homefeedbacksupportlog on 4-Dec-2008 
  About F1000

 What is F1000 Biology?
 Key features
 How it's organized
 FAQs
 Faculties and sections
 Scope of sections
 List of Faculty Members
 The evaluation system
 Citing F1000
 Take a tour of the site
 Accessing fulltexts
 PubMed linkout
 How to subscribe
 Academic subscriptions
 Corporate subscriptions
 Try F1000 for free
 Who we are
 Media information
 Librarian resources
 Press releases
 In the press
 Developing countries
 F1000 Medicine
 Terms and conditions
 Privacy policy
 Contact us


Ed Manser
GSK-IMCB, Institute of Molecular and Cell Biology, Singapore, Singapore

Faculty Member: Cell Biology > Cell Signalling [ since 6 July 2001 ]
[ Homepage ] [ Evaluations ]
Home page

http://www.imb.a-star.edu.sg/Default.aspx?tabid=89

to email [Help]
Evaluations

Identifying specific protein interaction partners using quantitative mass spectrometry and bead proteomes.
Trinkle-Mulcahy L, Boulon S, …, Leonhardt H, Lamond A
J Cell Biol 2008 Oct 20 183(2):223-39 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ed Manser / David Andrews
Evaluated 30 Oct 2008

The pathogen protein EspF(U) hijacks actin polymerization using mimicry and multivalency.
Sallee NA, Rivera GM, …, Mayer BJ, Lim WA
Nature 2008 Aug 21 454(7207):1005-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Raphael Valdivia / Ed Manser with Zhao Zhuoshen
Evaluated 22 Oct 2008

Structural mechanism of WASP activation by the enterohaemorrhagic E. coli effector EspF(U).
Cheng HC, Skehan BM, …, Leong JM, Rosen MK
Nature 2008 Aug 21 454(7207):1009-13 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Matthias Buck / Raphael Valdivia / Ed Manser with Zhao Zhuoshen
Evaluated 22 Oct 2008

Statins alter neutrophil migration by modulating cellular Rho activity--a potential mechanism for statins-mediated pleotropic effects?
Maher BM, Dhonnchu TN, …, Wood AE, Watson RW
J Leukoc Biol 2008 Oct 7 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Ed Manser
Evaluated 22 Oct 2008

The Rho-Rock-Myosin signaling axis determines cell-cell integrity of self-renewing pluripotent stem cells.
Harb N, Archer TK, Sato N
PLoS ONE 2008 3(8):e3001 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Ed Manser
Evaluated 9 Sep 2008

Bora and the kinase Aurora A cooperatively activate the kinase Plk1 and control mitotic entry.
Seki A, Coppinger JA, …, Yates JR, Fang G
Science 2008 Jun 20 320:1655-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ed Manser with Zhao Zhuoshen / Iain Hagan / Timothy Yen
Evaluated 26 Jun 2008

Endogenous RhoG is dispensable for integrin-mediated cell spreading but contributes to Rac-independent migration.
Meller J, Vidali L, Schwartz MA
J Cell Sci 2008 Jun 15 121(Pt 12):1981-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Carol Otey / Ed Manser
Evaluated 23 Jun 2008

Rac1 accumulates in the nucleus during the G2 phase of the cell cycle and promotes cell division.
Michaelson D, Abidi W, …, Pagano M, Philips MR
J Cell Biol 2008 Apr 28 181 [abstract on PubMed] [related articles] [full text]
Selected by | Ed Manser / Vania Braga
Evaluated 7 May 2008

The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP.
Yun CH, Mengwasser KE, …, Meyerson M, Eck MJ
Proc Natl Acad Sci U S A 2008 Feb 12 105(6):2070-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ed Manser
Evaluated 26 Mar 2008

Nuclear FAK Promotes Cell Proliferation and Survival through FERM-Enhanced p53 Degradation.
Lim ST, Chen XL, …, Schlaepfer DD, Ilic D
Mol Cell 2008 Jan 18 29(1):9-22 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ed Manser
Evaluated 4 Feb 2008

The selectivity of protein kinase inhibitors: a further update.
Bain J, Plater L, …, Alessi DR, Cohen P
Biochem J 2007 Dec 15 408(3):297-315 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ed Manser / Silvio Gutkind
Evaluated 11 Dec 2007

LARG and mDia1 Link G{alpha}12/13 to Cell Polarity and Microtubule Dynamics.
Goulimari P, Knieling H, Engel U, Grosse R
Mol Biol Cell 2008 Jan 19(1):30-40 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Ed Manser
Evaluated 22 Nov 2007

Asymmetric CLASP-dependent nucleation of noncentrosomal microtubules at the trans-Golgi network.
Efimov A, Kharitonov A, …, Akhmanova A, Kaverina I
Dev Cell 2007 Jun 12(6):917-30 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Stephens / Michael Ehlers / Claire Walczak / Ed Manser / Vladimir Rodionov / Kenneth Sawin
Evaluated 1 Aug 2007

Inhibition of p21-activated kinase rescues symptoms of fragile X syndrome in mice.
Hayashi ML, Rao BS, …, Chattarji S, Tonegawa S
Proc Natl Acad Sci U S A 2007 Jul 3 104(27):11489-94 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Ed Manser / Jonathan Chernoff / Giovanni Neri / Gary Bokoch
Evaluated 29 Jun 2007

Fez1/Lzts1 absence impairs Cdk1/Cdc25C interaction during mitosis and predisposes mice to cancer development.
Vecchione A, Baldassarre G, …, Donovan PJ, Croce CM
Cancer Cell 2007 Mar 11(3):275-89 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ed Manser
Evaluated 8 Jun 2007

Rho GTPases regulate PRK2/PKN2 to control entry into mitosis and exit from cytokinesis.
Schmidt A, Durgan J, Magalhaes A, Hall A
EMBO J 2007 Mar 21 26(6):1624-36 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ed Manser
Evaluated 16 Apr 2007

Mitosis-specific MPM-2 phosphorylation of DNA topoisomerase IIalpha is regulated directly by protein phosphatase 2A.
Escargueil AE, Larsen AK
Biochem J 2007 Apr 15 403(2):235-42 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Ed Manser
Evaluated 11 Apr 2007

Polymerizing actin fibers position integrins primed to probe for adhesion sites.
Galbraith CG, Yamada KM, Galbraith JA
Science 2007 Feb 16 315(5814):992-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martin Humphries / Ed Manser
Evaluated 6 Mar 2007

A Rac-cGMP signaling pathway.
Guo D, Tan YC, …, Zhang JJ, Huang XY
Cell 2007 Jan 26 128(2):341-55 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ed Manser
Evaluated 13 Feb 2007

Rac1 and a GTPase-activating protein, MgcRacGAP, are required for nuclear translocation of STAT transcription factors.
Kawashima T, Bao YC, …, Williams DA, Kitamura T
J Cell Biol 2006 Dec 18 175(6):937-46 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Martin A. Schwartz / Ed Manser / Brent Cochran
Evaluated 11 Jan 2007

Centrosome polarization delivers secretory granules to the immunological synapse.
Stinchcombe JC, Majorovits E, …, Fuller S, Griffiths GM
Nature 2006 Sep 28 443(7110):462-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Stephen Doxsey / Ed Manser
Evaluated 14 Nov 2006

Perturbing integrin function inhibits microtubule growth from centrosomes, spindle assembly, and cytokinesis.
Reverte CG, Benware A, Jones CW, LaFlamme SE
J Cell Biol 2006 Aug 14 174(4):491-7 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Ed Manser / Michael Glotzer / James Bamburg
Evaluated 15 Sep 2006

The G protein G alpha(13) is required for growth factor-induced cell migration.
Shan D, Chen L, …, Gu JL, Huang XY
Dev Cell 2006 Jun 10(6):707-18 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Carole Parent / Ed Manser
Evaluated 18 Jul 2006

Axonal transport of mitochondria requires milton to recruit kinesin heavy chain and is light chain independent.
Glater EE, Megeath LJ, Stowers RS, Schwarz TL
J Cell Biol 2006 May 22 173(4):545-57 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Ed Manser
Evaluated 2 Jun 2006

JNK1 phosphorylation of SCG10 determines microtubule dynamics and axodendritic length.
Tararuk T, Ostman N, …, Courtney MJ, Coffey ET
J Cell Biol 2006 Apr 24 173(2):265-77 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Ed Manser
Evaluated 27 Apr 2006

Rac GTPase signaling through the PP5 protein phosphatase.
Gentile S, Darden T, …, Rossie S, Armstrong DL
Proc Natl Acad Sci U S A 2006 Mar 28 103(13):5202-6 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Ed Manser
Evaluated 5 Apr 2006

PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis.
Bivona TG, Quatela SE, …, Cox AD, Philips MR
Mol Cell 2006 Feb 17 21(4):481-93 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Surender Kharbanda / Ed Manser / Alfred Wittinghofer
Evaluated 9 Mar 2006

Role of p21-activated kinase pathway defects in the cognitive deficits of Alzheimer disease.
Zhao L, Ma QL, …, Frautschy SA, Cole GM
Nat Neurosci 2006 Feb 9(2):234-42 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ed Manser / Jonathan Chernoff
Evaluated 8 Feb 2006

Stat3 regulates microtubules by antagonizing the depolymerization activity of stathmin.
Ng DC, Lin BH, …, Poli V, Cao X
J Cell Biol 2006 Jan 16 172(2):245-57 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Ed Manser / Machiko Ikegami
Evaluated 26 Jan 2006

RanBP3 enhances nuclear export of active (beta)-catenin independently of CRM1.
Hendriksen J, Fagotto F, …, Noordermeer J, Fornerod M
J Cell Biol 2005 Dec 5 171(5):785-97 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Ed Manser
Evaluated 5 Dec 2005

An electrostatic steering mechanism of Cdc42 recognition by Wiskott-Aldrich syndrome proteins.
Hemsath L, Dvorsky R, …, Carlier MF, Ahmadian MR
Mol Cell 2005 Oct 28 20(2):313-24 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ed Manser
Evaluated 1 Nov 2005

Support for the immortal strand hypothesis: neural stem cells partition DNA asymmetrically in vitro.
Karpowicz P, Morshead C, …, Cheng V, van der Kooy D
J Cell Biol 2005 Aug 29 170(5):721-32 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Ed Manser
Evaluated 5 Sep 2005

Cdc42 is not essential for filopodium formation, directed migration, cell polarization, and mitosis in fibroblastoid cells.
Czuchra A, Wu X, …, Rottner K, Brakebusch C
Mol Biol Cell 2005 Oct 16(10):4473-84 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Ed Manser / Mark Ginsberg / Anne Ridley / Martin A. Schwartz
Evaluated 25 Jul 2005

A microtubule-dependent zone of active RhoA during cleavage plane specification.
Bement WM, Benink HA, von Dassow G
J Cell Biol 2005 Jul 4 170(1):91-101 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Ed Manser / Leah Keshet
Evaluated 21 Jul 2005

Nuclear movement regulated by Cdc42, MRCK, myosin, and actin flow establishes MTOC polarization in migrating cells.
Gomes ER, Jani S, Gundersen GG
Cell 2005 May 6 121(3):451-63 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ed Manser / Orly Reiner / Keith Mostov / Shu Chien
Evaluated 20 May 2005

An alpha4 integrin-paxillin-Arf-GAP complex restricts Rac activation to the leading edge of migrating cells.
Nishiya N, Kiosses WB, Han J, Ginsberg MH
Nat Cell Biol 2005 Apr 7(4):343-52 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ed Manser
Evaluated 26 Apr 2005

Phospholipase Cgamma1 controls surface expression of TRPC3 through an intermolecular PH domain.
van Rossum DB, Patterson RL, …, Gill DL, Snyder SH
Nature 2005 Mar 3 434(7029):99-104 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Mark Lemmon / Kees Jalink / Ed Manser / Stanley Froehner
Evaluated 5 Apr 2005

Raf-1 regulates Rho signaling and cell migration.
Ehrenreiter K, Piazzolla D, …, Leung T, Baccarini M
J Cell Biol 2005 Mar 14 168(6):955-64 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Ed Manser / Michael Weber
Evaluated 15 Mar 2005

The Cool-2/alpha-Pix protein mediates a Cdc42-Rac signaling cascade.
Baird D, Feng Q, Cerione RA
Curr Biol 2005 Jan 11 15(1):1-10 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ed Manser / Leah Keshet
Evaluated 15 Feb 2005

Force measurements in E-cadherin-mediated cell doublets reveal rapid adhesion strengthened by actin cytoskeleton remodeling through Rac and Cdc42.
Chu YS, Thomas WA, …, Thiery JP, Dufour S
J Cell Biol 2004 Dec 20 167(6):1183-94 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Ed Manser / Yoshimi Takai / Vania Braga / Frans Van Roy / Avri Ben-Ze'ev
Evaluated 6 Jan 2005

Rho GTPases regulate axon growth through convergent and divergent signaling pathways.
Ng J, Luo L
Neuron 2004 Dec 2 44(5):779-93 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Manzoor Bhat / Ed Manser / Paul Garrity
Evaluated 16 Dec 2004

A transmigratory cup in leukocyte diapedesis both through individual vascular endothelial cells and between them.
Carman CV, Springer TA
J Cell Biol 2004 Oct 25 167(2):377-88 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Manfred Schliwa / Ed Manser
Evaluated 15 Nov 2004

Centrosomes direct cell polarity independently of microtubule assembly in C. elegans embryos.
Cowan CR, Hyman AA
Nature 2004 Sep 2 431(7004):92-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Joel Rothman / Ed Manser / Berl R. Oakley / Bodo Lange / Michael Glotzer
Evaluated 4 Oct 2004

RhoH is required to maintain the integrin LFA-1 in a nonadhesive state on lymphocytes.
Cherry LK, Li X, …, Lim B, Klickstein LB
Nat Immunol 2004 Sep 5(9):961-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ed Manser
Evaluated 7 Sep 2004

EB1 and APC bind to mDia to stabilize microtubules downstream of Rho and promote cell migration.
Wen Y, Eng CH, …, Alberts AS, Gundersen GG
Nat Cell Biol 2004 Sep 6(9):820-30 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ed Manser
Evaluated 26 Aug 2004

A role for Drosophila IAP1-mediated caspase inhibition in Rac-dependent cell migration.
Geisbrecht ER, Montell DJ
Cell 2004 Jul 9 118(1):111-25 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Sharad Kumar / Ed Manser / Kristin White
Evaluated 23 Jul 2004

The role of substrate curvature in actin-based pushing forces.
Schwartz IM, Ehrenberg M, Bindschadler M, McGrath JL
Curr Biol 2004 Jun 22 14(12):1094-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Murray Stewart / Ed Manser / Jonathan Scholey
Evaluated 20 Jul 2004

Fascin-mediated propulsion of Listeria monocytogenes independent of frequent nucleation by the Arp2/3 complex.
Brieher WM, Coughlin M, Mitchison TJ
J Cell Biol 2004 Apr 26 165(2):233-42 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Ed Manser / R. Dyche Mullins / Linda Wordeman
Evaluated 7 May 2004

A role for the actin cytoskeleton in cell death and aging in yeast.
Gourlay CW, Carpp LN, …, Winder SJ, Ayscough KR
J Cell Biol 2004 Mar 15 164(6):803-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Ed Manser / Thomas Nystrom
Evaluated 31 Mar 2004

LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex.
Mi S, Lee X, …, McCoy JM, Pepinsky RB
Nat Neurosci 2004 Mar 7(3):221-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Phil Barker / Ed Manser
Evaluated 9 Mar 2004

Localized stabilization of microtubules by integrin- and FAK-facilitated Rho signaling.
Palazzo AF, Eng CH, …, Marcantonio EE, Gundersen GG
Science 2004 Feb 6 303(5659):836-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Orly Reiner / Kermit Carraway / Ed Manser / Martin Humphries
Evaluated 24 Feb 2004

Tyrosine phosphorylation of type Igamma phosphatidylinositol phosphate kinase by Src regulates an integrin-talin switch.
Ling K, Doughman RL, …, Schaller MD, Anderson RA
J Cell Biol 2003 Dec 22 163(6):1339-49 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Ed Manser / Filippo Giancotti
Evaluated 6 Jan 2004

Merlin, the product of the Nf2 tumor suppressor gene, is an inhibitor of the p21-activated kinase, Pak1.
Kissil JL, Wilker EW, …, Yaffe MB, Jacks T
Mol Cell 2003 Oct 12(4):841-9 [abstract on PubMed] [related articles] [order article]
Selected by | Ed Manser
Evaluated 7 Nov 2003

Molecular requirements for actin-based lamella formation in Drosophila S2 cells.
Rogers SL, Wiedemann U, Stuurman N, Vale RD
J Cell Biol 2003 Sep 15 162(6):1079-88 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Ed Manser / Denise Montell
Evaluated 29 Sep 2003

Pyk2 regulates multiple signaling events crucial for macrophage morphology and migration.
Okigaki M, Davis C, …, Sheetz MP, Schlessinger J
Proc Natl Acad Sci U S A 2003 Sep 16 100(19):10740-5 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Ed Manser
Evaluated 25 Sep 2003

Pak1 and PIX regulate contact inhibition during epithelial wound healing.
Zegers MM, Forget MA, …, ter Beest MB, Hansen SH
EMBO J 2003 Aug 15 22(16):4155-65 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Ed Manser
Evaluated 29 Aug 2003

Role of ERas in promoting tumour-like properties in mouse embryonic stem cells.
Takahashi K, Mitsui K, Yamanaka S
Nature 2003 May 29 423(6939):541-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ed Manser
Evaluated 20 Jun 2003

Regulation of leading edge microtubule and actin dynamics downstream of Rac1.
Wittmann T, Bokoch GM, Waterman-Storer CM
J Cell Biol 2003 Jun 9 161(5):845-51 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Linda Wordeman / Ed Manser / Manfred Schliwa / Vladimir Rodionov
Evaluated 19 Jun 2003

Cadherin engagement inhibits RhoA via p190RhoGAP.
Noren NK, Arthur WT, Burridge K
J Biol Chem 2003 Apr 18 278(16):13615-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Ed Manser
Evaluated 14 Mar 2003

Redox-dependent downregulation of Rho by Rac.
Nimnual AS, Taylor LJ, Bar-Sagi D
Nat Cell Biol 2003 Mar 5(3):236-41 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Anne Ridley / Ed Manser / Giorgio Berton
Evaluated 6 Mar 2003

Mechanism of filopodia initiation by reorganization of a dendritic network.
Svitkina TM, Bulanova EA, …, Vasiliev JM, Borisy GG
J Cell Biol 2003 Feb 3 160(3):409-21 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Marie-France Carlier / Ed Manser / Anthony Koleske / Buzz Baum
Evaluated 11 Feb 2003

Spatial and temporal analysis of Rac activation during live neutrophil chemotaxis.
Gardiner EM, Pestonjamasp KN, …, Hahn KM, Bokoch GM
Curr Biol 2002 Dec 10 12(23):2029-34 [abstract on PubMed] [related articles] [order article]
Selected by | Ed Manser / Steve Ward
Evaluated 6 Jan 2003

XPak3 promotes cell cycle withdrawal during primary neurogenesis in Xenopus laevis.
Souopgui J, Sölter M, Pieler T
EMBO J 2002 Dec 2 21(23):6429-39 [abstract on PubMed] [related articles] [order article]
Selected by | Ed Manser
Evaluated 5 Dec 2002

CNS integrins switch growth factor signalling to promote target-dependent survival.
Colognato H, Baron W, …, Georges-Labouesse E, ffrench-Constant C
Nat Cell Biol 2002 Nov 4(11):833-41 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ed Manser / Christopher Marshall / Charles Streuli
Evaluated 11 Nov 2002