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F1000 Factor 3.0

New Finding
Tech Advance
 TokenRNA: a new type of sequence-specific, label-free fluorescent biosensor for folded RNA molecules.
Afonin KA, Danilov EO, Novikova IV, Leontis NB
Chembiochem 2008 Aug 11 9(12):1902-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Sabine Müller
Evaluated 5 Sep 2008

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F1000 Factor 6.0

New Finding
 Structural basis for the cooperation of Hsp70 and Hsp110 chaperones in protein folding.
Polier S, Dragovic Z, Hartl FU, Bracher A
Cell 2008 Jun 13 133(6):1068-79 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Douglas Cyr
Evaluated 5 Sep 2008

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
 Genome-wide analysis of Fis binding in Escherichia coli indicates a causative role for A-/AT-tracts.
Cho BK, Knight EM, Barrett CL, Palsson BØ
Genome Res 2008 Jun 18(6):900-10 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Tom Tullius with Stephen C.J. Parker
Evaluated 5 Sep 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
 Origins and evolution of eukaryotic RNA interference.
Shabalina SA, Koonin EV
Trends Ecol Evol 2008 Aug 18 [abstract on PubMed] [related articles] [full text]
Selected by | Marjori Matzke
Evaluated 5 Sep 2008


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F1000 Factor 3.0

Tech Advance
 mirWIP: microRNA target prediction based on microRNA-containing ribonucleoprotein-enriched transcripts.
Hammell M, Long D, …, Ding Y, Ambros V
Nat Methods 2008 Aug 17 5 [abstract on PubMed] [related articles] [full text]
Selected by | Robert K Herman
Evaluated 5 Sep 2008

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F1000 Factor 6.0

Hypothesis
New Finding
Novel Drug Target
 CRITICAL ROLE OF ACROLEIN IN SECONDARY INJURY FOLLOWING EX VIVO SPINAL CORD TRAUMA.
Hamann K, Durkes A, …, Pond A, Shi R
J Neurochem 2008 Aug 14 [abstract on PubMed] [related articles] [full text]
Selected by | Philip Burcham
Evaluated 5 Sep 2008

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F1000 Factor 3.0

Hypothesis
New Finding
 Role of the histone H3 lysine 4 methyltransferase, SET7/9, in the regulation of NF-kappa B dependent inflammatory genes: Relevance to diabetes and inflammation.
Li Y, Reddy MA, …, Ren B, Natarajan R
J Biol Chem 2008 Jul 23 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Raghavendra Mirmira
Evaluated 4 Sep 2008

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F1000 Factor 3.0

New Finding
 The structure of CCT-Hsc70 NBD suggests a mechanism for Hsp70 delivery of substrates to the chaperonin.
Cuéllar J, Martín-Benito J, …, Carrascosa JL, Valpuesta JM
Nat Struct Mol Biol 2008 Aug 15(8):858-64 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Sophie Jackson
Evaluated 4 Sep 2008

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F1000 Factor 6.0

Hypothesis
Tech Advance
 Cyclic peptides bearing a side-chain tail: a tool to model the structure and reactivity of protein zinc sites.
Sénèque O, Bourlès E, …, Dumy P, Latour JM
Angew Chem Int Ed Engl 2008 47(36):6888-91 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Amy Barrios
Evaluated 4 Sep 2008

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F1000 Factor 6.0

Hypothesis
New Finding
 Catalytic organometallic anticancer complexes.
Dougan SJ, Habtemariam A, …, Parsons S, Sadler PJ
Proc Natl Acad Sci U S A 2008 Aug 19 105(33):11628-33 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Amy Barrios with Divya Krishnamurthy
Evaluated 4 Sep 2008


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