Born in Mexico City, 1961. MD, PhD by the National University of Mexico. Residence in Internal Medicina and Nephrology at the Instituto Nacional de la Nutrición Salvador Zubirán in Mexico City and fellow at the Brigham and Women¿s Hospital, Harvard Medical School 1990 to 1993.

Actual position: Full professor at the Instituto Nacional de la Nutrición Salvador Zubirán, Biomedical Research Institute, National University of Mexico.

Research Interest: Electroneutral cotransporters. Cyclosporine toxicity.

Grant: Mexican CONACYT, Wellcome Trust and NIH.

http://www.biomedicas.unam.mx/investigadores.asp?Signon=gamba

Caenorhabditis elegans WNK-STE20 pathway regulates tube formation by modulating ClC channel activity. Hisamoto N, Moriguchi T, …, Shibuya H, Matsumoto K EMBO Rep 2008 Jan 9(1):70-5 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Gerardo Gamba Evaluated 11 Feb 2008 Differential expression of absorptive cation-chloride-cotransporters in the intestinal and renal tissues of the European eel (Anguilla anguilla). Cutler CP, Cramb G Comp Biochem Physiol B Biochem Mol Biol 2008 Jan 149(1):63-73 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Gerardo Gamba Evaluated 22 Jan 2008 Genetic variation in the renal sodium transporters NKCC2, NCC, and ENaC in relation to the effects of loop diuretic drugs. Vormfelde SV, Sehrt D, …, Nürnberg P, Brockmöller J Clin Pharmacol Ther 2007 Sep 82(3):300-9 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Gerardo Gamba Evaluated 3 Oct 2007 Renal expression of parvalbumin is critical for NaCl handling and response to diuretics. Belge H, Gailly P, …, Bindels RJ, Devuyst O Proc Natl Acad Sci U S A 2007 Sep 11 104(37):14849-54 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Gerardo Gamba Evaluated 26 Sep 2007 A novel N-terminal isoform of the neuron-specific K-Cl cotransporter KCC2. Uvarov P, Ludwig A, …, Rivera C, Airaksinen MS J Biol Chem 2007 Oct 19 282(42):30570-6 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Gerardo Gamba / Klaus-Peter Hoffmann Evaluated 13 Sep 2007 Protein kinase WNK2 inhibits cell proliferation by negatively modulating the activation of MEK1/ERK1/2. Moniz S, Veríssimo F, …, Gespach C, Jordan P Oncogene 2007 Sep 6 26(41):6071-81 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Gerardo Gamba Evaluated 20 Aug 2007 Evolutionarily conserved WNK and Ste20 kinases are essential for acute volume recovery and survival after hypertonic shrinkage in Caenorhabditis elegans. Choe KP, Strange K Am J Physiol Cell Physiol 2007 Sep 293(3):C915-27 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Gerardo Gamba Evaluated 23 Jul 2007 Molecular pathogenesis of pseudohypoaldosteronism type II: generation and analysis of a Wnk4(D561A/+) knockin mouse model. Yang SS, Morimoto T, …, Sasaki S, Uchida S Cell Metab 2007 May 5(5):331-44 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Gerardo Gamba Evaluated 17 May 2007 WNK4 regulates activity of the epithelial Na+ channel in vitro and in vivo. Ring AM, Cheng SX, …, Hebert SC, Lifton RP Proc Natl Acad Sci U S A 2007 Mar 6 104(10):4020-4 [abstract on PubMed] [related articles] [FREE full text] Selected by | Gerardo Gamba Evaluated 13 Mar 2007 WNK4 enhances TRPV5-mediated calcium transport: potential role in hypercalciuria of familial hyperkalemic hypertension caused by gene mutation of WNK4. Jiang Y, Ferguson WB, Peng JB Am J Physiol Renal Physiol 2007 Feb 292(2):F545-54 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Gerardo Gamba Evaluated 2 Mar 2007 Aldosterone impairs vascular reactivity by decreasing glucose-6-phosphate dehydrogenase activity. Leopold JA, Dam A, …, Pitt B, Loscalzo J Nat Med 2007 Feb 13(2):189-97 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Gerardo Gamba / Morag Young / Michael Clark / Michael Frenneaux Evaluated 26 Feb 2007 Dynamics of aquaporin-2 serine-261 phosphorylation in response to short-term vasopressin treatment in collecting duct. Hoffert JD, Nielsen J, …, Nielsen S, Knepper MA Am J Physiol Renal Physiol 2007 Feb 292(2):F691-700 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Gerardo Gamba Evaluated 26 Feb 2007 Regulation of activity and localization of the WNK1 protein kinase by hyperosmotic stress. Zagórska A, Pozo-Guisado E, …, Prescott AR, Alessi DR J Cell Biol 2007 Jan 1 176(1):89-100 [abstract on PubMed] [related articles] [FREE full text] Selected by | Gerardo Gamba Evaluated 23 Jan 2007 Wnk4 controls blood pressure and potassium homeostasis via regulation of mass and activity of the distal convoluted tubule. Lalioti MD, Zhang J, …, Geller DS, Lifton RP Nat Genet 2006 Oct 38(10):1124-32 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Gerardo Gamba / David Cook Evaluated 3 Oct 2006 Emilin1 links TGF-beta maturation to blood pressure homeostasis. Zacchigna L, Vecchione C, …, Lembo G, Bressan GM Cell 2006 Mar 10 124(5):929-42 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Gerardo Gamba Evaluated 14 Sep 2006 Macula densa control of renin secretion and preglomerular resistance in mice with selective deletion of the B isoform of the Na,K,2Cl co-transporter. Oppermann M, Mizel D, …, Schnermann J, Castrop H J Am Soc Nephrol 2006 Aug 17(8):2143-52 [abstract on PubMed] [related articles] [FREE full text] Selected by | Janos Peti-Peterdi / Gerardo Gamba Evaluated 8 Sep 2006 Regulation of the expression of the Na/Cl cotransporter by WNK4 and WNK1: evidence that accelerated dynamin-dependent endocytosis is not involved. Golbang AP, Cope G, …, Cuthbert AW, O'shaughnessy KM Am J Physiol Renal Physiol 2006 Dec 291(6):F1369-76 [abstract on PubMed] [related articles] [FREE full text] Selected by | Gerardo Gamba Evaluated 8 Sep 2006 WNK1 and OSR1 regulate the Na+, K+, 2Cl- cotransporter in HeLa cells. Anselmo AN, Earnest S, …, Zhao Y, Cobb MH Proc Natl Acad Sci U S A 2006 Jul 18 103(29):10883-8 [abstract on PubMed] [related articles] [FREE full text] Selected by | Gerardo Gamba Evaluated 15 Aug 2006 Anomalous levels of Cl- transporters in the hippocampal subiculum from temporal lobe epilepsy patients make GABA excitatory. Palma E, Amici M, …, Miledi R, Eusebi F Proc Natl Acad Sci U S A 2006 May 30 103(22):8465-8 [abstract on PubMed] [related articles] [FREE full text] Selected by | Gerardo Gamba Evaluated 22 Jun 2006 WNK4 kinase regulates surface expression of the human sodium chloride cotransporter in mammalian cells. Cai H, Cebotaru V, …, Guggino SE, Guggino WB Kidney Int 2006 Jun 69(12):2162-70 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Gerardo Gamba Evaluated 18 May 2006 WNK kinases influence TRPV4 channel function and localization. Fu Y, Subramanya A, Rozansky D, Cohen DM Am J Physiol Renal Physiol 2006 Jun 290(6):F1305-14 [abstract on PubMed] [related articles] [FREE full text] Selected by | Gerardo Gamba Evaluated 17 May 2006 V1a vasopressin receptors maintain normal blood pressure by regulating circulating blood volume and baroreflex sensitivity. Koshimizu TA, Nasa Y, …, Okamura H, Tsujimoto G Proc Natl Acad Sci U S A 2006 May 16 103(20):7807-12 [abstract on PubMed] [related articles] [FREE full text] Selected by | Gerardo Gamba Evaluated 17 May 2006 cAMP increases surface expression of NKCC2 in rat thick ascending limbs: role of VAMP. Ortiz PA Am J Physiol Renal Physiol 2006 Mar 290(3):F608-16 [abstract on PubMed] [related articles] [FREE full text] Selected by | Gerardo Gamba Evaluated 17 Mar 2006 Protein kinase WNK3 increases cell survival in a caspase-3-dependent pathway. Veríssimo F, Silva E, …, Pepperkok R, Jordan P Oncogene 2006 Jul 13 25(30):4172-82 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Gerardo Gamba Evaluated 9 Mar 2006 Copy number polymorphism in Fcgr3 predisposes to glomerulonephritis in rats and humans. Aitman TJ, Dong R, …, Pusey CD, Cook HT Nature 2006 Feb 16 439(7078):851-5 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Manuel Serrano / Gerardo Gamba / Ian Dunham / Sue Malcolm Evaluated 8 Mar 2006 Neurogenic mechanisms contribute to hypertension in mice with disruption of the K-Cl cotransporter KCC3. Rust MB, Faulhaber J, …, Jentsch TJ, Hübner CA Circ Res 2006 Mar 3 98(4):549-56 [abstract on PubMed] [related articles] [FREE full text] Selected by | Gerardo Gamba Evaluated 3 Mar 2006 Antagonistic regulation of ROMK by long and kidney-specific WNK1 isoforms. Lazrak A, Liu Z, Huang CL Proc Natl Acad Sci U S A 2006 Jan 31 103(5):1615-20 [abstract on PubMed] [related articles] [FREE full text] Selected by | Gerardo Gamba / Aniko Naray-Fejes-Toth Evaluated 28 Feb 2006 A C-terminal domain in KCC2 confers constitutive K+-Cl- cotransport. Mercado A, Broumand V, …, Enck AH, Mount DB J Biol Chem 2006 Jan 13 281(2):1016-26 [abstract on PubMed] [related articles] [FREE full text] Selected by | Gerardo Gamba Evaluated 31 Jan 2006 Regulatory phosphorylation sites in the NH2 terminus of the renal Na-K-Cl cotransporter (NKCC2). Giménez I, Forbush B Am J Physiol Renal Physiol 2005 Dec 289(6):F1341-5 [abstract on PubMed] [related articles] [FREE full text] Selected by | Gerardo Gamba Evaluated 19 Jan 2006 WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1. Moriguchi T, Urushiyama S, …, Matsumoto K, Shibuya H J Biol Chem 2005 Dec 30 280(52):42685-93 [abstract on PubMed] [related articles] [FREE full text] Selected by | Gerardo Gamba Evaluated 12 Jan 2006 NKCC1 transporter facilitates seizures in the developing brain. Dzhala VI, Talos DM, …, Jensen FE, Staley KJ Nat Med 2005 Nov 11(11):1205-13 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Gerardo Gamba Evaluated 28 Nov 2005 Dominant-negative regulation of WNK1 by its kidney-specific kinase-defective isoform. Subramanya AR, Yang CL, Zhu X, Ellison DH Am J Physiol Renal Physiol 2006 Mar 290(3):F619-24 [abstract on PubMed] [related articles] [FREE full text] Selected by | Gerardo Gamba Evaluated 27 Oct 2005 Molecular mechanisms of cation transport by the renal Na+-K+-Cl- cotransporter: structural insight into the operating characteristics of the ion transport sites. Gagnon E, Bergeron MJ, …, Lefoll MH, Isenring P J Biol Chem 2005 Sep 16 280(37):32555-63 [abstract on PubMed] [related articles] [FREE full text] Selected by | Gerardo Gamba Evaluated 27 Oct 2005 WNK1 kinase polymorphism and blood pressure response to a thiazide diuretic. Turner ST, Schwartz GL, Chapman AB, Boerwinkle E Hypertension 2005 Oct 46(4):758-65 [abstract on PubMed] [related articles] [FREE full text] Selected by | Gerardo Gamba Evaluated 21 Oct 2005 The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases. Vitari AC, Deak M, Morrice NA, Alessi DR Biochem J 2005 Oct 1 391(Pt 1):17-24 [abstract on PubMed] [related articles] [FREE full text] Selected by | Gerardo Gamba Evaluated 23 Aug 2005 Nephrogenic diabetes insipidus in mice lacking all nitric oxide synthase isoforms. Morishita T, Tsutsui M, …, Nakashima Y, Yanagihara N Proc Natl Acad Sci U S A 2005 Jul 26 102(30):10616-21 [abstract on PubMed] [related articles] [FREE full text] Selected by | Gerardo Gamba Evaluated 18 Aug 2005 Volume sensitivity of cation-Cl- cotransporters is modulated by the interaction of two kinases: Ste20-related proline-alanine-rich kinase and WNK4. Gagnon KB, England R, Delpire E Am J Physiol Cell Physiol 2006 Jan 290(1):C134-42 [abstract on PubMed] [related articles] [FREE full text] Selected by | Gerardo Gamba Evaluated 18 Aug 2005 WNK1 activates SGK1 to regulate the epithelial sodium channel. Xu BE, Stippec S, …, Huang CL, Cobb MH Proc Natl Acad Sci U S A 2005 Jul 19 102(29):10315-20 [abstract on PubMed] [related articles] [FREE full text] Selected by | David Cook / Gerardo Gamba Evaluated 8 Aug 2005 Regulation of the renal thiazide-sensitive Na-Cl cotransporter, blood pressure, and natriuresis in obese Zucker rats treated with rosiglitazone. Khan O, Riazi S, …, Wade JB, Ecelbarger CA Am J Physiol Renal Physiol 2005 Aug 289(2):F442-50 [abstract on PubMed] [related articles] [FREE full text] Selected by | Gerardo Gamba Evaluated 8 Aug 2005 TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function. Reiser J, Polu KR, …, Clapham DE, Pollak MR Nat Genet 2005 Jul 37(7):739-44 [abstract on PubMed] [related articles] [FREE full text] Selected by | Gerardo Gamba Evaluated 20 Jul 2005 A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis. Winn MP, Conlon PJ, …, Vance JM, Rosenberg PB Science 2005 Jun 17 308(5729):1801-4 [abstract on PubMed] [related articles] [FREE full text] Selected by | Sue Malcolm / Gerardo Gamba Evaluated 20 Jul 2005 Oxytocin increases trust in humans. Kosfeld M, Heinrichs M, …, Fischbacher U, Fehr E Nature 2005 Jun 2 435(7042):673-6 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Kevan A. Martin / David P. Wolfer / Gerardo Gamba / William H. Colledge / Laurence H. Tecott Evaluated 24 Jun 2005 Enhanced passive Ca2+ reabsorption and reduced Mg2+ channel abundance explains thiazide-induced hypocalciuria and hypomagnesemia. Nijenhuis T, Vallon V, …, Hoenderop JG, Bindels RJ J Clin Invest 2005 Jun 115(6):1651-8 [abstract on PubMed] [related articles] [FREE full text] Selected by | Jens Leipziger / Gerardo Gamba Evaluated 17 Jun 2005 Properties of WNK1 and implications for other family members. Lenertz LY, Lee BH, …, Goldsmith EJ, Cobb MH J Biol Chem 2005 Jul 22 280(29):26653-8 [abstract on PubMed] [related articles] [FREE full text] Selected by | Gerardo Gamba Evaluated 8 Jun 2005 Thiazide-sensitive NaCl-cotransporter in the intestine: possible role of hydrochlorothiazide in the intestinal Ca2+ uptake. Bazzini C, Vezzoli V, …, Bottà G, Paulmichl M J Biol Chem 2005 May 20 280(20):19902-10 [abstract on PubMed] [related articles] [FREE full text] Selected by | Gerardo Gamba Evaluated 19 May 2005 Resolution of hypertension during pregnancy in familial hyperkalemia and hypertension with the WNK4 Q565E mutation. Mayan H, Mouallem M, …, Pauzner R, Farfel Z Am J Obstet Gynecol 2005 Feb 192(2):598-603 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Gerardo Gamba Evaluated 13 May 2005 Renalase is a novel, soluble monoamine oxidase that regulates cardiac function and blood pressure. Xu J, Li G, …, Crowley S, Desir GV J Clin Invest 2005 May 115(5):1275-80 [abstract on PubMed] [related articles] [FREE full text] Selected by | Gerardo Gamba / David Robertson Evaluated 11 May 2005 Mechanisms of WNK1 and WNK4 interaction in the regulation of thiazide-sensitive NaCl cotransport. Yang CL, Zhu X, …, Subramanya AR, Ellison DH J Clin Invest 2005 May 115(5):1379-87 [abstract on PubMed] [related articles] [FREE full text] Selected by | Gerardo Gamba Evaluated 4 May 2005 A high-salt diet stimulates thick ascending limb eNOS expression by raising medullary osmolality and increasing release of endothelin-1. Herrera M, Garvin JL Am J Physiol Renal Physiol 2005 Jan 288(1):F58-64 [abstract on PubMed] [related articles] [FREE full text] Selected by | Gerardo Gamba Evaluated 28 Apr 2005 Sodium retention in cirrhotic rats is associated with increased renal abundance of sodium transporter proteins. Fernández-Llama P, Ageloff S, …, Knepper MA, Jiménez W Kidney Int 2005 Feb 67(2):622-30 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Gerardo Gamba Evaluated 19 Apr 2005 Ren1c homozygous null mice are hypotensive and polyuric, but heterozygotes are indistinguishable from wild-type. Takahashi N, Lopez ML, …, Kim HS, Smithies O J Am Soc Nephrol 2005 Jan 16(1):125-32 [abstract on PubMed] [related articles] [FREE full text] Selected by | Gerardo Gamba Evaluated 30 Mar 2005

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