Contact at vprince@uchicago.edu
Research in my lab focuses on how the primary body axis of vertebrate embryos is patterned and on the evolution of these patterning mechanisms. A major area of our interest is the Hox genes, which are implicated in regionalization of the primary body axis in all bilaterian embryos. In the lineage leading to teleosts a major gene duplication event has produced additional clusters of Hox patterning genes. We are using the zebrafish as a convenient teleost model to investigate the consequences of Hox duplication events. We also have ongoing projects to investigate regionalization of the endoderm, with special emphaisis on specification of the pancreas.

http://pondside.uchicago.edu/oba/faculty/prince_v.html

Signals from the neural crest regulate beta-cell mass in the pancreas. Nekrep N, Wang J, Miyatsuka T, German MS Development 2008 Jun 135(12):2151-60 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Chaya Kalcheim / Victoria Prince Evaluated 25 Jul 2008 Intra-endodermal interactions are required for pancreatic beta cell induction. Chung WS, Stainier DY Dev Cell 2008 Apr 14(4):582-93 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Victoria Prince Evaluated 22 May 2008 Complex regulation of cyp26a1 creates a robust retinoic acid gradient in the zebrafish embryo. White RJ, Nie Q, Lander AD, Schilling TF PLoS Biol 2007 Nov 20 5(11):e304 [abstract on PubMed] [related articles] [FREE full text] Selected by | Victoria Prince Evaluated 10 Jan 2008 The amniote primitive streak is defined by epithelial cell intercalation before gastrulation. Voiculescu O, Bertocchini F, …, Keller RE, Stern CD Nature 2007 Oct 25 449(7165):1049-52 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Thomas Lecuit / Victoria Prince / Patrick Tam / Jeffrey Axelrod Evaluated 13 Nov 2007 p53 activation by knockdown technologies. Robu ME, Larson JD, Farber SA, Ekker SC PLoS Genet 2007 May 25 3:78 [abstract on PubMed] [related articles] [FREE full text] Selected by | Victoria Prince / Derek Stemple Evaluated 28 Aug 2007 Evolutionary and biomedical insights from the rhesus macaque genome. Rhesus Macaque Genome Sequencing and Analysis Consortium, Gibbs RA, …, Smith KE, Zwieg AS Science 2007 Apr 13 316(5822):222-34 [abstract on PubMed] [related articles] [FREE full text] Selected by | Andrew S. McCallion / Victoria Prince Evaluated 19 Jul 2007 Hagfish embryology with reference to the evolution of the neural crest. Ota KG, Kuraku S, Kuratani S Nature 2007 Apr 5 446(7136):672-5 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Anthony Graham / Victoria Prince / Adam Summers Evaluated 24 Apr 2007 Organ size is limited by the number of embryonic progenitor cells in the pancreas but not the liver. Stanger BZ, Tanaka AJ, Melton DA Nature 2007 Feb 22 445(7130):886-91 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Victoria Prince / Iswar Hariharan Evaluated 15 Feb 2007 Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells. D'Amour KA, Bang AG, …, Carpenter MK, Baetge EE Nat Biotechnol 2006 Nov 24(11):1392-401 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Kenneth Zaret / Stephen Dalton / Raghavendra Mirmira / Victoria Prince Evaluated 14 Dec 2006 Reversal of Hox1 gene subfunctionalization in the mouse. Tvrdik P, Capecchi MR Dev Cell 2006 Aug 11(2):239-50 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Victoria Prince / Jean-François Brunet Evaluated 7 Sep 2006 Evolution of cis elements in the differential expression of two Hoxa2 coparalogous genes in pufferfish (Takifugu rubripes). Tümpel S, Cambronero F, Wiedemann LM, Krumlauf R Proc Natl Acad Sci U S A 2006 Apr 4 103(14):5419-24 [abstract on PubMed] [related articles] [FREE full text] Selected by | Victoria Prince Evaluated 13 Jul 2006 The vascular basement membrane: a niche for insulin gene expression and Beta cell proliferation. Nikolova G, Jabs N, …, Melton DA, Lammert E Dev Cell 2006 Mar 10(3):397-405 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Victoria Prince Evaluated 4 Apr 2006 Planar cell polarity signalling couples cell division and morphogenesis during neurulation. Ciruna B, Jenny A, …, Mlodzik M, Schier AF Nature 2006 Jan 12 439(7073):220-4 [abstract on PubMed] [related articles] [FREE full text] Selected by | Ivor Mason / Victoria Prince Evaluated 9 Feb 2006 Pleiotropic functions of a conserved insect-specific Hox peptide motif. Hittinger CT, Stern DL, Carroll SB Development 2005 Dec 132(23):5261-70 [abstract on PubMed] [related articles] [FREE full text] Selected by | Victoria Prince Evaluated 23 Nov 2005 Large-scale enhancer detection in the zebrafish genome. Ellingsen S, Laplante MA, …, Hoivik EA, Becker TS Development 2005 Sep 132(17):3799-811 [abstract on PubMed] [related articles] [FREE full text] Selected by | James Briscoe / Victoria Prince Evaluated 9 Aug 2005 Comprehensive survey of carapacial ridge-specific genes in turtle implies co-option of some regulatory genes in carapace evolution. Kuraku S, Usuda R, Kuratani S Evol Dev 2005 Jan-Feb 7(1):3-17 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Victoria Prince Evaluated 13 May 2005 A crucial interaction between embryonic red blood cell progenitors and paraxial mesoderm revealed in spadetail embryos. Rohde LA, Oates AC, Ho RK Dev Cell 2004 Aug 7(2):251-62 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Victoria Prince Evaluated 11 Mar 2005 Direct crossregulation between retinoic acid receptor {beta} and Hox genes during hindbrain segmentation. Serpente P, Tümpel S, …, Krumlauf R, Gould AP Development 2005 Feb 132(3):503-13 [abstract on PubMed] [related articles] [FREE full text] Selected by | Victoria Prince Evaluated 28 Jan 2005 Integration of anteroposterior and dorsoventral regulation of Phox2b transcription in cranial motoneuron progenitors by homeodomain proteins. Samad OA, Geisen MJ, …, Goridis C, Rijli FM Development 2004 Aug 131(16):4071-83 [abstract on PubMed] [related articles] [FREE full text] Selected by | Victoria Prince Evaluated 31 Aug 2004 The zebrafish Iroquois gene iro7 positions the r4/r5 boundary and controls neurogenesis in the rostral hindbrain. Lecaudey V, Anselme I, Rosa F, Schneider-Maunoury S Development 2004 Jul 131(13):3121-31 [abstract on PubMed] [related articles] [FREE full text] Selected by | Victoria Prince Evaluated 6 Jul 2004 Notch activation regulates the segregation and differentiation of rhombomere boundary cells in the zebrafish hindbrain. Cheng YC, Amoyel M, …, Xu Q, Wilkinson DG Dev Cell 2004 Apr 6(4):539-50 [abstract on PubMed] [related articles] [order article] Selected by | Victoria Prince Evaluated 22 Apr 2004 Opposing FGF and retinoid pathways control ventral neural pattern, neuronal differentiation, and segmentation during body axis extension. Diez del Corral R, Olivera-Martinez I, …, Maden M, Storey K Neuron 2003 Sep 25 40(1):65-79 [abstract on PubMed] [related articles] [order article] Selected by | Judith S. Eisen / Gordon Fishell / Victoria Prince / Sharon Amacher / Olivier Pourquie Evaluated 8 Dec 2003 Nkx6.1 controls migration and axon pathfinding of cranial branchio-motoneurons. Müller M, Jabs N, …, Fritzsch B, Sander M Development 2003 Dec 130(23):5815-26 [abstract on PubMed] [related articles] [FREE full text] Selected by | Victoria Prince Evaluated 22 Oct 2003 Anteroposterior patterning in hemichordates and the origins of the chordate nervous system. Lowe CJ, Wu M, …, Gerhart J, Kirschner M Cell 2003 Jun 27 113(7):853-65 [abstract on PubMed] [related articles] [order article] Selected by | Victoria Prince / Marianne Bronner-Fraser Evaluated 8 Aug 2003 Monitoring neural progenitor fate through multiple rounds of division in an intact vertebrate brain. Lyons DA, Guy AT, Clarke JD Development 2003 Aug 130(15):3427-36 [abstract on PubMed] [related articles] [FREE full text] Selected by | James Briscoe / Victoria Prince / Susan K. McConnell Evaluated 25 Jun 2003 Zebrafish prickle, a modulator of noncanonical Wnt/Fz signaling, regulates gastrulation movements. Veeman MT, Slusarski DC, …, Louie SH, Moon RT Curr Biol 2003 Apr 15 13(8):680-5 [abstract on PubMed] [related articles] [order article] Selected by | Victoria Prince / Jeffrey Axelrod Evaluated 16 May 2003 The prickle-related gene in vertebrates is essential for gastrulation cell movements. Takeuchi M, Nakabayashi J, …, Takeda H, Ueno N Curr Biol 2003 Apr 15 13(8):674-9 [abstract on PubMed] [related articles] [order article] Selected by | Victoria Prince / Jeffrey Axelrod Evaluated 15 May 2003 Coordinated temporal and spatial control of motor neuron and serotonergic neuron generation from a common pool of CNS progenitors. Pattyn A, Vallstedt A, …, Brunet JF, Ericson J Genes Dev 2003 Mar 15 17(6):729-37 [abstract on PubMed] [related articles] [FREE full text] Selected by | Victoria Prince / Judith S. Eisen Evaluated 15 Apr 2003 Genome duplication, a trait shared by 22000 species of ray-finned fish. Taylor JS, Braasch I, …, Meyer A, Van de Peer Y Genome Res 2003 Mar 13(3):382-90 [abstract on PubMed] [related articles] [FREE full text] Selected by | Victoria Prince Evaluated 14 Mar 2003

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