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Recommended
F1000 Factor 3.0

Confirmation
New Finding
Genomic surveys by methylation-sensitive SNP analysis identify sequence-dependent allele-specific DNA methylation.
Kerkel K, Spadola A, …, Haghighi F, Tycko B
Nat Genet 2008 Jul 40(7):904-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stephan Beck
Evaluated 5 Sep 2008

Recommended
F1000 Factor 3.0

New Finding
Tech Advance
TokenRNA: a new type of sequence-specific, label-free fluorescent biosensor for folded RNA molecules.
Afonin KA, Danilov EO, Novikova IV, Leontis NB
Chembiochem 2008 Aug 11 9(12):1902-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Sabine Müller
Evaluated 5 Sep 2008

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
Genome-wide analysis of Fis binding in Escherichia coli indicates a causative role for A-/AT-tracts.
Cho BK, Knight EM, Barrett CL, Palsson BØ
Genome Res 2008 Jun 18(6):900-10 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Tom Tullius with Stephen C.J. Parker
Evaluated 5 Sep 2008

Exceptional
F1000 Factor 9.0

New Finding
Tech Advance
Controversial
Resolving individuals contributing trace amounts of DNA to highly complex mixtures using high-density SNP genotyping microarrays.
Homer N, Szelinger S, …, Nelson SF, Craig DW
PLoS Genet 2008 Aug 4(8):e1000167 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Daniel Weeks
Evaluated 5 Sep 2008

Exceptional
F1000 Factor 9.0

Confirmation
Physiochemical drug properties associated with in vivo toxicological outcomes.
Hughes JD, Blagg J, …, Whiteley L, Zhang Y
Bioorg Med Chem Lett 2008 Sep 1 18(17):4872-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Peter Grootenhuis
Evaluated 5 Sep 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
Syntrophin mutation associated with long QT syndrome through activation of the nNOS-SCN5A macromolecular complex.
Ueda K, Valdivia C, …, Ackerman MJ, Makielski JC
Proc Natl Acad Sci U S A 2008 Jul 8 105(27):9355-60 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Hugues Abriel
Evaluated 5 Sep 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
Alpha-1-Syntrophin Mutation and the Long QT Syndrome: a disease of sodium channel disruption.
Wu G, Ai T, Cheng J, Vatta M
Circ Arrhythm Electrophysiol 2008 1:193-201 [full text]
Selected by | Hugues Abriel
Evaluated 5 Sep 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
Novel Drug Target
CRITICAL ROLE OF ACROLEIN IN SECONDARY INJURY FOLLOWING EX VIVO SPINAL CORD TRAUMA.
Hamann K, Durkes A, …, Pond A, Shi R
J Neurochem 2008 Aug 14 [abstract on PubMed] [related articles] [full text]
Selected by | Philip Burcham
Evaluated 5 Sep 2008

Recommended
F1000 Factor 3.0

Confirmation
Hypothesis
New Finding
A common sequence motif associated with recombination hot spots and genome instability in humans.
Myers S, Freeman C, …, Donnelly P, McVean G
Nat Genet 2008 Aug 24 40 [abstract on PubMed] [related articles] [full text]
Selected by | Karin Schmitt
Evaluated 5 Sep 2008

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
Role of the histone H3 lysine 4 methyltransferase, SET7/9, in the regulation of NF-kappa B dependent inflammatory genes: Relevance to diabetes and inflammation.
Li Y, Reddy MA, …, Ren B, Natarajan R
J Biol Chem 2008 Jul 23 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Raghavendra Mirmira
Evaluated 4 Sep 2008


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