transporters.
Huybers S, Apostolaki M, …, Bindels RJ, Hoenderop JG
Inflamm Bowel Dis 2008 Jun 14(6):803-11 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Indu Ambudkar
Evaluated 20 Aug 2008

Recommended
F1000 Factor 3.0

New Finding
Refutation
 Effects of dietary polyunsaturated fatty acids on mitochondrial metabolism in mammalian hibernation.
Gerson AR, Brown JC, …, Bernards MA, Staples JF
J Exp Biol 2008 Aug 211(Pt 16):2689-99 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Hannah Carey
Evaluated 20 Aug 2008

Recommended
F1000 Factor 3.0

New Finding
 The crop bacterial community of the hoatzin, a neotropical folivorous flying bird.
Godoy-Vitorino F, Ley RE, …, Gordon JI, Domínguez-Bello MG
Appl Environ Microbiol 2008 Aug 8 [abstract on PubMed] [related articles] [full text]
Selected by | Hannah Carey
Evaluated 20 Aug 2008

Recommended
F1000 Factor 3.0

New Finding
 Glucuronide-sulfate diconjugate as a novel metabolite of glycyrrhetic acid in rat bile.
Jing J, Ren W, …, Wang J, Jing N
Drug Metab Pharmacokinet 2008 23(3):175-80 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Gary Rankin
Evaluated 19 Aug 2008

Recommended
F1000 Factor 3.0

New Finding
 Human and chimpanzee gene expression differences replicated in mice fed different diets.
Somel M, Creely H, …, Khaitovich P, Pääbo S
PLoS ONE 2008 3(1):e1504 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Seth J Davis
Evaluated 15 Aug 2008

Must Read
F1000 Factor 6.0

New Finding
 Niemann-pick C1-like 1 mediates alpha-tocopherol transport.
Narushima K, Takada T, Yamanashi Y, Suzuki H
Mol Pharmacol 2008 Jul 74(1):42-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Kishor M Wasan with Sheila J. Thornton
Evaluated 14 Aug 2008

Recommended
F1000 Factor 3.0

New Finding
Novel Drug Target
 VAMP8 is the v-SNARE that mediates basolateral exocytosis in a mouse model of alcoholic pancreatitis.
Cosen-Binker LI, Binker MG, …, Hong W, Gaisano HY
J Clin Invest 2008 Jul 118(7):2535-51 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jens Rettig
Evaluated 13 Aug 2008


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