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F1000 Factor 3.0

Tech Advance
Novel Drug Target
 Structurally simple inhibitors of lanosterol 14alpha-demethylase are efficacious in a rodent model of acute chagas disease.
Suryadevara PK, Olepu S, …, Buckner FS, Gelb MH
J Med Chem 2009 Jun 25 52(12):3703-15 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Thomas W von Geldern
Evaluated 3 Jul 2009

Recommended
F1000 Factor 3.0

Hypothesis
 The "metallo-specific" response of proteins: a perspective based on the Escherichia coli transcriptional regulator NikR.
Wang SC, Dias AV, Zamble DB
Dalton Trans 2009 Apr 14 (14):2459-66 [abstract on PubMed] [related articles] [full text]
Selected by | Crisjoe Joseph and Michael Maroney
Evaluated 3 Jul 2009

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
 Serum fatty acid binding protein 4, free fatty acids, and metabolic risk markers.
Karakas SE, Almario RU, Kim K
Metabolism 2009 Jul 58(7):1002-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Gerald Shipps
Evaluated 3 Jul 2009

Recommended
F1000 Factor 3.0

New Finding
 Spontaneous phosphoinositide 3-kinase signaling dynamics drive spreading and random migration of fibroblasts.
Weiger MC, Wang CC, …, Rhoden JJ, Haugh JM
J Cell Sci 2009 Feb 1 122(Pt 3):313-23 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Christopher Janetopoulos
Evaluated 2 Jul 2009

Recommended
F1000 Factor 3.0

Confirmation
New Finding
 Tailoring RNA modular units on a common scaffold: a modular ribozyme with a catalytic unit for beta-nicotinamide mononucleotide-activated RNA ligation.
Fujita Y, Furuta H, Ikawa Y
RNA 2009 May 15(5):877-88 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Aaron S. Burton and Niles Lehman
Evaluated 2 Jul 2009

Must Read
F1000 Factor 6.0

Confirmation
New Finding
Tech Advance
 A dictionary for protein side-chain entropies from NMR order parameters.
Li DW, Brüschweiler R
J Am Chem Soc 2009 Jun 3 131(21):7226-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Mikael Akke
Evaluated 2 Jul 2009

Must Read
F1000 Factor 6.0

New Finding
Tech Advance
 Effects of Branching Architecture and Linker on the Activity of Hyperbranched Polymer-Drug Conjugates.
Perumal O, Khandare J, …, Lieh-Lai M, Kannan RM
Bioconjug Chem 2009 Apr 29 20 [abstract on PubMed] [related articles] [full text]
Selected by | Donald A Tomalia
Evaluated 2 Jul 2009

Recommended
F1000 Factor 3.0

New Finding
 DNA synthesis across an abasic lesion by human DNA polymerase iota.
Nair DT, Johnson RE, …, Prakash S, Aggarwal AK
Structure 2009 Apr 15 17(4):530-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Sylvie Doublie
Evaluated 1 Jul 2009

Recommended
F1000 Factor 3.0

New Finding
 Lymphoid tissue-specific homing of bone marrow-derived dendritic cells.
Creusot RJ, Yaghoubi SS, …, Gambhir SS, Fathman CG
Blood 2009 Jun 25 113(26):6638-47 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Serreze
Evaluated 30 Jun 2009

Recommended
F1000 Factor 3.0

Confirmation
Novel Drug Target
 Selective Pharmacological Blockade of the TRPV1 Receptor Suppresses Sensory Reflexes of the Rodent Bladder.
Cefalu JS, Guillon MA, …, Nunn PA, Cockayne DA
J Urol 2009 Jun 17 [abstract on PubMed] [related articles] [full text]
Selected by | Rodolfo Testa
Evaluated 30 Jun 2009


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