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Recommended
F1000 Factor 3.0

Hypothesis
Controversial
Novel Drug Target
 Specificity in cancer immunotherapy.
Schietinger A, Philip M, Schreiber H
Semin Immunol 2008 Aug 4 [abstract on PubMed] [related articles] [full text]
Selected by | David Kranz
Evaluated 4 Sep 2008

Must Read
F1000 Factor 6.0

Hypothesis
 Traction forces mediated by alpha6beta4 integrin: implications for basement membrane organization and tumor invasion.
Rabinovitz I, Gipson IK, Mercurio AM
Mol Biol Cell 2001 Dec 12(12):4030-43 [abstract on PubMed] [related articles] [FREE full text]
Selected by | David Sherwood
Evaluated 4 Sep 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
 Catalytic organometallic anticancer complexes.
Dougan SJ, Habtemariam A, …, Parsons S, Sadler PJ
Proc Natl Acad Sci U S A 2008 Aug 19 105(33):11628-33 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Amy Barrios with Divya Krishnamurthy
Evaluated 4 Sep 2008

Recommended
F1000 Factor 3.0

Confirmation
Hypothesis
 Genomic stability and tumour suppression by the APC/C cofactor Cdh1.
García-Higuera I, Manchado E, …, Moreno S, Malumbres M
Nat Cell Biol 2008 Jul 10(7):802-11 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Maria Blasco
Evaluated 3 Sep 2008

Recommended
F1000 Factor 3.0

Confirmation
New Finding
 Regulation of epithelial branching morphogenesis and cancer cell growth of the prostate by Wnt signaling.
Wang BE, Wang XD, …, Polakis P, Gao WQ
PLoS ONE 2008 3(5):e2186 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Arthur Mercurio
Evaluated 3 Sep 2008

Exceptional
F1000 Factor 9.0

Confirmation
Tech Advance
Novel Drug Target
 Tumor regression in cancer patients by very low doses of a T cell-engaging antibody.
Bargou R, Leo E, …, Baeuerle PA, Kufer P
Science 2008 Aug 15 321(5891):974-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Etienne Joly
Evaluated 3 Sep 2008


Recommended
F1000 Factor 3.0

New Finding
 Mononuclear Myeloid-Derived "Suppressor" Cells express RAE-1 and activate NK cells.
Nausch N, Galani IE, Schlecker E, Cerwenka A
Blood 2008 Aug 27 [abstract on PubMed] [related articles] [full text]
Selected by | Mark Smyth
Evaluated 3 Sep 2008

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
 Regulation of estrogen rapid signaling through arginine methylation by PRMT1.
Le Romancer M, Treilleux I, …, Gobert-Gosse S, Corbo L
Mol Cell 2008 Jul 25 31(2):212-21 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ross Weatherman
Evaluated 3 Sep 2008

Recommended
F1000 Factor 3.0

Tech Advance
 Redesigned tetrads with altered hydrogen bonding patterns enable programming of quadruplex topologies.
Benz A, Hartig JS
Chem Commun (Camb) 2008 Sep 14 (34):4010-4012 [abstract on PubMed] [related articles] [full text]
Selected by | Scott K. Silverman
Evaluated 2 Sep 2008

Must Read
F1000 Factor 6.0

New Finding
Refutation
 Do mammals make all their own inositol hexakisphosphate?
Letcher AJ, Schell MJ, Irvine RF
Biochem J 2008 Aug 6 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Steve Shears
Evaluated 2 Sep 2008


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