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Recommended
F1000 Factor 3.0

New Finding
 Lowering of 5-nitroimidazole's mutagenicity: Towards optimal antiparasitic pharmacophore.
Crozet MD, Botta C, …, De Méo M, Vanelle P
Eur J Med Chem 2008 May 27 [abstract on PubMed] [related articles] [full text]
Selected by | Jacqueline Upcroft
Evaluated 28 Aug 2008

Must Read
F1000 Factor 6.0

Confirmation
 Imatinib pharmacokinetics and its correlation with response and safety in chronic-phase chronic myeloid leukemia: a subanalysis of the IRIS study.
Larson RA, Druker BJ, …, Wang Y, IRIS (International Randomized Interferon vs STI571) Study Group
Blood 2008 Apr 15 111(8):4022-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Susan Bates
Evaluated 28 Aug 2008

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F1000 Factor 3.0

Hypothesis
New Finding
 Trough imatinib plasma levels are associated with both cytogenetic and molecular responses to standard-dose imatinib in chronic myeloid leukemia.
Picard S, Titier K, …, Molimard M, Mahon FX
Blood 2007 Apr 15 109(8):3496-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Susan Bates
Evaluated 28 Aug 2008


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F1000 Factor 6.0

New Finding
 Complement-dependent tumor cell lysis triggered by combinations of epidermal growth factor receptor antibodies.
Dechant M, Weisner W, …, van de Winkel JG, Valerius T
Cancer Res 2008 Jul 1 68(13):4998-5003 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | John Atkinson
Evaluated 28 Aug 2008

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F1000 Factor 3.0

New Finding
Tech Advance
 A biochemical rationale for the anticancer effects of Hsp90 inhibitors: slow, tight binding inhibition by geldanamycin and its analogues.
Gooljarsingh LT, Fernandes C, …, Copeland RA, Tummino PJ
Proc Natl Acad Sci U S A 2006 May 16 103(20):7625-30 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Barrie Wilkinson
Evaluated 28 Aug 2008

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F1000 Factor 6.0

New Finding
 Protein unfolding, and the "tuning in" of reversible intermediate states, in protic ionic liquid media.
Byrne N, Angell CA
J Mol Biol 2008 May 2 378(3):707-14 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Kunihiro Kuwajima
Evaluated 28 Aug 2008

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F1000 Factor 3.0

Tech Advance
 Peptide mass fingerprinting using isotopically encoded photo-crosslinking amino acids.
Wilkins BJ, Daggett KA, Cropp TA
Mol Biosyst 2008 Sep 4(9):934-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Scott K. Silverman
Evaluated 28 Aug 2008

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F1000 Factor 3.0

Confirmation
New Finding
Tech Advance
Novel Drug Target
 Depletion of 26S proteasomes in mouse brain neurons causes neurodegeneration and Lewy-like inclusions resembling human pale bodies.
Bedford L, Hay D, …, Lowe J, Mayer RJ
J Neurosci 2008 Aug 13 28(33):8189-98 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Valina Dawson
Evaluated 28 Aug 2008

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F1000 Factor 6.0

New Finding
 Impaired cognitive flexibility and motor inhibition in unaffected first-degree relatives of patients with obsessive-compulsive disorder.
Chamberlain SR, Fineberg NA, …, Robbins TW, Sahakian BJ
Am J Psychiatry 2007 Feb 164(2):335-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Mary Phillips with Dalila Akkal
Evaluated 28 Aug 2008

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F1000 Factor 6.0

New Finding
Novel Drug Target
 p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling.
Budanov AV, Karin M
Cell 2008 Aug 8 134(3):451-60 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Kevin Sweder
Evaluated 28 Aug 2008


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