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Recommended
F1000 Factor
3.0
Confirmation
New Finding
Genomic surveys by methylation-sensitive SNP analysis identify sequence-dependent allele-specific DNA methylation.
Kerkel K, Spadola A, …, Haghighi F, Tycko B
Nat Genet
2008 Jul
40
(7):904-8 [
abstract on PubMed
] [
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full text
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Selected by
| Stephan Beck
Evaluated 5 Sep 2008
Recommended
F1000 Factor
3.0
New Finding
Tech Advance
TokenRNA: a new type of sequence-specific, label-free fluorescent biosensor for folded RNA molecules.
Afonin KA, Danilov EO, Novikova IV, Leontis NB
Chembiochem
2008 Aug 11
9
(12):1902-5 [
abstract on PubMed
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Selected by
| Sabine Müller
Evaluated 5 Sep 2008
Recommended
F1000 Factor
3.0
Hypothesis
New Finding
Genome-wide analysis of Fis binding in Escherichia coli indicates a causative role for A-/AT-tracts.
Cho BK, Knight EM, Barrett CL, Palsson BØ
Genome Res
2008 Jun
18
(6):900-10 [
abstract on PubMed
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Selected by
| Tom Tullius with Stephen C.J. Parker
Evaluated 5 Sep 2008
Exceptional
F1000 Factor
9.0
New Finding
Tech Advance
Controversial
Resolving individuals contributing trace amounts of DNA to highly complex mixtures using high-density SNP genotyping microarrays.
Homer N, Szelinger S, …, Nelson SF, Craig DW
PLoS Genet
2008 Aug
4
(8):e1000167 [
abstract on PubMed
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FREE full text
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Selected by
| Daniel Weeks
Evaluated 5 Sep 2008
Exceptional
F1000 Factor
9.0
Confirmation
Physiochemical drug properties associated with in vivo toxicological outcomes.
Hughes JD, Blagg J, …, Whiteley L, Zhang Y
Bioorg Med Chem Lett
2008 Sep 1
18
(17):4872-5 [
abstract on PubMed
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Selected by
| Peter Grootenhuis
Evaluated 5 Sep 2008
Must Read
F1000 Factor
6.0
Hypothesis
New Finding
Syntrophin mutation associated with long QT syndrome through activation of the nNOS-SCN5A macromolecular complex.
Ueda K, Valdivia C, …, Ackerman MJ, Makielski JC
Proc Natl Acad Sci U S A
2008 Jul 8
105
(27):9355-60 [
abstract on PubMed
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FREE full text
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Selected by
| Hugues Abriel
Evaluated 5 Sep 2008
Must Read
F1000 Factor
6.0
Hypothesis
New Finding
Alpha-1-Syntrophin Mutation and the Long QT Syndrome: a disease of sodium channel disruption.
Wu G, Ai T, Cheng J, Vatta M
Circ Arrhythm Electrophysiol
2008
1
:193-201 [
full text
]
Selected by
| Hugues Abriel
Evaluated 5 Sep 2008
Must Read
F1000 Factor
6.0
Hypothesis
New Finding
Novel Drug Target
CRITICAL ROLE OF ACROLEIN IN SECONDARY INJURY FOLLOWING EX VIVO SPINAL CORD TRAUMA.
Hamann K, Durkes A, …, Pond A, Shi R
J Neurochem
2008 Aug 14 [
abstract on PubMed
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full text
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Selected by
| Philip Burcham
Evaluated 5 Sep 2008
Recommended
F1000 Factor
3.0
Confirmation
Hypothesis
New Finding
A common sequence motif associated with recombination hot spots and genome instability in humans.
Myers S, Freeman C, …, Donnelly P, McVean G
Nat Genet
2008 Aug 24
40
[
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Selected by
| Karin Schmitt
Evaluated 5 Sep 2008
Recommended
F1000 Factor
3.0
Hypothesis
New Finding
Role of the histone H3 lysine 4 methyltransferase, SET7/9, in the regulation of NF-kappa B dependent inflammatory genes: Relevance to diabetes and inflammation.
Li Y, Reddy MA, …, Ren B, Natarajan R
J Biol Chem
2008 Jul 23 [
abstract on PubMed
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FREE full text
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Selected by
| Raghavendra Mirmira
Evaluated 4 Sep 2008
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