SECTION	SCOPE
Biocatalysis	Biocatalysis Enzyme complexes Enzyme engineering Enzyme mechanisms Metabolic engineering Metabolic pathways Natural products biosynthesis Novel enzyme cofactors Radicals Regulation
Bioinorganic chemistry	Biominerals & biomineralization Chemistry of NO Electron transport & oxygen metabolism Hydrolytic & water chemistry Metal ion uptake, storage, & metabolism Metal-dependent sensors/regulators Metalloenzymes with radical intermediates Metal-nucleic acid chemistry Metals & medicine Molybdenum & tungsten Nitrogen, sulfur, hydrogen, & carbon metabolism
Biomacromolecule-ligand interactions	Inhibitors Protein binding studies Structural basis of binding Theoretical aspects of binding
Biomimetic chemistry	Artificial catalysts Chemical models for biological processes Cofactor models & surrogates Dendrimers Designed complexes & arrays Micelles, liposomes, membranes Molecular computing Molecular devices & sensors Reaction networks Receptors & recognition Transport & channel design
Cell signalling & trafficking structures	Apoptotic pathways Developmental pathways Extracellular receptor ligand interactions G-protein coupled receptor signalling Intracellular receptor domain interactions Kinases & phosphatases Nuclear import/export Second messenger generation & responses Signalling in the immune system Small GTPases & their regulation Vesicle targeting & fusion
Chemical biology of the cell	Cell surface engineering Chemical genetics Intracellular monitoring Metabolic pathway engineering Modulation of signal transduction Protein-protein interactions Receptor-ligand interactions Sensors & imaging Single cell metabolite assays Transcriptional regulation & control
Directed molecular evolution	Aptamers Bioprospecting & enzyme discovery Catalytic antibodies Combinatorial biosynthesis Directed evolution Generation of diversity In vitro selection Molecular ecology Phage/ribosome display Theoretical foundations of molecular evolution
Experimental biophysical methods	Calorimetry & kinetic measurements CD, fluorescence, raman, EPR & other spectroscopy Centrifugation & hydrodynamic methods Chromatography & electrophoresis Electron microscopy Neutron scattering & diffraction NMR Scanning, tunnelling, atomic force & x-ray microscopy Single molecule methods Sub-nanosecond processes X-ray crystallography
Macromolecular assemblies & machines	Microtubules & microtubule associated proteins Multi/large enzyme complexes Muscle & muscle proteins (actin/myosin/tropomyosin/acrosomal bundle) Organelles Other macromolecules: amyloid fibres Other macromolecules: chromatin Other macromolecules: clathrin & endosomes Other macromolecules: intermediate filaments Other macromolecules: pili Other molecular machines: bacterial cell division Other molecular machines: bacterial flagella Other molecular machines: chaperones Other molecular machines: DNA packaging Other molecular machines: nuclear pore complex Other molecular machines: ribosome Other molecular machines: splicing machinery Rotary machines (ATP synthases, RNA & DNA helicases & other hexameric machines involved in DNA packaging) Viruses
Macromolecular chemistry	Carbohydrates (including glycosaminoglycans & polysaccharides) Chemical synthesis of natural & non-natural proteins Glycoproteins & glycolipids Lipids, liposomes, membranes Macromolecular arrays, synthesis & analysis of macromolecular arrays (AFM, SPR, etc., new patterning methods, etc.) Macromolecular conjugates Microarrays Non-natural biologically active polymers Non-natural glycoconjugates & glycoprotein analogs Nucleic acid analogs Nucleic acid catalysis Protein modification RNA/DNA folding
Membrane proteins & energy transduction	ABC transporters ATP synthases (F & V type) Beta-barrel membrane proteins G-protein coupled receptors & archaebacterial retinal-binding proteins Ion channels & gating: ligand-gated ion channels, voltage-gated ion channels Other channels (water, mechanosensitive, etc.) Photosynthetic membrane proteins Protein translocases P-type ATPases Respiratory chain complexes Secondary transporters Transporters in mitochondria, including uncoupling proteins
Protein chemistry & proteomics	Analysis of protein-protein interactions Folding Modification Novel drug targets Protein arrays Protein design Protein expression & secretion Protein expression mapping Protein separation & identification
Protein folding	Ab initio protein structure prediction Analysis & classification of protein folding patterns Computational models of protein folding Folding & assembly of membrane protein complexes Mechanisms of protein folding & unfolding reactions Role of extrinsic factors in protein folding reactions Statistical mechanics of protein folding Structural & dynamical analyses of partially folded proteins (e.g. molten globules & unfolded states) Thermodynamic properties of folded proteins
Small molecule chemistry	Combinatorial chemistry Discovery of natural products Lead optimisation Natural product biosynthesis Novel enzyme co-factors & mechanistic probes Screening technologies Structure based drug design
Structural genomics	Crystallization & structure determination by x-ray crystallography Database infrastructure Functional annotation of protein structures NMR spectroscopy: protein structures & innovations in HTP methods Protein production (cloning, expression, purification, biochemical characterization) Protein sequence & structure comparisons/families Target selection
Structure: RNA	Aptamers & riboswitches Cation & water interactions Cruciforms & junctions Crystal structures of RNA Drug-DNA complexes Dynamics & energetics Nucleic acid NMR Ribosome structural biology Ribozymes RNA enzymology RNA folding RNPS tRNA
Structure: replication & repair	DNA Damage DNA Damage signalling, checkpoints DNA glycosylases DNA ligases DNA polymerases DNA Recognition Enzymatic activities Helicases Nucleases Recombination proteins Single-strand Binding Topoisomerases
Structure: transcription & translation	Chromatin-modifying enzymes DNA structure DNA-modifying enzymes mRNA processing Nucleosomes & chromatin Ribosomes RNA polymerases SRP & translocons Transcription factors Transcriptional regulators tRNA synthetases
Theory & simulation	Computer simulations Electrostatic interactions Folding Free-energy changes & properties Quantum chemistry Structure prediction Supramolecular structures Water & aqueous solutions

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