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Must Read
F1000 Factor 6.0

Confirmation
 Imatinib pharmacokinetics and its correlation with response and safety in chronic-phase chronic myeloid leukemia: a subanalysis of the IRIS study.
Larson RA, Druker BJ, …, Wang Y, IRIS (International Randomized Interferon vs STI571) Study Group
Blood 2008 Apr 15 111(8):4022-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Susan Bates
Evaluated 28 Aug 2008

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
 Trough imatinib plasma levels are associated with both cytogenetic and molecular responses to standard-dose imatinib in chronic myeloid leukemia.
Picard S, Titier K, …, Molimard M, Mahon FX
Blood 2007 Apr 15 109(8):3496-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Susan Bates
Evaluated 28 Aug 2008


Must Read
F1000 Factor 6.0

New Finding
 Protein unfolding, and the "tuning in" of reversible intermediate states, in protic ionic liquid media.
Byrne N, Angell CA
J Mol Biol 2008 May 2 378(3):707-14 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Kunihiro Kuwajima
Evaluated 28 Aug 2008

Must Read
F1000 Factor 6.0

Hypothesis
New Finding
 The transcriptional program underlying the physiology of clostridial sporulation.
Jones SW, Paredes CJ, …, Senger RS, Papoutsakis ET
Genome Biol 2008 Jul 16 9(7):R114 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Juergen Wiegel
Evaluated 28 Aug 2008

Recommended
F1000 Factor 3.0

Tech Advance
 Peptide mass fingerprinting using isotopically encoded photo-crosslinking amino acids.
Wilkins BJ, Daggett KA, Cropp TA
Mol Biosyst 2008 Sep 4(9):934-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Scott K. Silverman
Evaluated 28 Aug 2008

Recommended
F1000 Factor 3.0

Confirmation
New Finding
Tech Advance
Novel Drug Target
 Depletion of 26S proteasomes in mouse brain neurons causes neurodegeneration and Lewy-like inclusions resembling human pale bodies.
Bedford L, Hay D, …, Lowe J, Mayer RJ
J Neurosci 2008 Aug 13 28(33):8189-98 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Valina Dawson
Evaluated 28 Aug 2008

Must Read
F1000 Factor 6.0

New Finding
 Nucleotide excision repair driven by the dissociation of CAK from TFIIH.
Coin F, Oksenych V, …, Blattner C, Egly JM
Mol Cell 2008 Jul 11 31(1):9-20 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Pengbo Zhou
Evaluated 28 Aug 2008

Must Read
F1000 Factor 6.0

New Finding
 Impaired cognitive flexibility and motor inhibition in unaffected first-degree relatives of patients with obsessive-compulsive disorder.
Chamberlain SR, Fineberg NA, …, Robbins TW, Sahakian BJ
Am J Psychiatry 2007 Feb 164(2):335-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Mary Phillips with Dalila Akkal
Evaluated 28 Aug 2008

Must Read
F1000 Factor 6.0

New Finding
Novel Drug Target
 p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling.
Budanov AV, Karin M
Cell 2008 Aug 8 134(3):451-60 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Kevin Sweder
Evaluated 28 Aug 2008

Recommended
F1000 Factor 3.0

Tech Advance
 Gating mechanisms of mechanosensitive channels of large conductance, I: a continuum mechanics-based hierarchical framework.
Chen X, Cui Q, …, Yoo J, Yethiraj A
Biophys J 2008 Jul 95(2):563-80 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Nathan Baker
Evaluated 28 Aug 2008


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