SECTION	SCOPE
Animal genetics	Animal models of disease Behavioural genetics Cloning Epigenetics Knockouts Transgenic models
Bioinformatics	Algorithms Comparative genomics Computational genomics Databases Linkage analysis Statistics of sequence comparison Structural biology
Biomacromolecule-ligand interactions	Inhibitors Protein binding studies Structural basis of binding Theoretical aspects of binding
Cell signalling & trafficking structures	Apoptotic pathways Developmental pathways Extracellular receptor ligand interactions G-protein coupled receptor signalling Intracellular receptor domain interactions Kinases & phosphatases Nuclear import/export Second messenger generation & responses Signalling in the immune system Small GTPases & their regulation Vesicle targeting & fusion
Evolutionary/comparative genetics	Comparative evolutionary genomics Evolution of genetic systems Evolutionary genetics Evolutionary genetics of phenotype Phylogenetics & taxonomy Population genetics Quantitative evolutionary genetics & QTL mapping Speciation
Experimental biophysical methods	Calorimetry & kinetic measurements CD, fluorescence, raman, EPR & other spectroscopy Centrifugation & hydrodynamic methods Chromatography & electrophoresis Electron microscopy Neutron scattering & diffraction NMR Scanning, tunnelling, atomic force & x-ray microscopy Single molecule methods Sub-nanosecond processes X-ray crystallography
Genomics	Computational analysis Expression analysis General genomics expertise High-throughput genome technology Mapping and sequencing Proteomics
Macromolecular assemblies & machines	Microtubules & microtubule associated proteins Multi/large enzyme complexes Muscle & muscle proteins (actin/myosin/tropomyosin/acrosomal bundle) Organelles Other macromolecules: amyloid fibres Other macromolecules: chromatin Other macromolecules: clathrin & endosomes Other macromolecules: intermediate filaments Other macromolecules: pili Other molecular machines: bacterial cell division Other molecular machines: bacterial flagella Other molecular machines: chaperones Other molecular machines: DNA packaging Other molecular machines: nuclear pore complex Other molecular machines: ribosome Other molecular machines: splicing machinery Rotary machines (ATP synthases, RNA & DNA helicases & other hexameric machines involved in DNA packaging) Viruses
Medical genetics	Complex & simple gene mapping Gene therapy Genetic basis of diseases Pre-/post-natal diagnosis
Membrane proteins & energy transduction	ABC transporters ATP synthases (F & V type) Beta-barrel membrane proteins G-protein coupled receptors & archaebacterial retinal-binding proteins Ion channels & gating: ligand-gated ion channels, voltage-gated ion channels Other channels (water, mechanosensitive, etc.) Photosynthetic membrane proteins Protein translocases P-type ATPases Respiratory chain complexes Secondary transporters Transporters in mitochondria, including uncoupling proteins
Microbial evolution & genomics	Bacterial comparative genomics Evolution Genetic/phenotypic diversity of bacteria, parasites & fungi Microbial genetics Phylogeny Virus evolution
Plant genomes & evolution	Evolution of developmental genes & morphology Genome evolution Genomics Organelle genomes Phylogeny of genes Phylogeny of taxa Transposons
Protein folding	Ab initio protein structure prediction Analysis & classification of protein folding patterns Computational models of protein folding Folding & assembly of membrane protein complexes Mechanisms of protein folding & unfolding reactions Role of extrinsic factors in protein folding reactions Statistical mechanics of protein folding Structural & dynamical analyses of partially folded proteins (e.g. molten globules & unfolded states) Thermodynamic properties of folded proteins
Structural genomics	Crystallization & structure determination by x-ray crystallography Database infrastructure Functional annotation of protein structures NMR spectroscopy: protein structures & innovations in HTP methods Protein production (cloning, expression, purification, biochemical characterization) Protein sequence & structure comparisons/families Target selection
Structure: RNA	Aptamers & riboswitches Cation & water interactions Cruciforms & junctions Crystal structures of RNA Drug-DNA complexes Dynamics & energetics Nucleic acid NMR Ribosome structural biology Ribozymes RNA enzymology RNA folding RNPS tRNA
Structure: replication & repair	DNA Damage DNA Damage signalling, checkpoints DNA glycosylases DNA ligases DNA polymerases DNA Recognition Enzymatic activities Helicases Nucleases Recombination proteins Single-strand Binding Topoisomerases
Structure: transcription & translation	Chromatin-modifying enzymes DNA structure DNA-modifying enzymes mRNA processing Nucleosomes & chromatin Ribosomes RNA polymerases SRP & translocons Transcription factors Transcriptional regulators tRNA synthetases
Theory & simulation	Computer simulations Electrostatic interactions Folding Free-energy changes & properties Quantum chemistry Structure prediction Supramolecular structures Water & aqueous solutions

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