SECTION	SCOPE
Cell adhesion	Adhesion in migration, angiogenesis & morphogenesis Biophysics of adhesion Cadherins & cadherin-related proteins Cell-cell junctions: cytoplasmic face Desmosomes & hemidesmosomes Extracellular matrix Focal adhesions: cytoplasmic face Gap junctions Ig CAMs & receptors Integrins Selectins Synaptic junctions Syndecans Tight junctions
Cell growth & division	Cell cycle & proteolysis Cell cycle modelling Cell cycle protein structure Checkpoints Cyclin Cdk regulation/Cdk inhibitors DNA replication G1 progression G1/S G2/M Growth Control Meiotic maturation & meiosis Mitosis Mitotic exit & cytokinesis Nutrient sensing & the cell cycle Positive & negative receptor signalling to the cell cycle Simple metazoan cell cycle Telomeres, centromeres & centrosome/spindle pole body Transcriptome analysis, nutritional sensing & the cell cycle
Cell signalling	Calcium Cell signalling in apoptosis, damage & senescence Cell signalling in cell cycle control Cytoplasmic/nuclear receptors G proteins Kinases & phosphatases: serine/threonine kinases, tyrosine kinases, phosphatases & smGTPases Lipids, inositol lipids & phosphates Modelling Nucleotides, nucleosides, amino acids & their receptors Peptide hormones, growth factors & their receptors Redox signalling Scaffolds/protein interactions Signalling & adhesion Signalling & regulation of gene expression Signalling & the cytoskeleton Small molecule targeting Technology: imaging/signalling Technology: proteomics Two-component signalling
Cellular death & stress responses	Apoptosis Caspase dependent cell death ER stress & related phenomena, including stress detection, signalling & response mechanisms Heat shock response Hypersensitivity response Non-caspase dependent cell death (e.g. in plants, or mediated by granzymes or complement), including survival/death signalling and effector mechanisms Oxidative stress Programmed cell death Responses to mis-folded proteins
Chemical biology of the cell	Cell surface engineering Chemical genetics Intracellular monitoring Metabolic pathway engineering Modulation of signal transduction Protein-protein interactions Receptor-ligand interactions Sensors & imaging Single cell metabolite assays Transcriptional regulation & control
Control of gene expression	Assembly of multi-subunit proteins Basic transcription mechanisms (initiation, promoter escape, elongation) Chromatin remodelling (SWI/SNF-like complexes, histone modification, DNA methylation) Connections among processing steps mRNA stability mRNA transport/localization Post-translational regulation of gene expression (ubiquitination, methylation, phosphorylation) RNA-protein interactions Signalling & translational control Splicing/polyadenylation Transcription activation mechanisms (transcriptional activators, mediator/coactivators) Translation mechanisms Translational regulation
Cytoskeleton	Actin assembly, dynamics & organization Cell polarity & shape Centrosome & spindle pole body Cilia & centrioles Cytokinesis Cytoskeleton & cell adhesion/migration Cytoskeleton & disease Cytoskeleton-membrane interactions Directional motility Intermediate filaments Microtubule associated proteins Microtubule motors Microtubule structure & dynamics Mitosis Mitotic spindle Motor-cargo interactions Myosin & associated proteins Signalling to the actin cytoskeleton Structure of actin & associated proteins
Developmental molecular mechanisms	Gene networks (co-ordination of multiple processes) Post-transcriptional control pathways Post-translational control pathways Signalling pathways Transcriptional control pathways
Leukocyte signalling & gene expression	B cells: antigen recognition B cells: gene expression B cells: other receptor systems CD4/CD8 Mast cells, dendritic cells & macrophages: gene expression Mast cells, dendritic cells & macrophages: receptors NK cells: receptors Platelets, neutrophils & other myeloid cells: receptors T cells: co-stimulatory receptors T cells: cytokine receptors T cells: gene expression T cells: receptors involved in antigen recognition T cells: TNF & death receptors
Membranes & sorting	Cargo sorting Caveolae, lipid rafts Channels & pumps Coat GTPases (ARFs) Epithelial cells ER quality control ER translocation Golgi apparatus Lipids & lipid traffic Membrane protein structure Mitochondria Nuclear import/export Organelle biogenesis & inheritance Organelle dynamics & movement Parasites (examples of membrane traffic as well as disease) Peroxisomes Phosphoinositides Plants Proteasomes Regulated secretion The endocytic system (receptor-mediated endocytosis, phagocytosis, endosomes, lysosomes) Vesicle budding (COPs & clathrin) Vesicle fusion (rabs, tethers & SNAREs)
Microbial growth & development	Cell cycle/division Differentiation DNA repair/recombination Responses to nutrients Responses to stress Sexual/asexual reproduction
Microbial physiology & metabolism	Cell structure & trafficking Control of gene expression Heat shock Motility Physiology & metabolism Regulation of pathways Signalling Transport/membranes
Morphogenesis & cell biology	Adhesion/cell matrix Aging/progression through life cycle Apoptosis Cell biology of organogenesis Cell cycle/growth control Cell differentiation Cell migration Cytoskeleton & cell polarity Fertilization Gastrulation Polarity-planar polarity Wound healing
Neuronal & glial cell biology	Axonal transport Basic methods/techniques Blood-brain barrier Cell adhesion/repulsion Cell death in the nervous system Cytoskeleton ECM Glia Glia/myelin-related disorders/diseases Growth cone motility Myelination Neuronal polarity & protein sorting Neuronal structure/function Neuronal-glial interactions Neuron-glia fate choices Vesicular trafficking in synaptic vesicle biogenesis & secretion
Neuronal signalling mechanisms	Calcium (stores, binding, release) Endocytosis Intracellular signalling pathways (including second messengers, G proteins) Ligand-gated channels Localization, cytoskeletal interaction, & traffic of signal components Molecular mechanisms of exocytosis Neuropharmacology (mechanisms not behavioural) Neurotransmitters/neuromodulators Neurotrophic/growth factor signalling Receptor signalling Signalling-related disorders (e.g. channelopathies) Synaptic structure/function (including LTP & other adaptive mechanisms) Transporters Voltage-gated channels
Nuclear structure & function	Centromeres Chromatin DNA repair DNA replication Higher order chromosome structure Mutation Nucleolus & nuclear bodies Recombination
Plant cell biology	Cell cycle, mitosis & cell division Cell death Cell differentiation at a cellular level Cell wall Cytokinesis Cytoskeleton Intracellular transport Ion transport Membranes Organelles Plasmodesmata Protein localization Signal transduction
Plant genetics & gene expression	Chromatin Chromosomes, including telomeres, centromeres & cytogenetics Genetics: mapping, meiotic segregation, population genetics, & QTL mapping RNA turnover Silencing & epigenetics Splicing Transcription factors Translation regulation

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