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F1000 Factor 3.0

New Finding
JunB protects against myeloid malignancies by limiting hematopoietic stem cell proliferation and differentiation without affecting self-renewal.
Santaguida M, Schepers K, …, Braun BS, Passegué E
Cancer Cell 2009 Apr 7 15(4):341-52 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | R. Katherine Hyde and Paul Liu
Evaluated 3 Jul 2009

Recommended
F1000 Factor 3.0

Hypothesis
Regulation, necessity, and the misinterpretation of knockouts.
Davies J
Bioessays 2009 Jun 24 [abstract on PubMed] [related articles] [full text]
Selected by | Sheila McCormick
Evaluated 3 Jul 2009

Recommended
F1000 Factor 3.0

Tech Advance
Novel Drug Target
Structurally simple inhibitors of lanosterol 14alpha-demethylase are efficacious in a rodent model of acute chagas disease.
Suryadevara PK, Olepu S, …, Buckner FS, Gelb MH
J Med Chem 2009 Jun 25 52(12):3703-15 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Thomas W von Geldern
Evaluated 3 Jul 2009

Must Read
F1000 Factor 6.0

New Finding
Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity.
Brydges SD, Mueller JL, …, Kastner DL, Hoffman HM
Immunity 2009 Jun 19 30(6):875-87 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jenny Ting
Evaluated 3 Jul 2009

Must Read
F1000 Factor 6.0

New Finding
A mutation in the Nlrp3 gene causing inflammasome hyperactivation potentiates Th17 cell-dominant immune responses.
Meng G, Zhang F, …, Kitani A, Strober W
Immunity 2009 Jun 19 30(6):860-74 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jenny Ting
Evaluated 3 Jul 2009

Recommended
F1000 Factor 3.0

Hypothesis
The "metallo-specific" response of proteins: a perspective based on the Escherichia coli transcriptional regulator NikR.
Wang SC, Dias AV, Zamble DB
Dalton Trans 2009 Apr 14 (14):2459-66 [abstract on PubMed] [related articles] [full text]
Selected by | Crisjoe Joseph and Michael Maroney
Evaluated 3 Jul 2009

Recommended
F1000 Factor 3.0

New Finding
Novel Drug Target
The melanin-concentrating hormone system modulates cocaine reward.
Chung S, Hopf FW, …, Bonci A, Civelli O
Proc Natl Acad Sci U S A 2009 Apr 21 106(16):6772-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Audrey Seasholtz
Evaluated 3 Jul 2009

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
Serum fatty acid binding protein 4, free fatty acids, and metabolic risk markers.
Karakas SE, Almario RU, Kim K
Metabolism 2009 Jul 58(7):1002-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Gerald Shipps
Evaluated 3 Jul 2009

Recommended
F1000 Factor 3.0

New Finding
Hematopoietic stem cell development is dependent on blood flow.
North TE, Goessling W, …, Dzierzak E, Zon LI
Cell 2009 May 15 137(4):736-48 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | R. Katherine Hyde and Paul Liu
Evaluated 2 Jul 2009

Recommended
F1000 Factor 3.0

New Finding
Spontaneous phosphoinositide 3-kinase signaling dynamics drive spreading and random migration of fibroblasts.
Weiger MC, Wang CC, …, Rhoden JJ, Haugh JM
J Cell Sci 2009 Feb 1 122(Pt 3):313-23 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Christopher Janetopoulos
Evaluated 2 Jul 2009


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