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Must Read
F1000 Factor 6.0

Hypothesis
New Finding
 The protonmotive force is required for maintaining ATP homeostasis and viability of hypoxic, nonreplicating Mycobacterium tuberculosis.
Rao SP, Alonso S, …, Dick T, Pethe K
Proc Natl Acad Sci U S A 2008 Aug 19 105(33):11945-50 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Kim Lewis with Lawrence R. Mulcahy
Evaluated 10 Oct 2008

Recommended
F1000 Factor 3.0

New Finding
Novel Drug Target
 The Death Receptor 3-TNF-like protein 1A pathway drives adverse bone pathology in inflammatory arthritis.
Bull MJ, Williams AS, …, Al-Shamkhani A, Wang EC
J Exp Med 2008 Sep 29 [abstract on PubMed] [related articles] [full text]
Selected by | Richard L. Stevens
Evaluated 10 Oct 2008

Must Read
F1000 Factor 6.0

Confirmation
New Finding
 Wheezing rhinovirus illnesses in early life predict asthma development in high-risk children.
Jackson DJ, Gangnon RE, …, Gern JE, Lemanske RF
Am J Respir Crit Care Med 2008 Oct 1 178(7):667-72 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Judith Black with Janette Burgess and Brian Oliver
Evaluated 10 Oct 2008

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
Tech Advance
 Spatial organization of a replicating bacterial chromosome.
Berlatzky IA, Rouvinski A, Ben-Yehuda S
Proc Natl Acad Sci U S A 2008 Sep 16 105(37):14136-40 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Linda Amos
Evaluated 10 Oct 2008

Must Read
F1000 Factor 6.0

New Finding
Novel Drug Target
 Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice.
Hsu HC, Yang P, …, Williams RW, Mountz JD
Nat Immunol 2008 Feb 9(2):166-75 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Antony Basten with Pablo Silveira
Evaluated 10 Oct 2008


Recommended
F1000 Factor 3.0

Tech Advance
 Functionally competent eosinophils differentiated ex vivo in high purity from normal mouse bone marrow.
Dyer KD, Moser JM, …, Percopo CM, Rosenberg HF
J Immunol 2008 Sep 15 181(6):4004-9 [abstract on PubMed] [related articles] [order article]
Selected by | Achsah Keegan
Evaluated 10 Oct 2008

Recommended
F1000 Factor 3.0

New Finding
Tech Advance
 Bioencapsulation of living bacteria (Escherichia coli) with poly(silicate) after transformation with silicatein-alpha gene.
Müller WE, Engel S, …, Divekar M, Schröder HC
Biomaterials 2008 Mar 29(7):771-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Russell Hill
Evaluated 9 Oct 2008

Recommended
F1000 Factor 3.0

New Finding
 Molecular analysis of a novel gene cluster encoding an insect toxin in plant-associated strains of Pseudomonas fluorescens.
Péchy-Tarr M, Bruck DJ, …, Loper JE, Keel C
Environ Microbiol 2008 Sep 10(9):2368-86 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ben Lugtenberg
Evaluated 9 Oct 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
 Recognition of misfolded proteins by Lon, a AAA(+) protease.
Gur E, Sauer RT
Genes Dev 2008 Aug 15 22(16):2267-77 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Tracy Raivio
Evaluated 9 Oct 2008

Recommended
F1000 Factor 3.0

New Finding
 Conserved factors Ryp2 and Ryp3 control cell morphology and infectious spore formation in the fungal pathogen Histoplasma capsulatum.
Webster RH, Sil A
Proc Natl Acad Sci U S A 2008 Sep 23 105(38):14573-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Gerhard Braus
Evaluated 9 Oct 2008


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