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F1000 Factor 3.0

New Finding
Tech Advance
 TokenRNA: a new type of sequence-specific, label-free fluorescent biosensor for folded RNA molecules.
Afonin KA, Danilov EO, Novikova IV, Leontis NB
Chembiochem 2008 Aug 11 9(12):1902-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Sabine Müller
Evaluated 5 Sep 2008

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
 Genome-wide analysis of Fis binding in Escherichia coli indicates a causative role for A-/AT-tracts.
Cho BK, Knight EM, Barrett CL, Palsson BØ
Genome Res 2008 Jun 18(6):900-10 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Tom Tullius with Stephen C.J. Parker
Evaluated 5 Sep 2008

Exceptional
F1000 Factor 9.0

Confirmation
 Physiochemical drug properties associated with in vivo toxicological outcomes.
Hughes JD, Blagg J, …, Whiteley L, Zhang Y
Bioorg Med Chem Lett 2008 Sep 1 18(17):4872-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Peter Grootenhuis
Evaluated 5 Sep 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
Novel Drug Target
 CRITICAL ROLE OF ACROLEIN IN SECONDARY INJURY FOLLOWING EX VIVO SPINAL CORD TRAUMA.
Hamann K, Durkes A, …, Pond A, Shi R
J Neurochem 2008 Aug 14 [abstract on PubMed] [related articles] [full text]
Selected by | Philip Burcham
Evaluated 5 Sep 2008

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F1000 Factor 3.0

Hypothesis
New Finding
 Role of the histone H3 lysine 4 methyltransferase, SET7/9, in the regulation of NF-kappa B dependent inflammatory genes: Relevance to diabetes and inflammation.
Li Y, Reddy MA, …, Ren B, Natarajan R
J Biol Chem 2008 Jul 23 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Raghavendra Mirmira
Evaluated 4 Sep 2008

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F1000 Factor 3.0

New Finding
 The structure of CCT-Hsc70 NBD suggests a mechanism for Hsp70 delivery of substrates to the chaperonin.
Cuéllar J, Martín-Benito J, …, Carrascosa JL, Valpuesta JM
Nat Struct Mol Biol 2008 Aug 15(8):858-64 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Sophie Jackson
Evaluated 4 Sep 2008

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F1000 Factor 6.0

Hypothesis
Tech Advance
 Cyclic peptides bearing a side-chain tail: a tool to model the structure and reactivity of protein zinc sites.
Sénèque O, Bourlès E, …, Dumy P, Latour JM
Angew Chem Int Ed Engl 2008 47(36):6888-91 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Amy Barrios
Evaluated 4 Sep 2008

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F1000 Factor 6.0

Hypothesis
New Finding
 Catalytic organometallic anticancer complexes.
Dougan SJ, Habtemariam A, …, Parsons S, Sadler PJ
Proc Natl Acad Sci U S A 2008 Aug 19 105(33):11628-33 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Amy Barrios with Divya Krishnamurthy
Evaluated 4 Sep 2008

Exceptional
F1000 Factor 9.0

Hypothesis
New Finding
Tech Advance
Novel Drug Target
 Bacterial peptidoglycan triggers Candida albicans hyphal growth by directly activating the adenylyl cyclase Cyr1p.
Xu XL, Lee RT, …, Zhu Y, Wang Y
Cell Host Microbe 2008 Jul 17 4(1):28-39 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joe Heitman
Evaluated 4 Sep 2008

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F1000 Factor 3.0

Confirmation
New Finding
Tech Advance
 In vivo reconstitution of autophagy in Saccharomyces cerevisiae.
Cao Y, Cheong H, Song H, Klionsky DJ
J Cell Biol 2008 Aug 25 182(4):703-13 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Vojo Deretic
Evaluated 4 Sep 2008


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