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Recommended
F1000 Factor 3.0

New Finding
 JunB protects against myeloid malignancies by limiting hematopoietic stem cell proliferation and differentiation without affecting self-renewal.
Santaguida M, Schepers K, …, Braun BS, Passegué E
Cancer Cell 2009 Apr 7 15(4):341-52 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | R. Katherine Hyde and Paul Liu
Evaluated 3 Jul 2009

Recommended
F1000 Factor 3.0

Hypothesis
 Regulation, necessity, and the misinterpretation of knockouts.
Davies J
Bioessays 2009 Jun 24 [abstract on PubMed] [related articles] [full text]
Selected by | Sheila McCormick
Evaluated 3 Jul 2009

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F1000 Factor 3.0

Confirmation
New Finding
 Peptide immunotherapy in allergic asthma generates IL-10-dependent immunological tolerance associated with linked epitope suppression.
Campbell JD, Buckland KF, …, Lloyd CM, Larché M
J Exp Med 2009 Jun 15 [abstract on PubMed] [related articles] [full text]
Selected by | Georgia Fousteri, Damien Bresson and Matthias von Herrath
Evaluated 3 Jul 2009

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F1000 Factor 3.0

Tech Advance
Novel Drug Target
 Structurally simple inhibitors of lanosterol 14alpha-demethylase are efficacious in a rodent model of acute chagas disease.
Suryadevara PK, Olepu S, …, Buckner FS, Gelb MH
J Med Chem 2009 Jun 25 52(12):3703-15 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Thomas W von Geldern
Evaluated 3 Jul 2009

Must Read
F1000 Factor 6.0

New Finding
 Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity.
Brydges SD, Mueller JL, …, Kastner DL, Hoffman HM
Immunity 2009 Jun 19 30(6):875-87 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jenny Ting
Evaluated 3 Jul 2009

Recommended
F1000 Factor 3.0

Confirmation
Hypothesis
 Controlling Eutrophication along the Freshwater-Marine Continuum: Dual Nutrient (N and P) Reductions are Essential.
Paerl HW
Estuaries and Coasts 2009 32:593-601 [full text]
Selected by | Russell Moll
Evaluated 3 Jul 2009

Must Read
F1000 Factor 6.0

New Finding
 A mutation in the Nlrp3 gene causing inflammasome hyperactivation potentiates Th17 cell-dominant immune responses.
Meng G, Zhang F, …, Kitani A, Strober W
Immunity 2009 Jun 19 30(6):860-74 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jenny Ting
Evaluated 3 Jul 2009

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F1000 Factor 3.0

New Finding
 Identification of the pollen self-incompatibility determinant in Papaver rhoeas.
Wheeler MJ, de Graaf BH, …, Franklin FC, Franklin-Tong VE
Nature 2009 Jun 18 459(7249):992-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Smyth
Evaluated 3 Jul 2009

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F1000 Factor 6.0

New Finding
 Biochemical Evidence for Translational Repression by Arabidopsis MicroRNAs.
Lanet E, Delannoy E, …, Voinnet O, Robaglia C
Plant Cell 2009 Jun 16 [abstract on PubMed] [related articles] [full text]
Selected by | Julia Kehr
Evaluated 3 Jul 2009

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F1000 Factor 3.0

Hypothesis
 The role of behaviour in evolution: a search for mechanism.
Duckworth RA
Evol Ecol 2009 23:513-531 [full text]
Selected by | Isabel M. Smallegange and Tim Coulson
Evaluated 3 Jul 2009


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