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F1000 Factor 3.0

New Finding
 Hematopoietic stem cell development is dependent on blood flow.
North TE, Goessling W, …, Dzierzak E, Zon LI
Cell 2009 May 15 137(4):736-48 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | R. Katherine Hyde and Paul Liu
Evaluated 2 Jul 2009

Exceptional
F1000 Factor 9.0

New Finding
Tech Advance
 The establishment of gene silencing at single-cell resolution.
Osborne EA, Dudoit S, Rine J
Nat Genet 2009 Jul 41(7):800-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Fyodor Urnov
Evaluated 2 Jul 2009

Recommended
F1000 Factor 3.0

New Finding
 LysRS serves as a key signaling molecule in the immune response by regulating gene expression.
Yannay-Cohen N, Carmi-Levy I, …, Nechushtan H, Razin E
Mol Cell 2009 Jun 12 34(5):603-11 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Richard L. Stevens
Evaluated 2 Jul 2009

Must Read
F1000 Factor 6.0

New Finding
 Cytokine/Jak/Stat signaling mediates regeneration and homeostasis in the Drosophila midgut.
Jiang H, Patel PH, …, McEwen DG, Edgar BA
Cell 2009 Jun 26 137(7):1343-55 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Yukiko Yamashita
Evaluated 2 Jul 2009

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
 Twist-1 is a PPARdelta-inducible, negative-feedback regulator of PGC-1alpha in brown fat metabolism.
Pan D, Fujimoto M, Lopes A, Wang YX
Cell 2009 Apr 3 137(1):73-86 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Fredric Wondisford
Evaluated 2 Jul 2009

Recommended
F1000 Factor 3.0

New Finding
Novel Drug Target
 Resveratrol induces mitochondrial biogenesis in endothelial cells.
Csiszar A, Labinskyy N, …, Zhang C, Ungvari ZI
Am J Physiol Heart Circ Physiol 2009 May 8 297 [abstract on PubMed] [related articles] [full text]
Selected by | Julian O. M. Ormerod and Michael Frenneaux
Evaluated 2 Jul 2009

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F1000 Factor 3.0

Confirmation
New Finding
Tech Advance
 Novel persistence genes in Pseudomonas aeruginosa identified by high-throughput screening.
De Groote VN, Verstraeten N, …, Cornelis P, Michiels J
FEMS Microbiol Lett 2009 May 21 [abstract on PubMed] [related articles] [full text]
Selected by | Lawrence R. Mulcahy and Kim Lewis
Evaluated 2 Jul 2009

Must Read
F1000 Factor 6.0

Hypothesis
Tech Advance
 Hyper-recombination, diversity, and antibiotic resistance in pneumococcus.
Hanage WP, Fraser C, …, Connor TR, Corander J
Science 2009 Jun 12 324(5933):1454-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Brendan Wren
Evaluated 2 Jul 2009

Must Read
F1000 Factor 6.0

New Finding
Novel Drug Target
 Cardiac 12/15 lipoxygenase-induced inflammation is involved in heart failure.
Kayama Y, Minamino T, …, Aburatani H, Komuro I
J Exp Med 2009 Jun 22 [abstract on PubMed] [related articles] [full text]
Selected by | William A Muller
Evaluated 1 Jul 2009

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F1000 Factor 3.0

Hypothesis
New Finding
 DnaAcos hyperinitiates by circumventing regulatory pathways that control the frequency of initiation in Escherichia coli.
Felczak MM, Kaguni JM
Mol Microbiol 2009 Jun 72(6):1348-63 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martin Marinus
Evaluated 1 Jul 2009


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