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F1000 Factor 3.0

New Finding
 Transforming growth factor-beta suppresses the activation of CD8+ T-cells when naive but promotes their survival and function once antigen experienced: a two-faced impact on autoimmunity.
Filippi CM, Juedes AE, …, Flavell RA, von Herrath MG
Diabetes 2008 Oct 57(10):2684-92 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Bart Roep
Evaluated 6 Oct 2008

Must Read
F1000 Factor 6.0

Tech Advance
 Dissecting T cell lineage relationships by cellular barcoding.
Schepers K, Swart E, …, Arens R, Schumacher TN
J Exp Med 2008 Sep 29 205(10):2309-18 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Thomas Hunig
Evaluated 6 Oct 2008

Exceptional
F1000 Factor 9.0

New Finding
Novel Drug Target
 Selective nucleoside triphosphate diphosphohydrolase-2 (NTPDase2) inhibitors: nucleotide mimetics derived from uridine-5'-carboxamide.
Brunschweiger A, Iqbal J, …, Knowles AF, Müller CE
J Med Chem 2008 Aug 14 51(15):4518-28 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Geoffrey Burnstock
Evaluated 6 Oct 2008

Recommended
F1000 Factor 3.0

Hypothesis
 A mutual support mechanism through intercellular movement of CAPRICE and GLABRA3 can pattern the Arabidopsis root epidermis.
Savage NS, Walker T, …, Dolan L, Monk NA
PLoS Biol 2008 Sep 23 6(9):e235 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Elena Alvarez-Buylla with Mariana Benitez Keinrad
Evaluated 6 Oct 2008

Must Read
F1000 Factor 4.8

Hypothesis
New Finding
 GILT is a critical host factor for Listeria monocytogenes infection.
Singh R, Jamieson A, Cresswell P
Nature 2008 Sep 24 [abstract on PubMed] [related articles] [full text]
Selected by | Peter Jensen / Clifford Harding
Evaluated 6 Oct 2008

Recommended
F1000 Factor 3.0

New Finding
 Spinocerebellar ataxia type 6 knockin mice develop a progressive neuronal dysfunction with age-dependent accumulation of mutant CaV2.1 channels.
Watase K, Barrett CF, …, Tsien RW, Zoghbi HY
Proc Natl Acad Sci U S A 2008 Aug 19 105(33):11987-92 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Annette Dolphin
Evaluated 6 Oct 2008

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
Tech Advance
 A Protracted and Dynamic Maturation Schedule Underlies Arabidopsis Leaf Development.
Efroni I, Blum E, Goldshmidt A, Eshed Y
Plant Cell 2008 Sep 19 [abstract on PubMed] [related articles] [full text]
Selected by | Michael Lenhard
Evaluated 6 Oct 2008

Must Read
F1000 Factor 6.0

New Finding
Novel Drug Target
 Reduced atherosclerotic lesions in P2Y1/apolipoprotein E double-knockout mice: the contribution of non-hematopoietic-derived P2Y1 receptors.
Hechler B, Freund M, …, Cazenave JP, Gachet C
Circulation 2008 Aug 12 118(7):754-63 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Geoffrey Burnstock
Evaluated 6 Oct 2008

Recommended
F1000 Factor 3.0

New Finding
 The immunity-related GTPase Irgm1 promotes the expansion of activated CD4(+) T cell populations by preventing interferon-gamma-induced cell death.
Feng CG, Zheng L, …, Lenardo MJ, Sher A
Nat Immunol 2008 Sep 21 [abstract on PubMed] [related articles] [full text]
Selected by | George Yap
Evaluated 3 Oct 2008

Recommended
F1000 Factor 3.0

Hypothesis
Novel Drug Target
 P2 receptors in atherosclerosis and postangioplasty restenosis.
Seye CI, Kong Q, …, Erb L, Weisman GA
Purinergic Signal 2007 Mar 3(1-2):153-62 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Geoffrey Burnstock
Evaluated 3 Oct 2008


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