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Must Read
F1000 Factor 6.0

New Finding
Controversial
Refutation
 Intratelencephalic corticostriatal neurons equally excite striatonigral and striatopallidal neurons and their discharge activity is selectively reduced in experimental parkinsonism.
Ballion B, Mallet N, …, Lanciego JL, Gonon F
Eur J Neurosci 2008 May 27(9):2313-21 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | James Surmeier
Evaluated 5 Sep 2008

Recommended
F1000 Factor 3.0

New Finding
 Persistent Sodium Current Is a Nonsynaptic Substrate for Long-Term Associative Memory.
Nikitin ES, Vavoulis DV, …, Benjamin PR, Kemenes G
Curr Biol 2008 Aug 26 18(16):1221-1226 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Randolf Menzel
Evaluated 5 Sep 2008

Recommended
F1000 Factor 3.0

New Finding
Tech Advance
 Culturing of human peripheral blood cells reveals unsuspected lymphocyte responses relevant to HIV disease.
Sahaf B, Atkuri K, …, Herzenberg LA, Herzenberg LA
Proc Natl Acad Sci U S A 2008 Apr 1 105(13):5111-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | James Gusella
Evaluated 5 Sep 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
 Origins and evolution of eukaryotic RNA interference.
Shabalina SA, Koonin EV
Trends Ecol Evol 2008 Aug 18 [abstract on PubMed] [related articles] [full text]
Selected by | Marjori Matzke
Evaluated 5 Sep 2008


Must Read
F1000 Factor 6.0

Hypothesis
New Finding
 Syntrophin mutation associated with long QT syndrome through activation of the nNOS-SCN5A macromolecular complex.
Ueda K, Valdivia C, …, Ackerman MJ, Makielski JC
Proc Natl Acad Sci U S A 2008 Jul 8 105(27):9355-60 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Hugues Abriel
Evaluated 5 Sep 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
 Alpha-1-Syntrophin Mutation and the Long QT Syndrome: a disease of sodium channel disruption.
Wu G, Ai T, Cheng J, Vatta M
Circ Arrhythm Electrophysiol 2008 1:193-201 [full text]
Selected by | Hugues Abriel
Evaluated 5 Sep 2008

Recommended
F1000 Factor 3.0

Tech Advance
 mirWIP: microRNA target prediction based on microRNA-containing ribonucleoprotein-enriched transcripts.
Hammell M, Long D, …, Ding Y, Ambros V
Nat Methods 2008 Aug 17 5 [abstract on PubMed] [related articles] [full text]
Selected by | Robert K Herman
Evaluated 5 Sep 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
Novel Drug Target
 CRITICAL ROLE OF ACROLEIN IN SECONDARY INJURY FOLLOWING EX VIVO SPINAL CORD TRAUMA.
Hamann K, Durkes A, …, Pond A, Shi R
J Neurochem 2008 Aug 14 [abstract on PubMed] [related articles] [full text]
Selected by | Philip Burcham
Evaluated 5 Sep 2008

Recommended
F1000 Factor 3.0

Confirmation
Hypothesis
New Finding
 A common sequence motif associated with recombination hot spots and genome instability in humans.
Myers S, Freeman C, …, Donnelly P, McVean G
Nat Genet 2008 Aug 24 40 [abstract on PubMed] [related articles] [full text]
Selected by | Karin Schmitt
Evaluated 5 Sep 2008

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
Controversial
 Structural and functional evidence that Nck interaction with CD3epsilon regulates T-cell receptor activity.
Takeuchi K, Yang H, …, Reinherz EL, Wagner G
J Mol Biol 2008 Jul 18 380(4):704-16 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Michael Dustin with Kaushik Choudhuri
Evaluated 4 Sep 2008


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