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 | Benoit Coulombe
Laboratory of Gene Transcription and Proteomics, Clinical Research Institute of Montreal, Montreal, Canada | | | Faculty Member: CELL BIOLOGY > Control of gene expression [ since 11 February 2003 ] |
| | [ Biography ] [ Homepage ] [ Evaluations ] | Biography
BENOIT COULOMBE
Clinical Research Institute of Montreal
Montreal, Quebec, Canada
Tel: (514) 987-5662 / Fax: (514) 987-5663
E-mail: benoit.coulombe@ircm.qc.ca
URL: http://www.ircm.qc.ca/en/recherche/statique/unite14.html
RESEARCH INTERESTS:
My objective is to develop a detailed understanding of the mechanisms by which the information contained into the human genome is decoded to produce the mRNA molecules used for protein synthesis. More specifically, I seek to understand how the activity of RNA polymerase II is regulated by the multiple interactions of the enzyme with the DNA template, the nascent RNA and the regulatory proteins; and how RNA polymerase II interacts with other molecular machines to orchestrate nuclear processes such as pre-mRNA maturation and transport as well as DNA replication and repair. My research is directed toward both transcription of individual genes, using biochemistry and molecular biology to unravel the molecular details of the transcription reaction, and the analysis of transcription at the genome wide level, using genomics and proteomics to decipher regulatory networks of gene expression. Because transcriptional deregulations lead to diseases such as cancer and genetic dysfunctions and because many microbes use the transcription machinery of their host to transcribe and replicate their own genome, my research helps identifying novel molecular targets for drug discovery. | Home page
http://www.ircm.qc.ca/en/recherche/statique/unite14.html |
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