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F1000 Factor 3.0

New Finding
 JunB protects against myeloid malignancies by limiting hematopoietic stem cell proliferation and differentiation without affecting self-renewal.
Santaguida M, Schepers K, …, Braun BS, Passegué E
Cancer Cell 2009 Apr 7 15(4):341-52 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | R. Katherine Hyde and Paul Liu
Evaluated 3 Jul 2009

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F1000 Factor 3.0

Hypothesis
 Regulation, necessity, and the misinterpretation of knockouts.
Davies J
Bioessays 2009 Jun 24 [abstract on PubMed] [related articles] [full text]
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Evaluated 3 Jul 2009

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F1000 Factor 3.0

Confirmation
New Finding
 Peptide immunotherapy in allergic asthma generates IL-10-dependent immunological tolerance associated with linked epitope suppression.
Campbell JD, Buckland KF, …, Lloyd CM, Larché M
J Exp Med 2009 Jun 15 [abstract on PubMed] [related articles] [full text]
Selected by | Georgia Fousteri, Damien Bresson and Matthias von Herrath
Evaluated 3 Jul 2009

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F1000 Factor 6.0

New Finding
 Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity.
Brydges SD, Mueller JL, …, Kastner DL, Hoffman HM
Immunity 2009 Jun 19 30(6):875-87 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jenny Ting
Evaluated 3 Jul 2009

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F1000 Factor 6.0

New Finding
 A mutation in the Nlrp3 gene causing inflammasome hyperactivation potentiates Th17 cell-dominant immune responses.
Meng G, Zhang F, …, Kitani A, Strober W
Immunity 2009 Jun 19 30(6):860-74 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jenny Ting
Evaluated 3 Jul 2009

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F1000 Factor 3.0

Tech Advance
 Development of an automated blood sampling system for use in humans.
Henley DE, Leendertz JA, …, Woltersdorf WW, Lightman SL
J Med Eng Technol 2009 33(3):199-208 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Jessop
Evaluated 3 Jul 2009

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F1000 Factor 3.0

New Finding
Novel Drug Target
 The melanin-concentrating hormone system modulates cocaine reward.
Chung S, Hopf FW, …, Bonci A, Civelli O
Proc Natl Acad Sci U S A 2009 Apr 21 106(16):6772-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Audrey Seasholtz
Evaluated 3 Jul 2009

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F1000 Factor 3.0

Hypothesis
New Finding
 Serum fatty acid binding protein 4, free fatty acids, and metabolic risk markers.
Karakas SE, Almario RU, Kim K
Metabolism 2009 Jul 58(7):1002-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Gerald Shipps
Evaluated 3 Jul 2009

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F1000 Factor 3.0

New Finding
 Hematopoietic stem cell development is dependent on blood flow.
North TE, Goessling W, …, Dzierzak E, Zon LI
Cell 2009 May 15 137(4):736-48 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | R. Katherine Hyde and Paul Liu
Evaluated 2 Jul 2009

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F1000 Factor 6.0

Confirmation
New Finding
Tech Advance
 Parvalbumin neurons and gamma rhythms enhance cortical circuit performance.
Sohal VS, Zhang F, Yizhar O, Deisseroth K
Nature 2009 Jun 4 459(7247):698-702 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Dori Derdikman and Edvard I. Moser
Evaluated 2 Jul 2009


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