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Recommended
F1000 Factor
3.0
New Finding
JunB protects against myeloid malignancies by limiting hematopoietic stem cell proliferation and differentiation without affecting self-renewal.
Santaguida M, Schepers K, …, Braun BS, Passegué E
Cancer Cell
2009 Apr 7
15
(4):341-52 [
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Selected by
| R. Katherine Hyde and Paul Liu
Evaluated 3 Jul 2009
Recommended
F1000 Factor
3.0
Hypothesis
Regulation, necessity, and the misinterpretation of knockouts.
Davies J
Bioessays
2009 Jun 24 [
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Selected by
| Sheila McCormick
Evaluated 3 Jul 2009
Recommended
F1000 Factor
3.0
Tech Advance
Novel Drug Target
Structurally simple inhibitors of lanosterol 14alpha-demethylase are efficacious in a rodent model of acute chagas disease.
Suryadevara PK, Olepu S, …, Buckner FS, Gelb MH
J Med Chem
2009 Jun 25
52
(12):3703-15 [
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Selected by
| Thomas W von Geldern
Evaluated 3 Jul 2009
Must Read
F1000 Factor
6.0
New Finding
Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity.
Brydges SD, Mueller JL, …, Kastner DL, Hoffman HM
Immunity
2009 Jun 19
30
(6):875-87 [
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Selected by
| Jenny Ting
Evaluated 3 Jul 2009
Must Read
F1000 Factor
6.0
New Finding
A mutation in the Nlrp3 gene causing inflammasome hyperactivation potentiates Th17 cell-dominant immune responses.
Meng G, Zhang F, …, Kitani A, Strober W
Immunity
2009 Jun 19
30
(6):860-74 [
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Selected by
| Jenny Ting
Evaluated 3 Jul 2009
Recommended
F1000 Factor
3.0
Hypothesis
The "metallo-specific" response of proteins: a perspective based on the Escherichia coli transcriptional regulator NikR.
Wang SC, Dias AV, Zamble DB
Dalton Trans
2009 Apr 14
(14):2459-66 [
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Selected by
| Crisjoe Joseph and Michael Maroney
Evaluated 3 Jul 2009
Recommended
F1000 Factor
3.0
New Finding
Novel Drug Target
The melanin-concentrating hormone system modulates cocaine reward.
Chung S, Hopf FW, …, Bonci A, Civelli O
Proc Natl Acad Sci U S A
2009 Apr 21
106
(16):6772-7 [
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Selected by
| Audrey Seasholtz
Evaluated 3 Jul 2009
Recommended
F1000 Factor
3.0
Hypothesis
New Finding
Serum fatty acid binding protein 4, free fatty acids, and metabolic risk markers.
Karakas SE, Almario RU, Kim K
Metabolism
2009 Jul
58
(7):1002-7 [
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Selected by
| Gerald Shipps
Evaluated 3 Jul 2009
Recommended
F1000 Factor
3.0
New Finding
Hematopoietic stem cell development is dependent on blood flow.
North TE, Goessling W, …, Dzierzak E, Zon LI
Cell
2009 May 15
137
(4):736-48 [
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Selected by
| R. Katherine Hyde and Paul Liu
Evaluated 2 Jul 2009
Recommended
F1000 Factor
3.0
New Finding
Spontaneous phosphoinositide 3-kinase signaling dynamics drive spreading and random migration of fibroblasts.
Weiger MC, Wang CC, …, Rhoden JJ, Haugh JM
J Cell Sci
2009 Feb 1
122
(Pt 3):313-23 [
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Selected by
| Christopher Janetopoulos
Evaluated 2 Jul 2009
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