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Andrew D. Sharrocks
School of Biological Sciences, University of Manchester, Manchester, United Kingdom

Faculty Member: CELL BIOLOGY > Control of gene expression [ since 3 September 2001 ]
[ Sponsorship ] [ Homepage ] [ Evaluations ]
Sponsorship

Andrew D. Sharrocks sponsors free access to F1000 for The International Livestock Research Institute, Addis Ababa, Ethiopia. Supporting F1000's initiative to make itself available to scientists in all countries, including free access to developing countries (more details).

Home page

http://www.ls.manchester.ac.uk/people/profile/?id=889

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Evaluations

Arsenic degrades PML or PML-RARalpha through a SUMO-triggered RNF4/ubiquitin-mediated pathway.
Lallemand-Breitenbach V, Jeanne M, …, Raught B, de Thé H
Nat Cell Biol 2008 May 10(5):547-55 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Andrew D. Sharrocks
Evaluated 30 Jun 2008

Novel transcription-factor-like function of human matrix metalloproteinase 3 regulating the CTGF/CCN2 gene.
Eguchi T, Kubota S, …, Kuboki T, Takigawa M
Mol Cell Biol 2008 Apr 28(7):2391-413 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Andrew D. Sharrocks
Evaluated 20 Jun 2008

Chromatin decouples promoter threshold from dynamic range.
Lam FH, Steger DJ, O'Shea EK
Nature 2008 May 8 453(7192):246-50 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jeffrey Hayes / Andrew D. Sharrocks / Oliver Rando
Evaluated 21 May 2008

Yeast Mpk1 mitogen-activated protein kinase activates transcription through Swi4/Swi6 by a noncatalytic mechanism that requires upstream signal.
Kim KY, Truman AW, Levin DE
Mol Cell Biol 2008 Apr 28(8):2579-89 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Andrew D. Sharrocks
Evaluated 19 May 2008

RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation.
Tatham MH, Geoffroy MC, …, Palvimo JJ, Hay RT
Nat Cell Biol 2008 May 10(5):538-46 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Andrew D. Sharrocks
Evaluated 21 Apr 2008

FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription.
Lupien M, Eeckhoute J, …, Liu XS, Brown M
Cell 2008 Mar 21 132(6):958-70 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Andrew D. Sharrocks / Susan Mango
Evaluated 2 Apr 2008

Cyclical DNA methylation of a transcriptionally active promoter.
Métivier R, Gallais R, …, Gannon F, Salbert G
Nature 2008 Mar 6 452(7183):45-50 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Andrew D. Sharrocks / Anjana Rao
Evaluated 20 Mar 2008


Transient cyclical methylation of promoter DNA.
Kangaspeska S, Stride B, …, Gannon F, Reid G
Nature 2008 Mar 6 452(7183):112-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Andrew D. Sharrocks
Evaluated 20 Mar 2008

Differential display of DNA-binding proteins reveals heat-shock factor 1 as a circadian transcription factor.
Reinke H, Saini C, …, Benjamin IJ, Schibler U
Genes Dev 2008 Feb 1 22(3):331-45 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Cheng-Ming Chiang / Andrew D. Sharrocks / Mark Caddick
Evaluated 14 Feb 2008

SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia.
Cheng J, Kang X, Zhang S, Yeh ET
Cell 2007 Nov 2 131(3):584-95 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Andrew D. Sharrocks
Evaluated 30 Jan 2008

Genome-wide mapping of RELA(p65) binding identifies E2F1 as a transcriptional activator recruited by NF-kappaB upon TLR4 activation.
Lim CA, Yao F, …, Ruan Y, Chin KC
Mol Cell 2007 Aug 17 27(4):622-35 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Denis Guttridge / Andrew D. Sharrocks
Evaluated 24 Jan 2008

Transcription of histone gene cluster by differential core-promoter factors.
Isogai Y, Keles S, …, Hochheimer A, Tjian R
Genes Dev 2007 Nov 15 21(22):2936-49 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Andrew D. Sharrocks
Evaluated 7 Dec 2007

Cooperative interactions between CBP and TORC2 confer selectivity to CREB target gene expression.
Ravnskjaer K, Kester H, …, Yates JR, Montminy M
EMBO J 2007 Jun 20 26(12):2880-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Andrew D. Sharrocks
Evaluated 7 Dec 2007

An elaborate pathway required for Ras-mediated epigenetic silencing.
Gazin C, Wajapeyee N, …, Virbasius CM, Green MR
Nature 2007 Oct 25 449(7165):1073-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Charles Brenner / Andrew D. Sharrocks / Michael Meisterernst / Igor Stagljar
Evaluated 6 Dec 2007

SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation.
Vaquero A, Scher M, …, Serrano L, Reinberg D
Nature 2007 Nov 15 450(7168):440-4 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Andrew D. Sharrocks
Evaluated 28 Nov 2007

Temporal ChIP-on-chip reveals Biniou as a universal regulator of the visceral muscle transcriptional network.
Jakobsen JS, Braun M, …, Carlsson P, Furlong EE
Genes Dev 2007 Oct 1 21(19):2448-60 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Andrew D. Sharrocks
Evaluated 22 Oct 2007

Switching of the core transcription machinery during myogenesis.
Deato MD, Tjian R
Genes Dev 2007 Sep 1 21(17):2137-49 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Denis Guttridge / Simon Hughes / Tony Weil / Andrew D. Sharrocks
Evaluated 13 Sep 2007

p21 transcription is regulated by differential localization of histone H2A.Z.
Gévry N, Chan HM, …, Livingston DM, Gaudreau L
Genes Dev 2007 Aug 1 21(15):1869-81 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Andrew D. Sharrocks
Evaluated 13 Sep 2007

Distinct classes of chromosomal rearrangements create oncogenic ETS gene fusions in prostate cancer.
Tomlins SA, Laxman B, …, Mehra R, Chinnaiyan AM
Nature 2007 Aug 2 448(7153):595-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Andrew D. Sharrocks
Evaluated 30 Aug 2007

Genome-wide analyses reveal properties of redundant and specific promoter occupancy within the ETS gene family.
Hollenhorst PC, Shah AA, Hopkins C, Graves BJ
Genes Dev 2007 Aug 1 21(15):1882-94 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Andrew D. Sharrocks
Evaluated 22 Aug 2007

Proinflammatory stimuli induce IKKalpha-mediated phosphorylation of PIAS1 to restrict inflammation and immunity.
Liu B, Yang Y, …, Loo JA, Shuai K
Cell 2007 Jun 1 129(5):903-14 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Andrew D. Sharrocks
Evaluated 6 Jul 2007

A microRNA component of the p53 tumour suppressor network.
He L, He X, …, Cleary MA, Hannon GJ
Nature 2007 Jun 28 447(7148):1130-4 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | W. Brent Derry / Andrew D. Sharrocks
Evaluated 5 Jul 2007

A mechanism for cell-cycle regulation of MAP kinase signaling in a yeast differentiation pathway.
Strickfaden SC, Winters MJ, …, Tyers M, Pryciak PM
Cell 2007 Feb 9 128(3):519-31 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Linda Huang / Andrew D. Sharrocks
Evaluated 18 Jun 2007

Opposing LSD1 complexes function in developmental gene activation and repression programmes.
Wang J, Scully K, …, Fu XD, Rosenfeld MG
Nature 2007 Apr 19 446(7138):882-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Andrew D. Sharrocks
Evaluated 1 May 2007

Regulation of the G2-M cell cycle progression by the ERK5-NFkappaB signaling pathway.
Cude K, Wang Y, …, Wang CY, Xia Z
J Cell Biol 2007 Apr 23 177(2):253-64 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Andrew D. Sharrocks
Evaluated 27 Apr 2007

HDAC1 acetylation is linked to progressive modulation of steroid receptor-induced gene transcription.
Qiu Y, Zhao Y, …, Schiltz RL, Hager GL
Mol Cell 2006 Jun 9 22(5):669-79 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Andrew D. Sharrocks
Evaluated 19 Mar 2007

A core transcriptional network for early mesoderm development in Drosophila melanogaster.
Sandmann T, Girardot C, …, Stolc V, Furlong EE
Genes Dev 2007 Feb 15 21(4):436-49 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Siegfried Roth / Andrew D. Sharrocks
Evaluated 19 Mar 2007

The role of the proteasomal ATPases and activator monoubiquitylation in regulating Gal4 binding to promoters.
Ferdous A, Sikder D, …, Kodadek T, Johnston SA
Genes Dev 2007 Jan 1 21(1):112-23 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Andrew D. Sharrocks / Mark Caddick
Evaluated 2 Feb 2007

Phosphorylation of p38 by GRK2 at the docking groove unveils a novel mechanism for inactivating p38MAPK.
Peregrin S, Jurado-Pueyo M, …, Mayor F, Murga C
Curr Biol 2006 Oct 24 16(20):2042-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Angel Nebreda / Andrew D. Sharrocks
Evaluated 10 Jan 2007

CK2 controls the recruitment of Wnt regulators to target genes in vivo.
Wang S, Jones KA
Curr Biol 2006 Nov 21 16(22):2239-44 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Andrew D. Sharrocks
Evaluated 3 Jan 2007

Constraining G1-specific transcription to late G1 phase: the MBF-associated corepressor Nrm1 acts via negative feedback.
de Bruin RA, Kalashnikova TI, …, Russell P, Wittenberg C
Mol Cell 2006 Aug 23(4):483-96 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Linda Breeden / Andrew D. Sharrocks
Evaluated 23 Nov 2006

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
Olsen JV, Blagoev B, …, Mortensen P, Mann M
Cell 2006 Nov 3 127(3):635-48 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Andrew D. Sharrocks / Karen Anderson / Channing Der
Evaluated 8 Nov 2006

Evolution of alternative transcriptional circuits with identical logic.
Tsong AE, Tuch BB, Li H, Johnson AD
Nature 2006 Sep 28 443(7110):415-20 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Andrew D. Sharrocks / David Soll
Evaluated 19 Oct 2006

The stress-activated Hog1 kinase is a selective transcriptional elongation factor for genes responding to osmotic stress.
Proft M, Mas G, …, Struhl K, Posas F
Mol Cell 2006 Jul 21 23(2):241-50 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Andrew D. Sharrocks
Evaluated 19 Oct 2006

Dynamics of heat shock factor association with native gene loci in living cells.
Yao J, Munson KM, Webb WW, Lis JT
Nature 2006 Aug 31 442(7106):1050-3 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ilaria Rebay / Andrew D. Sharrocks
Evaluated 8 Sep 2006

Proteolytic turnover of the Gal4 transcription factor is not required for function in vivo.
Nalley K, Johnston SA, Kodadek T
Nature 2006 Aug 31 442(7106):1054-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ilaria Rebay / Tony Weil / Andrew D. Sharrocks
Evaluated 8 Sep 2006

Roles of sumoylation of a reptin chromatin-remodelling complex in cancer metastasis.
Kim JH, Choi HJ, …, Chung CH, Baek SH
Nat Cell Biol 2006 Jun 8(6):631-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Andrew D. Sharrocks
Evaluated 15 Aug 2006

A positive feedback loop couples Ras activation and CD44 alternative splicing.
Cheng C, Yaffe MB, Sharp PA
Genes Dev 2006 Jul 1 20(13):1715-20 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Andrew D. Sharrocks
Evaluated 1 Aug 2006

The Evf-2 noncoding RNA is transcribed from the Dlx-5/6 ultraconserved region and functions as a Dlx-2 transcriptional coactivator.
Feng J, Bi C, …, Shah P, Kohtz JD
Genes Dev 2006 Jun 1 20(11):1470-84 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Andrew D. Sharrocks
Evaluated 19 Jun 2006

Systems biology approaches identify ATF3 as a negative regulator of Toll-like receptor 4.
Gilchrist M, Thorsson V, …, Bolouri H, Aderem A
Nature 2006 May 11 441(7090):173-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Raymond Mejia / Andrew D. Sharrocks / David Underhill / Ruth Roberts
Evaluated 31 May 2006

A loss-of-function RNA interference screen for molecular targets in cancer.
Ngo VN, Davis RE, …, Powell J, Staudt LM
Nature 2006 May 4 441(7089):106-10 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Astar Winoto / William Kaelin / Giulio Superti-Furga / Andrew D. Sharrocks
Evaluated 16 May 2006

PIAS1 confers DNA-binding specificity on the Msx1 homeoprotein.
Lee H, Quinn JC, …, Spector DL, Abate-Shen C
Genes Dev 2006 Apr 1 20(7):784-94 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Andrew D. Sharrocks
Evaluated 16 May 2006

A minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C/EBPalpha regulates human granulopoiesis.
Fazi F, Rosa A, …, Nervi C, Bozzoni I
Cell 2005 Dec 2 123(5):819-31 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Bino John / Andrew D. Sharrocks
Evaluated 11 Apr 2006

The role of docking interactions in mediating signaling input, output, and discrimination in the yeast MAPK network.
Reményi A, Good MC, Bhattacharyya RP, Lim WA
Mol Cell 2005 Dec 22 20(6):951-62 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Andrew D. Sharrocks
Evaluated 21 Mar 2006

A calcium-regulated MEF2 sumoylation switch controls postsynaptic differentiation.
Shalizi A, Gaudillière B, …, Harper JW, Bonni A
Science 2006 Feb 17 311(5763):1012-7 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Andrew D. Sharrocks
Evaluated 21 Mar 2006

Histone H3 tail positioning and acetylation by the c-Myb but not the v-Myb DNA-binding SANT domain.
Mo X, Kowenz-Leutz E, …, Xu H, Leutz A
Genes Dev 2005 Oct 15 19(20):2447-57 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Andrew D. Sharrocks
Evaluated 20 Jan 2006

The APC/C and CBP/p300 cooperate to regulate transcription and cell-cycle progression.
Turnell AS, Stewart GS, …, Elledge SJ, Gallimore PH
Nature 2005 Dec 1 438(7068):690-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Andrew D. Sharrocks
Evaluated 19 Dec 2005

SoxE factors function equivalently during neural crest and inner ear development and their activity is regulated by SUMOylation.
Taylor KM, Labonne C
Dev Cell 2005 Nov 9(5):593-603 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Andrew D. Sharrocks
Evaluated 19 Dec 2005

A putative stimulatory role for activator turnover in gene expression.
Lipford JR, Smith GT, Chi Y, Deshaies RJ
Nature 2005 Nov 3 438(7064):113-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Andrew D. Sharrocks
Evaluated 11 Nov 2005

Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1.
Carroll JS, Liu XS, …, Silver PA, Brown M
Cell 2005 Jul 15 122(1):33-43 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Michael Weber / Andrew D. Sharrocks
Evaluated 11 Oct 2005

A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma.
Pascual G, Fong AL, …, Rosenfeld MG, Glass CK
Nature 2005 Sep 29 437(7059):759-63 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Curt Sigmund / Andrew D. Sharrocks / Michael Gold / Cheng-Ming Chiang
Evaluated 11 Oct 2005

Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development.
Nateri AS, Spencer-Dene B, Behrens A
Nature 2005 Sep 8 437(7056):281-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Andrew D. Sharrocks
Evaluated 19 Sep 2005

Circadian clock control by SUMOylation of BMAL1.
Cardone L, Hirayama J, …, Palvimo JJ, Sassone-Corsi P
Science 2005 Aug 26 309(5739):1390-4 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Andrew D. Sharrocks
Evaluated 19 Sep 2005

Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis.
Zhao Y, Samal E, Srivastava D
Nature 2005 Jul 14 436(7048):214-20 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Chaya Kalcheim / John Kyriakis / Andrew D. Sharrocks
Evaluated 27 Jul 2005

Histone acetyltransferase activity of p300 is required for transcriptional repression by the promyelocytic leukemia zinc finger protein.
Guidez F, Howell L, …, Licht J, Zelent A
Mol Cell Biol 2005 Jul 25(13):5552-66 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Andrew D. Sharrocks
Evaluated 21 Jul 2005

Targeting fusion protein/corepressor contact restores differentiation response in leukemia cells.
Racanicchi S, Maccherani C, …, Nervi C, Grignani F
EMBO J 2005 Mar 23 24(6):1232-42 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Andrew D. Sharrocks
Evaluated 21 Jun 2005

A microRNA polycistron as a potential human oncogene.
He L, Thomson JM, …, Hannon GJ, Hammond SM
Nature 2005 Jun 9 435(7043):828-33 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Andrew D. Sharrocks / Warren Pear / Miles Wilkinson / David Bilder / Ulf Pettersson
Evaluated 21 Jun 2005

p38 MAP kinase inhibition enables proliferation of adult mammalian cardiomyocytes.
Engel FB, Schebesta M, …, Wang Y, Keating MT
Genes Dev 2005 May 15 19(10):1175-87 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Andrew D. Sharrocks
Evaluated 27 May 2005

An initial blueprint for myogenic differentiation.
Blais A, Tsikitis M, …, Kluger Y, Dynlacht BD
Genes Dev 2005 Mar 1 19(5):553-69 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Andrew D. Sharrocks
Evaluated 3 May 2005

SUMO modification of the ubiquitin-conjugating enzyme E2-25K.
Pichler A, Knipscheer P, …, Melchior F, Sixma TK
Nat Struct Mol Biol 2005 Mar 12(3):264-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Mary Dasso / Andrew D. Sharrocks
Evaluated 3 May 2005

Identification of small-molecule antagonists that inhibit an activator: coactivator interaction.
Best JL, Amezcua CA, …, Gardner KH, Montminy M
Proc Natl Acad Sci U S A 2004 Dec 21 101(51):17622-7 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Andrew D. Sharrocks
Evaluated 2 Mar 2005

Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs.
Lim LP, Lau NC, …, Linsley PS, Johnson JM
Nature 2005 Feb 17 433(7027):769-73 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Isaac Kohane / Harukazu Nakamura / Fritz Eckstein / Ulf Pettersson / Andrew D. Sharrocks / Detlef Weigel / Richard Carthew / Alejandro Sanchez-Alvarado / Vishvanath Nene / Miles Wilkinson
Evaluated 2 Mar 2005

Defining the CREB regulon: a genome-wide analysis of transcription factor regulatory regions.
Impey S, McCorkle SR, …, Mandel G, Goodman RH
Cell 2004 Dec 29 119(7):1041-54 [abstract on PubMed] [related articles] [