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Recommended
F1000 Factor 3.0

Confirmation
New Finding
 Trend in incidence of osteoporosis-related fractures among 40- to 69-year-old women: analysis of a large insurance claims database, 2000-2005.
Islam S, Liu Q, Chines A, Helzner E
Menopause 2008 Jul 25 [abstract on PubMed] [related articles] [full text]
Selected by | Henry Burger
Evaluated 21 Aug 2008

Must Read
F1000 Factor 6.0

Tech Advance
 Strategies and methods for research on sex differences in brain and behavior.
Becker JB, Arnold AP, …, Taylor J, Young E
Endocrinology 2005 Apr 146(4):1650-73 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Linda Rinaman
Evaluated 20 Aug 2008

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
 Splicing of a novel androgen receptor exon generates a constitutively active androgen receptor that mediates prostate cancer therapy resistance.
Dehm SM, Schmidt LJ, …, Vessella RL, Tindall DJ
Cancer Res 2008 Jul 1 68(13):5469-77 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Michael Weber
Evaluated 20 Aug 2008

Recommended
F1000 Factor 3.0

New Finding
 Succinate receptor GPR91 provides a direct link between high glucose levels and renin release in murine and rabbit kidney.
Toma I, Kang JJ, …, Meer E, Peti-Peterdi J
J Clin Invest 2008 Jul 118(7):2526-34 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Matthew Breyer
Evaluated 20 Aug 2008

Must Read
F1000 Factor 6.0

Hypothesis
 Abnormal glucose homeostasis in skeletal muscle-specific PGC-1alpha knockout mice reveals skeletal muscle-pancreatic beta cell crosstalk.
Handschin C, Choi CS, …, Shulman GI, Spiegelman BM
J Clin Invest 2007 Nov 117(11):3463-74 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Amira Klip with Jonathan D. Schertzer
Evaluated 20 Aug 2008

Must Read
F1000 Factor 6.0

Tech Advance
Novel Drug Target
 Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates.
Frank-Kamenetsky M, Grefhorst A, …, Horton JD, Fitzgerald K
Proc Natl Acad Sci U S A 2008 Aug 11 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Samuel Gunderson
Evaluated 19 Aug 2008

Exceptional
F1000 Factor 9.0

New Finding
 Alterations in RFamide-Related Peptide Expression Are Coordinated with the Preovulatory Luteinizing Hormone Surge.
Gibson EM, Humber SA, …, Tsutsui K, Kriegsfeld LJ
Endocrinology 2008 Jun 19 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Michael Menaker with Michael Sellix
Evaluated 19 Aug 2008

Recommended
F1000 Factor 3.0

Confirmation
New Finding
 Vasoactive Intestinal Peptide Is Critical for Circadian Regulation of Glucocorticoids.
Loh DH, Abad C, Colwell CS, Waschek JA
Neuroendocrinology 2008 Jun 19 [abstract on PubMed] [related articles] [full text]
Selected by | Michael Menaker with Jennifer A. Mohawk
Evaluated 19 Aug 2008

Must Read
F1000 Factor 6.0

New Finding
Tech Advance
 miRNAs: effectors of environmental influences on gene expression and disease.
Hudder A, Novak RF
Toxicol Sci 2008 Jun 103(2):228-40 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Bruce Car
Evaluated 19 Aug 2008

Recommended
F1000 Factor 3.0

New Finding
 Human and chimpanzee gene expression differences replicated in mice fed different diets.
Somel M, Creely H, …, Khaitovich P, Pääbo S
PLoS ONE 2008 3(1):e1504 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Seth J Davis
Evaluated 15 Aug 2008


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