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Jonathan Gleadle
The Henry Wellcome Centre of Molecular Physiology, Oxford, United Kingdom

Faculty Member: CELL BIOLOGY > Control of gene expression [ since 10 February 2003 ]
[ Evaluations ]
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Evaluations

Mitochondrial autophagy is a HIF-1-dependent adaptive metabolic response to hypoxia.
Zhang H, Bosch-Marce M, …, Gonzalez FJ, Semenza GL
J Biol Chem 2008 Feb 15 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jonathan Gleadle
Evaluated 7 Apr 2008

Hypoxic preconditioning requires the apoptosis protein CED-4 in C. elegans.
Dasgupta N, Patel AM, Scott BA, Crowder CM
Curr Biol 2007 Nov 20 17(22):1954-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jonathan Gleadle
Evaluated 23 Nov 2007

Development of cytosolic hypoxia and hypoxia-inducible factor stabilization are facilitated by aquaporin-1 expression.
Echevarría M, Muñoz-Cabello AM, …, Toledo-Aral JJ, López-Barneo J
J Biol Chem 2007 Oct 12 282(41):30207-15 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jonathan Gleadle
Evaluated 9 Aug 2007

Acute postnatal ablation of Hif-2alpha results in anemia.
Gruber M, Hu CJ, …, Keith B, Simon MC
Proc Natl Acad Sci U S A 2007 Feb 13 104(7):2301-6 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jonathan Gleadle
Evaluated 14 Feb 2007

Loss of the tumor suppressor Vhlh leads to upregulation of Cxcr4 and rapidly progressive glomerulonephritis in mice.
Ding M, Cui S, …, Kretzler M, Quaggin SE
Nat Med 2006 Sep 12(9):1081-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jonathan Gleadle
Evaluated 23 Nov 2006


Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2).
McDonough MA, Li V, …, Syed RS, Schofield CJ
Proc Natl Acad Sci U S A 2006 Jun 27 103(26):9814-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jonathan Gleadle / Michael Maroney
Evaluated 23 Jun 2006

p53 regulates mitochondrial respiration.
Matoba S, Kang JG, …, Bunz F, Hwang PM
Science 2006 Jun 16 312(5780):1650-3 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Anthony Means / Jonathan Gleadle / Axel Nohturfft / Peter Wipf / Philip Tsichlis / Ulf Pettersson
Evaluated 20 Jun 2006

A family with erythrocytosis establishes a role for prolyl hydroxylase domain protein 2 in oxygen homeostasis.
Percy MJ, Zhao Q, …, McMullin MF, Lee FS
Proc Natl Acad Sci U S A 2006 Jan 17 103(3):654-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jonathan Gleadle
Evaluated 6 Mar 2006

Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer.
Lee S, Nakamura E, …, Kaelin WG, Schlisio S
Cancer Cell 2005 Aug 8(2):155-67 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jonathan Gleadle / Len Neckers
Evaluated 31 Aug 2005

OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha.
Baek JH, Mahon PC, …, Giaccia AJ, Semenza GL
Mol Cell 2005 Feb 18 17(4):503-12 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jonathan Gleadle / Ronald Conaway
Evaluated 2 Mar 2005

Hemoxygenase-2 is an oxygen sensor for a calcium-sensitive potassium channel.
Williams SE, Wootton P, …, Peers C, Kemp PJ
Science 2004 Dec 17 306(5704):2093-7 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jonathan Gleadle / Ardem Patapoutian / Angela Wilks
Evaluated 11 Nov 2004

Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway.
Kung AL, Zabludoff SD, …, Wood AW, Livingston DM
Cancer Cell 2004 Jul 6(1):33-43 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jonathan Gleadle / Carlos F. Barbas
Evaluated 11 Aug 2004

Oxygen sensation and social feeding mediated by a C. elegans guanylate cyclase homologue.
Gray JM, Karow DS, …, Marletta MA, Bargmann CI
Nature 2004 Jul 15 430(6997):317-22 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jonathan Gleadle
Evaluated 20 Jul 2004

HIF activation by pH-dependent nucleolar sequestration of VHL.
Mekhail K, Gunaratnam L, Bonicalzi ME, Lee S
Nat Cell Biol 2004 Jul 6(7):642-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ronald Conaway / Jonathan Gleadle / Marie-Alda Gilles-Gonzalez / William Kaelin
Evaluated 21 Jun 2004

Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors.
He W, Miao FJ, …, Tian H, Ling L
Nature 2004 May 13 429(6988):188-93 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jonathan Gleadle / Deborah Andrew
Evaluated 18 May 2004

Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1-/- mice.
Scortegagna M, Ding K, …, Bennett MJ, Garcia JA
Nat Genet 2003 Dec 35(4):331-40 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jonathan Gleadle
Evaluated 24 Nov 2003

Molecular identification of a danger signal that alerts the immune system to dying cells.
Shi Y, Evans JE, Rock KL
Nature 2003 Oct 2 425(6957):516-21 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Caetano Reis e Sousa / Allan Zajac / Jonathan Gleadle / Michael Gold / Michael McHeyzer-Williams / David Branch Moody / Stefan Kaufmann / Matthias von Herrath / Luis J. Montaner / Richard Vile
Evaluated 10 Oct 2003

TSC2 regulates VEGF through mTOR-dependent and -independent pathways.
Brugarolas JB, Vazquez F, …, Sellers WR, Kaelin WG
Cancer Cell 2003 Aug 4(2):147-58 [abstract on PubMed] [related articles] [order article]
Selected by | Jonathan Gleadle
Evaluated 12 Sep 2003

Oxygen and iron regulation of iron regulatory protein 2.
Hanson ES, Rawlins ML, Leibold EA
J Biol Chem 2003 Oct 10 278(41):40337-42 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jonathan Gleadle / Christopher Schofield
Evaluated 14 Aug 2003

Mutations of von Hippel-Lindau tumor-suppressor gene and congenital polycythemia.
Pastore Y, Jedlickova K, …, Prchal JF, Prchal JT
Am J Hum Genet 2003 Aug 73(2):412-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jonathan Gleadle
Evaluated 9 Jul 2003

CD2-associated protein haploinsufficiency is linked to glomerular disease susceptibility.
Kim JM, Wu H, …, Unanue ER, Shaw AS
Science 2003 May 23 300(5623):1298-300 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jonathan Gleadle
Evaluated 30 May 2003

von Hippel-Lindau protein binds hyperphosphorylated large subunit of RNA polymerase II through a proline hydroxylation motif and targets it for ubiquitination.
Kuznetsova AV, Meller J, …, Conaway RC, Czyzyk-Krzeska MF
Proc Natl Acad Sci U S A 2003 Mar 4 100(5):2706-11 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jonathan Gleadle
Evaluated 14 Mar 2003

Iron regulatory protein 2 as iron sensor. Iron-dependent oxidative modification of cysteine.
Kang DK, Jeong J, …, Rouault TA, Levine RL
J Biol Chem 2003 Apr 25 278(17):14857-64 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jonathan Gleadle
Evaluated 24 Feb 2003

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