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Rachel Caspi
Laboratory of Immunology, NEI, NIH, Bethesda, United States of America

Faculty Member: IMMUNOLOGY > Autoimmunity [ since 23 February 2006 ]
[ Evaluations ]
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Evaluations

Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor.
Quintana FJ, Basso AS, …, Oukka M, Weiner HL
Nature 2008 May 1 453(7191):65-71 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Brigitte Huber / Bart Roep / Stefan Kaufmann / Robert Abraham / Mark Boothby / Rachel Caspi
Evaluated 24 Jun 2008


The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins.
Veldhoen M, Hirota K, …, Renauld JC, Stockinger B
Nature 2008 May 1 453(7191):106-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stefan Kaufmann / Richard Locksley / Stephen Safe / Mark Boothby / Rachel Caspi
Evaluated 24 Jun 2008


Cutting Edge: IL-27 Is a Potent Inducer of IL-10 but Not FoxP3 in Murine T Cells.
Batten M, Kljavin NM, …, de Sauvage FJ, Ghilardi N
J Immunol 2008 Mar 1 180(5):2752-6 [abstract on PubMed] [related articles] [order article]
Selected by | Rachel Caspi
Evaluated 22 Apr 2008

TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function.
Zhou L, Lopes JE, …, Ziegler SF, Littman DR
Nature 2008 Mar 26 [abstract on PubMed] [related articles] [full text]
Selected by | Rachel Caspi
Evaluated 22 Apr 2008

Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces.
Rubtsov YP, Rasmussen JP, …, Muller W, Rudensky AY
Immunity 2008 Apr 28(4):546-58 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Rachel Caspi / Kendall Smith / Deborah Fowell
Evaluated 22 Apr 2008

Induction of FOXP3 expression in naive human CD4+FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-beta dependent but does not confer a regulatory phenotype.
Tran DQ, Ramsey H, Shevach EM
Blood 2007 Oct 15 110(8):2983-90 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Rachel Caspi
Evaluated 18 Mar 2008

Human regulatory T cells inhibit polarization of T helper cells toward antigen-presenting cells via a TGF-beta-dependent mechanism.
Esquerré M, Tauzin B, …, Saoudi A, Valitutti S
Proc Natl Acad Sci U S A 2008 Feb 19 105(7):2550-5 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Rachel Caspi
Evaluated 18 Mar 2008

The contribution of transcription factor IRF1 to the interferon-gamma-interleukin 12 signaling axis and TH1 versus TH-17 differentiation of CD4+ T cells.
Kano S, Sato K, …, Kubo M, Taniguchi T
Nat Immunol 2008 Jan 9(1):34-41 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Rachel Caspi
Evaluated 28 Jan 2008

IL-35 is a novel cytokine with therapeutic effects against collagen-induced arthritis through the expansion of regulatory T cells and suppression of Th17 cells.
Niedbala W, Wei XQ, …, McInnes IB, Liew FY
Eur J Immunol 2007 Nov 37(11):3021-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Luciano Adorini / Rachel Caspi
Evaluated 28 Jan 2008

The inhibitory cytokine IL-35 contributes to regulatory T-cell function.
Collison LW, Workman CJ, …, Blumberg RS, Vignali DA
Nature 2007 Nov 22 450(7169):566-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Steve Ward / Grant Morahan / Thomas Nutman / Mark Smyth / Thomas Hunig / Barry Rouse / Anuradha Ray / Alan Landay / Rachel Caspi / Xiaojing Ma
Evaluated 28 Jan 2008

Expansion of CD4+CD25+ regulatory T cells by intravenous immunoglobulin: a critical factor in controlling experimental autoimmune encephalomyelitis.
Ephrem A, Chamat S, …, Kaveri SV, Misra N
Blood 2008 Jan 15 111(2):715-22 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Rachel Caspi
Evaluated 31 Oct 2007

IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells.
Korn T, Bettelli E, …, Oukka M, Kuchroo VK
Nature 2007 Jul 26 448(7152):484-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Torben Lund / Rachel Caspi
Evaluated 7 Aug 2007


Essential autocrine regulation by IL-21 in the generation of inflammatory T cells.
Nurieva R, Yang XO, …, Jetten AM, Dong C
Nature 2007 Jul 26 448(7152):480-3 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Torben Lund / Alan Houghton / Rachel Caspi
Evaluated 7 Aug 2007

IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways.
Zhou L, Ivanov II, …, Leonard WJ, Littman DR
Nat Immunol 2007 Sep 8(9):967-74 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Christian Engwerda / Rachel Caspi
Evaluated 7 Aug 2007


Cutting edge: regulatory T cells induce CD4+CD25-Foxp3- T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-beta.
Xu L, Kitani A, Fuss I, Strober W
J Immunol 2007 Jun 1 178(11):6725-9 [abstract on PubMed] [related articles] [order article]
Selected by | Stephen Cobbold / Rachel Caspi
Evaluated 18 Jul 2007

WASP regulates suppressor activity of human and murine CD4(+)CD25(+)FOXP3(+) natural regulatory T cells.
Marangoni F, Trifari S, …, Roncarolo MG, Dupré L
J Exp Med 2007 Feb 19 204(2):369-80 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Rachel Caspi
Evaluated 2 May 2007

The Wiskott-Aldrich syndrome protein is required for the function of CD4(+)CD25(+)Foxp3(+) regulatory T cells.
Maillard MH, Cotta-de-Almeida V, …, Bhan AK, Snapper SB
J Exp Med 2007 Feb 19 204(2):381-91 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Rachel Caspi
Evaluated 2 May 2007

A key role of leptin in the control of regulatory T cell proliferation.
De Rosa V, Procaccini C, …, La Cava A, Matarese G
Immunity 2007 Feb 26(2):241-55 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Torben Lund / Rachel Caspi / Dennis Taub
Evaluated 23 Mar 2007


Peroxisome proliferator-activated receptor (PPAR)alpha expression in T cells mediates gender differences in development of T cell-mediated autoimmunity.
Dunn SE, Ousman SS, …, Oksenberg J, Steinman L
J Exp Med 2007 Feb 19 204(2):321-30 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Rachel Caspi
Evaluated 27 Feb 2007

Plasmacytoid dendritic cells prime IL-10-producing T regulatory cells by inducible costimulator ligand.
Ito T, Yang M, …, Liu YJ, Gilliet M
J Exp Med 2007 Jan 22 204(1):105-15 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Christian Engwerda / Rachel Caspi
Evaluated 27 Feb 2007

IL-25 regulates Th17 function in autoimmune inflammation.
Kleinschek MA, Owyang AM, …, Kastelein RA, Cua DJ
J Exp Med 2007 Jan 22 204(1):161-70 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Torben Lund / Rachel Caspi / Luciano Adorini
Evaluated 25 Jan 2007

Toll-like receptor recognition regulates immunodominance in an antimicrobial CD4+ T cell response.
Yarovinsky F, Kanzler H, …, Coffman RL, Sher A
Immunity 2006 Oct 25(4):655-64 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Rachel Caspi / P'ng Loke
Evaluated 11 Dec 2006

The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells.
Ivanov II, McKenzie BS, …, Cua DJ, Littman DR
Cell 2006 Sep 22 126(6):1121-33 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Caetano Reis e Sousa / Christopher A. Hunter / Casey Weaver / Richard Williams / Dale Umetsu / Klaus Ley / Mercedes Rincon / Rachel Caspi / Fraydoon Rastinejad / Astar Winoto
Evaluated 11 Dec 2006


Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system.
Stumhofer JS, Laurence A, …, Ernst M, Hunter CA
Nat Immunol 2006 Sep 7(9):937-45 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | George Yap / Christian Engwerda / Rachel Caspi
Evaluated 31 Oct 2006

Protection from lethal septic peritonitis by neutralizing the biological function of interleukin 27.
Wirtz S, Tubbe I, …, Blumberg RS, Neurath MF
J Exp Med 2006 Aug 7 203(8):1875-81 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Rachel Caspi
Evaluated 27 Oct 2006

TNF downmodulates the function of human CD4+CD25hi T-regulatory cells.
Valencia X, Stephens G, …, Shevach EM, Lipsky PE
Blood 2006 Jul 1 108(1):253-61 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Rachel Caspi
Evaluated 14 Jul 2006

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells.
Bettelli E, Carrier Y, …, Weiner HL, Kuchroo VK
Nature 2006 May 11 441(7090):235-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Marsha Wills-Karp / Christian Engwerda / Torben Lund / Rachel Caspi / Stefan Kaufmann / Paul Gleeson / Andrew Weinberg
Evaluated 5 Jun 2006

Neuron-mediated generation of regulatory T cells from encephalitogenic T cells suppresses EAE.
Liu Y, Teige I, Birnir B, Issazadeh-Navikas S
Nat Med 2006 May 12(5):518-25 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Lieping Chen / Rachel Caspi / Hartmut Wekerle
Evaluated 5 Jun 2006

Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs.
Bresson D, Togher L, …, Herold KC, von Herrath M
J Clin Invest 2006 May 116(5):1371-81 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Rachel Caspi / Bart Roep
Evaluated 31 May 2006

Evidence for a functional second thymus in mice.
Terszowski G, Müller SM, …, Boehm T, Rodewald HR
Science 2006 Apr 14 312(5771):284-7 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Rachel Caspi / Arthur Hurwitz / Jean Pieters
Evaluated 14 Mar 2006

TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells.
Veldhoen M, Hocking RJ, …, Locksley RM, Stockinger B
Immunity 2006 Feb 24(2):179-89 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Christopher A. Hunter / Rachel Caspi / Klaus Ley / Dale Umetsu
Evaluated 14 Mar 2006

The immune paradox of sarcoidosis and regulatory T cells.
Miyara M, Amoura Z, …, Piette JC, Gorochov G
J Exp Med 2006 Feb 20 203(2):359-70 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Rachel Caspi
Evaluated 3 Mar 2006

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