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Paul Clarke
Biomedical Research Centre, University of Dundee, Dundee, United Kingdom

Faculty Member: CELL BIOLOGY > Cell growth & division [ since 31 January 2007 ]
[ Biography ] [ Homepage ] [ Evaluations ]
Biography

Contact:
Professor Paul R. Clarke,
College of Medicine Dentistry and Nursing,
University of Dundee,
Ninewells Hospital and Medical School,
Dundee DD1 9SY,
Scotland, UK.
Tel +44 (0) 1382 425580;
+44 (0) 1382 496669 (assistant);
Fax +44 (0) 1382 669993;
e-mail p.r.clarke@dundee.ac.uk.

Biography:
2005 Personal Chair in Cancer Cell Biology, University of Dundee.
2005-2009 Royal Society-Wolfson Research Merit Award.
2003-2005 Reader, Biomedical Research Centre, University of Dundee.
1999-2005 Cancer Research UK Senior Research Fellow.
1998-2003 Senior Lecturer, Biomedical Research Centre, University of Dundee.
1994-1998 Zeneca Senior Research Fellow and Honorary Lecturer, School of
Biological Sciences, University of Manchester.
1991-1994 Wellcome Trust and EMBL Research Fellow, Karsenti Group, Cell
Biology Programme, European Molecular Biology Laboratory,
Heidelberg.
1986-1990 Ph.D. Student, Dept. of Biochemistry, University of Dundee.
Supervisor: Professor D. Grahame Hardie, FRS, FRSE.
1983-1986 Undergraduate, Dept. of Biochemistry, University of Bristol.

Research interests:
Regulation of the cell division cycle and apoptosis in three areas: 1) regulation of Ran GTPase and its roles during the cell cycle, 2) cell cycle checkpoints, and 3) control of the intrinsic apoptotic pathway. Post-translational mechanisms of regulation, in particular protein phosphorylation.

Home page

http://www.dundee.ac.uk/biomedres/clarke.htm

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Evaluations

Kid-mediated chromosome compaction ensures proper nuclear envelope formation.
Ohsugi M, Adachi K, …, Iwakura Y, Yamamoto T
Cell 2008 Mar 7 132(5):771-82 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Paul Clarke / Andy Golden
Evaluated 27 May 2008

Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha.
Dawlaty MM, Malureanu L, …, Grosschedl R, van Deursen JM
Cell 2008 Apr 4 133(1):103-15 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Wotton / Paul Clarke / Titia Sixma
Evaluated 25 Apr 2008

Mammalian Cells Change Volume during Mitosis.
Boucrot E, Kirchhausen T
PLoS ONE 2008 3:e1477 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Paul Clarke
Evaluated 29 Feb 2008

The molecular architecture of the nuclear pore complex.
Alber F, Dokudovskaya S, …, Sali A, Rout MP
Nature 2007 Nov 29 450(7170):695-701 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Petra Fromme / Tom Misteli / Paul Clarke
Evaluated 21 Dec 2007

Nuclear size control in fission yeast.
Neumann FR, Nurse P
J Cell Biol 2007 179:593-600 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Paul Clarke / Nick Rhind / Mohan Balasubramanian
Evaluated 20 Nov 2007

Cdk1 is sufficient to drive the mammalian cell cycle.
Santamaría D, Barrière C, …, Malumbres M, Barbacid M
Nature 2007 Aug 16 448(7155):811-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Paul Clarke / Nick Rhind
Evaluated 30 Oct 2007

N-terminal alpha-methylation of RCC1 is necessary for stable chromatin association and normal mitosis.
Chen T, Muratore TL, …, Hunt DF, Macara IG
Nat Cell Biol 2007 May 9(5):596-603 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Paul Clarke
Evaluated 30 Aug 2007

The Spindle Pole Bodies Facilitate Nuclear Envelope Division during Closed Mitosis in Fission Yeast.
Zheng L, Schwartz C, …, Khodjakov A, Oliferenko S
PLoS Biol 2007 Jun 19 5(7):e170 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Paul Clarke
Evaluated 11 Jul 2007

Alp7/TACC is a crucial target in Ran-GTPase-dependent spindle formation in fission yeast.
Sato M, Toda T
Nature 2007 May 17 447(7142):334-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Paul Clarke
Evaluated 29 Jun 2007

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