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Must Read
F1000 Factor 6.0

New Finding
 CTLA-4 blockade increases IFNgamma-producing CD4+ICOShi cells to shift the ratio of effector to regulatory T cells in cancer patients.
Liakou CI, Kamat A, …, Logothetis C, Sharma P
Proc Natl Acad Sci U S A 2008 Sep 30 105(39):14987-92 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Glenn Dranoff
Evaluated 10 Oct 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
 The protonmotive force is required for maintaining ATP homeostasis and viability of hypoxic, nonreplicating Mycobacterium tuberculosis.
Rao SP, Alonso S, …, Dick T, Pethe K
Proc Natl Acad Sci U S A 2008 Aug 19 105(33):11945-50 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Kim Lewis with Lawrence R. Mulcahy
Evaluated 10 Oct 2008

Recommended
F1000 Factor 3.0

New Finding
Novel Drug Target
 The Death Receptor 3-TNF-like protein 1A pathway drives adverse bone pathology in inflammatory arthritis.
Bull MJ, Williams AS, …, Al-Shamkhani A, Wang EC
J Exp Med 2008 Sep 29 [abstract on PubMed] [related articles] [full text]
Selected by | Richard L. Stevens
Evaluated 10 Oct 2008

Recommended
F1000 Factor 3.0

New Finding
 Suppression of renin-angiotensin gene expression in the kidney by paricalcitol.
Freundlich M, Quiroz Y, …, Li YC, Rodriguez-Iturbe B
Kidney Int 2008 Aug 27 [abstract on PubMed] [related articles] [full text]
Selected by | William Welch
Evaluated 10 Oct 2008

Must Read
F1000 Factor 6.0

Confirmation
New Finding
 Wheezing rhinovirus illnesses in early life predict asthma development in high-risk children.
Jackson DJ, Gangnon RE, …, Gern JE, Lemanske RF
Am J Respir Crit Care Med 2008 Oct 1 178(7):667-72 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Judith Black with Janette Burgess and Brian Oliver
Evaluated 10 Oct 2008

Exceptional
F1000 Factor 9.0

Confirmation
 Caspase-3 Is Enriched in Postsynaptic Densities and Increased in Alzheimer's Disease.
Louneva N, Cohen JW, …, Trojanowski JQ, Arnold SE
Am J Pathol 2008 Sep 25 [abstract on PubMed] [related articles] [full text]
Selected by | Rudolph Tanzi
Evaluated 10 Oct 2008

Must Read
F1000 Factor 6.0

New Finding
Tech Advance
 The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel.
Dong XP, Cheng X, …, Kurz T, Xu H
Nature 2008 Sep 14 [abstract on PubMed] [related articles] [full text]
Selected by | Sharona Gordon
Evaluated 9 Oct 2008

Must Read
F1000 Factor 6.0

New Finding
Refutation
 Cutting Edge: Th1 cells facilitate the entry of Th17 cells to the central nervous system during experimental autoimmune encephalomyelitis.
O'Connor RA, Prendergast CT, …, Wraith DC, Anderton SM
J Immunol 2008 Sep 15 181(6):3750-4 [abstract on PubMed] [related articles] [order article]
Selected by | Thomas Hunig
Evaluated 9 Oct 2008

Must Read
F1000 Factor 6.0

Hypothesis
 Beyond transcription factors: the role of chromatin modifying enzymes in regulating transcription required for memory.
Barrett RM, Wood MA
Learn Mem 2008 15(7):460-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Peter Rapp
Evaluated 9 Oct 2008

Recommended
F1000 Factor 3.0

Confirmation
Tech Advance
 Quantification of ligand-regulated nuclear receptor corepressor and coactivator binding, key interactions determining ligand potency and efficacy for the thyroid hormone receptor.
Jeyakumar M, Webb P, …, Scanlan TS, Katzenellenbogen JA
Biochemistry 2008 Jul 15 47(28):7465-76 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Donald Doyle
Evaluated 9 Oct 2008


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