Graduated from University of Oxford, UK, in 1981 (BA in Chemistry) and the University of York, UK, in 1986 (D.Phil. Crystallography) with Guy Dodson. Post-doctoral fellow with Stephen Harrison at Harvard University 1987-1990. Assistant Professor at Dana-Farber Cancer Institute/Harvard Medical School 1990-1995. Professor, Chair of Crystallography, University of Leicester, UK 1995-1999. Professor, Director of Program on Cell Adhesion, The Burnham Institute, La Jolla, CA 1999-present.

The structure of alpha -parvin CH2/paxillin LD1 complex reveals a novel modular recognition for focal adhesion assembly. Wang X, Fukuda K, …, Gronenborn A, Qin J J Biol Chem 2008 May 28 [abstract on PubMed] [related articles] [FREE full text] Selected by | Robert Liddington Evaluated 10 Jun 2008 Differences in Regulation of Drosophila and Vertebrate Integrin Affinity by Talin. Helsten TL, Bunch TA, …, Brower DL, Shattil SJ Mol Biol Cell 2008 May 28 [abstract on PubMed] [related articles] [FREE full text] Selected by | Robert Liddington Evaluated 9 Jun 2008 Cooperative role of the membrane-proximal and distal residues of the integrin beta 3 cytoplasmic domain in regulation of talin-mediated alpha IIbbeta 3 activation. Hato T, Yamanouchi J, …, Sakai I, Yasukawa M J Biol Chem 2008 Jan 2 [abstract on PubMed] [related articles] [FREE full text] Selected by | Robert Liddington Evaluated 30 Jan 2008 The vinculin binding sites of talin and alpha-actinin are sufficient to activate vinculin. Bois PR, O'Hara BP, …, Kirkpatrick J, Izard T J Biol Chem 2006 Mar 17 281(11):7228-36 [abstract on PubMed] [related articles] [FREE full text] Selected by | Marie-France Carlier Dissenters | Robert Liddington Evaluated 1 Aug 2006 A conformational switch in vinculin drives formation and dynamics of a talin-vinculin complex at focal adhesions. Cohen DM, Kutscher B, …, Murphy DB, Craig SW J Biol Chem 2006 Jun 9 281(23):16006-15 [abstract on PubMed] [related articles] [FREE full text] Selected by | Robert Liddington Evaluated 13 Jul 2006 Transmembrane domain helix packing stabilizes integrin alphaIIbbeta3 in the low affinity state. Partridge AW, Liu S, …, Bowie JU, Ginsberg MH J Biol Chem 2005 Feb 25 280(8):7294-300 [abstract on PubMed] [related articles] [FREE full text] Selected by | Martin Humphries / Robert Liddington Evaluated 21 Feb 2005 Tyrosine phosphorylation of beta3 integrin provides a binding site for Pyk2. Butler B, Blystone SD J Biol Chem 2005 Apr 15 280(15):14556-62 [abstract on PubMed] [related articles] [FREE full text] Selected by | Robert Liddington Evaluated 21 Feb 2005 Intersubunit signal transmission in integrins by a receptor-like interaction with a pull spring. Yang W, Shimaoka M, …, Takagi J, Springer TA Proc Natl Acad Sci U S A 2004 Mar 2 101(9):2906-11 [abstract on PubMed] [related articles] [FREE full text] Selected by | Robert Liddington Evaluated 17 Mar 2004 Locking the beta3 integrin I-like domain into high and low affinity conformations with disulfides. Luo BH, Takagi J, Springer TA J Biol Chem 2004 Mar 12 279(11):10215-21 [abstract on PubMed] [related articles] [FREE full text] Selected by | Robert Liddington / Mark Ginsberg Evaluated 2 Feb 2004 Vinculin activation by talin through helical bundle conversion. Izard T, Evans G, …, Bricogne G, Bois PR Nature 2004 Jan 8 427(6970):171-5 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Robert Liddington Evaluated 30 Jan 2004 Global conformational rearrangements in integrin extracellular domains in outside-in and inside-out signaling. Takagi J, Petre BM, Walz T, Springer TA Cell 2002 Sep 6 110(5):599-11 [abstract on PubMed] [related articles] [order article] Selected by | Martin Humphries / Robert Liddington / Fiona Watt / David Stokes Evaluated 25 Sep 2002 A structural mechanism of integrin alpha(IIb)beta(3) "inside-out" activation as regulated by its cytoplasmic face. Vinogradova O, Velyvis A, …, Plow E, Qin J Cell 2002 Sep 6 110(5):587-97 [abstract on PubMed] [related articles] [order article] Selected by | Martin Humphries / Robert Liddington / Fiona Watt Evaluated 24 Sep 2002 Bacterial adhesion to target cells enhanced by shear force. Thomas WE, Trintchina E, …, Vogel V, Sokurenko EV Cell 2002 Jun 28 109(7):913-23 [abstract on PubMed] [related articles] [order article] Selected by | Esther Bullitt / Michael Dustin / Robert Liddington Evaluated 14 Aug 2002 Transmembrane signal transduction of the alpha(IIb)beta(3) integrin. Gottschalk KE, Adams PD, Brunger AT, Kessler H Protein Sci 2002 Jul 11(7):1800-12 [abstract on PubMed] [related articles] [FREE full text] Selected by | Robert Liddington Evaluated 14 Aug 2002 Structure of the carboxyl-terminal Src kinase, Csk. Ogawa A, Takayama Y, …, Okada M, Tsukihara T J Biol Chem 2002 Apr 26 277(17):14351-4 [abstract on PubMed] [related articles] [FREE full text] Selected by | Robert Liddington Evaluated 1 Jul 2002 Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation. Beglova N, Blacklow SC, Takagi J, Springer TA Nat Struct Biol 2002 Apr 9(4):282-7 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Kristina Downing / Martin Humphries / Robert Liddington / H Jane Dyson Evaluated 25 Apr 2002 C-cadherin ectodomain structure and implications for cell adhesion mechanisms. Boggon TJ, Murray J, …, Gumbiner BM, Shapiro L Science 2002 May 17 296(5571):1308-13 [abstract on PubMed] [related articles] [FREE full text] Selected by | Robert Liddington / Vance Lemmon / Carlos Ibanez / Charles Streuli / Jia-huai Wang / David Stokes Evaluated 24 Apr 2002 Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand. Xiong JP, Stehle T, …, Goodman SL, Arnaout MA Science 2002 Apr 5 296(5565):151-5 [abstract on PubMed] [related articles] [FREE full text] Selected by | John Couchman / Robert Liddington / Vance Lemmon / Alfred Wittinghofer / Martin Humphries Evaluated 24 Apr 2002 Structural basis for autoinhibition of the Ephb2 receptor tyrosine kinase by the unphosphorylated juxtamembrane region. Wybenga-Groot LE, Baskin B, …, Pawson T, Sicheri F Cell 2001 Sep 21 106(6):745-57 [abstract on PubMed] [related articles] [order article] Selected by | Michael Greenberg / Robert Liddington / Michael Schaller / Stevan Hubbard Evaluated 22 Oct 2001 Prokaryotic origin of the actin cytoskeleton. van den Ent F, Amos LA, Löwe J Nature 2001 Sep 6 413(6851):39-44 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Eva Nogales / Ford Doolittle / Keiichi Namba / Robert Liddington / Tony Crowther / Piet de Boer / Norma Andrews / Amy McGough / Tracy Palmer Evaluated 22 Oct 2001

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