Type III secretion systems (T3SS) are widely distributed, essential virulence determinants of Gram-negative bacteria. T3SS serve to translocate, upon contact with eukaryotic host cells, proteins effectors of virulence from the bacterial cytoplasm into the host cytoplasm. Our laboratory studies the function and structure of the T3SS of Shigella flexeri, the agent of bacillary dysentery, using a variety of cell biological, biochemical, genetic and structural approaches. We specifically focus on the energising ATPase, the needle and the translocation pore of the T3SS system, as well as on the function of some putative but still uncharacterised secreted effectors within host cells.

http://users.path.ox.ac.uk/~ablocker/

Coxsackie B4 virus infection of beta cells and natural killer cell insulitis in recent-onset type 1 diabetic patients. Dotta F, Censini S, …, Roep BO, Marchetti P Proc Natl Acad Sci U S A 2007 Mar 20 104(12):5115-20 [abstract on PubMed] [related articles] [FREE full text] Selected by | Mark Atkinson / Ariel Blocker Evaluated 3 Apr 2007 Vaccinia virus-induced cell motility requires F11L-mediated inhibition of RhoA signaling. Valderrama F, Cordeiro JV, …, Frischknecht F, Way M Science 2006 Jan 20 311(5759):377-81 [abstract on PubMed] [related articles] [FREE full text] Selected by | Ariel Blocker Evaluated 20 Dec 2006 Salmonella typhimurium disseminates within its host by manipulating the motility of infected cells. Worley MJ, Nieman GS, Geddes K, Heffron F Proc Natl Acad Sci U S A 2006 Nov 21 103(47):17915-20 [abstract on PubMed] [related articles] [FREE full text] Selected by | Francisco Garcia-del Portillo / James Bliska / Ariel Blocker Evaluated 20 Dec 2006 Chlamydial TARP is a bacterial nucleator of actin. Jewett TJ, Fischer ER, Mead DJ, Hackstadt T Proc Natl Acad Sci U S A 2006 Oct 17 103(42):15599-604 [abstract on PubMed] [related articles] [FREE full text] Selected by | Ariel Blocker / Matthew Welch Evaluated 1 Nov 2006 Histamine signaling through the H(2) receptor in the Peyer's patch is important for controlling Yersinia enterocolitica infection. Handley SA, Dube PH, Miller VL Proc Natl Acad Sci U S A 2006 Jun 13 103(24):9268-73 [abstract on PubMed] [related articles] [FREE full text] Selected by | Ariel Blocker / Ralph Isberg Evaluated 16 Jun 2006 Switch interactions control energy frustration and multiple flagellar filament structures. Kitao A, Yonekura K, …, Namba K, Go N Proc Natl Acad Sci U S A 2006 Mar 28 103(13):4894-9 [abstract on PubMed] [related articles] [FREE full text] Selected by | Ariel Blocker Evaluated 10 May 2006 Immuno-electron tomography of ER exit sites reveals the existence of free COPII-coated transport carriers. Zeuschner D, Geerts WJ, …, Koster AJ, Klumperman J Nat Cell Biol 2006 Apr 8(4):377-83 [abstract on PubMed] [related articles] [full text] [order article] Selected by | David Stephens / Jesse Hay / Ariel Blocker Evaluated 12 Apr 2006 A pneumococcal pilus influences virulence and host inflammatory responses. Barocchi MA, Ries J, …, Rappuoli R, Henriques-Normark B Proc Natl Acad Sci U S A 2006 Feb 21 103(8):2857-62 [abstract on PubMed] [related articles] [FREE full text] Selected by | Ariel Blocker Evaluated 2 Mar 2006 Magnetic resonance imaging of Klebsiella pneumoniae-induced pneumonia in mice. Tournebize R, Doan BT, …, Beloeil JC, Sansonetti PJ Cell Microbiol 2006 Jan 8(1):33-43 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Ariel Blocker Evaluated 17 Jan 2006 Identification of a bacterial type III effector family with G protein mimicry functions. Alto NM, Shao F, …, Boone C, Dixon JE Cell 2006 Jan 13 124(1):133-45 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Sachdev Sidhu / Ariel Blocker / Ilan Rosenshine / Guy Tran Van Nhieu / Christoph Dehio / Michael Gold / Drusilla Burns / Pascale Cossart / Channing Der / Victor Nizet / Alfred Wittinghofer Evaluated 13 Jan 2006 The V-antigen of Yersinia forms a distinct structure at the tip of injectisome needles. Mueller CA, Broz P, …, Engel A, Cornelis GR Science 2005 Oct 28 310(5748):674-6 [abstract on PubMed] [related articles] [FREE full text] Selected by | Ariel Blocker / Rino Rappuoli Evaluated 7 Nov 2005

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