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Carol Otey
University of North Carolina at Chapel Hill, United States of America

Faculty Member: CELL BIOLOGY > Cell adhesion [ since 4 July 2001 ]
[ Sponsorship ] [ Evaluations ]
Sponsorship

Carol Otey sponsors free access to F1000 for University of Colombo, Sri Lanka. Supporting F1000's initiative to make itself available to scientists in all countries, including free access to developing countries (more details).

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Evaluations

Endogenous RhoG is dispensable for integrin-mediated cell spreading but contributes to Rac-independent migration.
Meller J, Vidali L, Schwartz MA
J Cell Sci 2008 Jun 15 121(Pt 12):1981-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Carol Otey / Ed Manser
Evaluated 13 Jun 2008

PGE2-mediated podosome loss in dendritic cells is dependent on actomyosin contraction downstream of the RhoA-Rho-kinase axis.
van Helden SF, Oud MM, …, Figdor CG, van Leeuwen FN
J Cell Sci 2008 Apr 1 121(Pt 7):1096-106 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Carol Otey
Evaluated 31 Mar 2008

Dynamic analysis of filopodial interactions during the zippering phase of Drosophila dorsal closure.
Millard TH, Martin P
Development 2008 Feb 135(4):621-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Mary Baylies / Carol Otey
Evaluated 19 Mar 2008

Myofibroblast contraction activates latent TGF-beta1 from the extracellular matrix.
Wipff PJ, Rifkin DB, Meister JJ, Hinz B
J Cell Biol 2007 Dec 17 179:1311-23 [abstract on PubMed] [related articles] [order article]
Selected by | Giulio Gabbiani / Carol Otey
Evaluated 17 Jan 2008


Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells.
Gaggioli C, Hooper S, …, Harrington K, Sahai E
Nat Cell Biol 2007 Dec 9(12):1392-400 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Martin A. Schwartz / Filippo Giancotti / Carol Otey / Frank de Gruijl / C. Michael DiPersio / Anna Huttenlocher / Kathleen J. Green
Evaluated 19 Dec 2007

Lasp-2 expression, localization, and ligand interactions: a new Z-disc scaffolding protein.
Zieseniss A, Terasaki AG, Gregorio CC
Cell Motil Cytoskeleton 2008 Jan 65(1):59-72 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Carol Otey
Evaluated 19 Dec 2007

Loss of ACTN3 gene function alters mouse muscle metabolism and shows evidence of positive selection in humans.
MacArthur DG, Seto JT, …, Yang N, North KN
Nat Genet 2007 Oct 39(10):1261-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Carol Otey
Evaluated 1 Nov 2007

Alpha-actinin is required for tightly regulated remodeling of the actin cortical network during cytokinesis.
Mukhina S, Wang YL, Murata-Hori M
Dev Cell 2007 Oct 13(4):554-65 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Carol Otey
Evaluated 23 Oct 2007

Profilin2 contributes to synaptic vesicle exocytosis, neuronal excitability, and novelty-seeking behavior.
Pilo Boyl P, Di Nardo A, …, Giustetto M, Witke W
EMBO J 2007 Jun 20 26(12):2991-3002 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Carol Otey
Evaluated 20 Aug 2007

Transcellular diapedesis is initiated by invasive podosomes.
Carman CV, Sage PT, …, Dvorak AM, Springer TA
Immunity 2007 Jun 26(6):784-97 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Carol Otey / William A Muller / Paul Martin
Evaluated 19 Jul 2007

Ena/VASP function in retinal axons is required for terminal arborization but not pathway navigation.
Dwivedy A, Gertler FB, …, Holt CE, Lebrand C
Development 2007 Jun 134(11):2137-46 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Carol Otey
Evaluated 30 May 2007

Syndecan-4-dependent Rac1 regulation determines directional migration in response to the extracellular matrix.
Bass MD, Roach KA, …, Spatz JP, Humphries MJ
J Cell Biol 2007 May 7 177(3):527-38 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Kenneth Yamada / Carol Otey
Evaluated 11 May 2007

Missing-in-metastasis and IRSp53 deform PI(4,5)P2-rich membranes by an inverse BAR domain-like mechanism.
Mattila PK, Pykäläinen A, …, Jokitalo E, Lappalainen P
J Cell Biol 2007 Mar 26 176(7):953-64 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Kenneth Yamada / Peter McPherson / Carol Otey
Evaluated 10 May 2007

Retroviruses can establish filopodial bridges for efficient cell-to-cell transmission.
Sherer NM, Lehmann MJ, …, Pypaert M, Mothes W
Nat Cell Biol 2007 Mar 9(3):310-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Axel Nohturfft / Carol Otey
Evaluated 28 Mar 2007

Tricellulin is a tight-junction protein necessary for hearing.
Riazuddin S, Ahmed ZM, …, Riazuddin S, Friedman TB
Am J Hum Genet 2006 Dec 79(6):1040-51 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Carol Otey
Evaluated 19 Feb 2007

Regulation of cell shape by Cdc42 is mediated by the synergic actin-bundling activity of the Eps8-IRSp53 complex.
Disanza A, Mantoani S, …, Stradal TE, Scita G
Nat Cell Biol 2006 Dec 8(12):1337-47 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Carol Otey
Evaluated 31 Jan 2007

Matrix elasticity directs stem cell lineage specification.
Engler AJ, Sen S, Sweeney HL, Discher DE
Cell 2006 Aug 25 126(4):677-89 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Kenneth Yamada / Ray Rodgers / Carol Otey / Paul Bornstein / Avri Ben-Ze'ev / Michel Labouesse / Thomas Egelhoff / Deborah Andrew / Amy Wagers
Evaluated 5 Sep 2006


Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury.
Okada S, Nakamura M, …, Toyama Y, Okano H
Nat Med 2006 Jul 12(7):829-34 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Carol Otey
Evaluated 18 Jul 2006

The bundling activity of vasodilator-stimulated phosphoprotein is required for filopodium formation.
Schirenbeck A, Arasada R, …, Schleicher M, Faix J
Proc Natl Acad Sci U S A 2006 May 16 103(20):7694-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Pekka Lappalainen / Carol Otey / Richard Gomer
Evaluated 26 May 2006

Targeted wild-type and jerker espins reveal a novel, WH2-domain-dependent way to make actin bundles in cells.
Loomis PA, Kelly AE, …, Mullins RD, Bartles JR
J Cell Sci 2006 Apr 15 119(Pt 8):1655-65 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Carol Otey
Evaluated 24 Apr 2006

Extracellular matrix metalloproteinase inducer (CD147) confers resistance of breast cancer cells to Anoikis through inhibition of Bim.
Yang JM, O'Neill P, …, Yan L, Hait WN
J Biol Chem 2006 Apr 7 281(14):9719-27 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Carol Otey
Evaluated 3 Apr 2006

Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells.
Ikenouchi J, Furuse M, …, Tsukita S, Tsukita S
J Cell Biol 2005 Dec 19 171(6):939-45 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Alan Fanning / Carol Otey
Evaluated 6 Feb 2006

Alpha4beta1-dependent adhesion strengthening under mechanical strain is regulated by paxillin association with the alpha4-cytoplasmic domain.
Alon R, Feigelson SW, …, Benoit M, Ginsberg MH
J Cell Biol 2005 Dec 19 171(6):1073-84 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Carol Otey
Evaluated 6 Jan 2006

Shroom regulates epithelial cell shape via the apical positioning of an actomyosin network.
Hildebrand JD
J Cell Sci 2005 Nov 15 118(Pt 22):5191-203 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Michel Labouesse / Carol Otey / Thomas Lecuit
Evaluated 17 Nov 2005

A microtubule-binding Rho-GEF controls cell morphology during convergent extension of Xenopus laevis.
Kwan KM, Kirschner MW
Development 2005 Oct 132(20):4599-610 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Carol Otey
Evaluated 13 Oct 2005

CLAMP, a novel microtubule-associated protein with EB-type calponin homology.
Dougherty GW, Adler HJ, …, Merritt RC, Kachar B
Cell Motil Cytoskeleton 2005 Nov 62(3):141-56 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Carol Otey
Evaluated 7 Oct 2005

Description and characterization of a chamber for viewing and quantifying cancer cell chemotaxis.
Soon L, Mouneimne G, …, Wyckoff J, Condeelis J
Cell Motil Cytoskeleton 2005 Sep 62(1):27-34 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Carol Otey
Evaluated 23 Aug 2005

Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo.
Nimmerjahn A, Kirchhoff F, Helmchen F
Science 2005 May 27 308(5726):1314-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Vance Lemmon / Robert Sapolsky / George Yap / Carol Otey
Evaluated 21 Jul 2005

Vinculin acts as a sensor in lipid regulation of adhesion-site turnover.
Chandrasekar I, Stradal TE, …, Jockusch BM, Ziegler WH
J Cell Sci 2005 Apr 1 118(Pt 7):1461-72 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Carol Otey
Evaluated 14 Apr 2005

Actin-filament cross-linking protein T-plastin increases Arp2/3-mediated actin-based movement.
Giganti A, Plastino J, …, Sykes C, Friederich E
J Cell Sci 2005 Mar 15 118(Pt 6):1255-65 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Carol Otey
Evaluated 24 Mar 2005

Slipping or gripping? Fluorescent speckle microscopy in fish keratocytes reveals two different mechanisms for generating a retrograde flow of actin.
Jurado C, Haserick JR, Lee J
Mol Biol Cell 2005 Feb 16(2):507-18 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Carol Otey
Evaluated 2 Mar 2005

Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion.
Yeung T, Georges PC, …, Weaver V, Janmey PA
Cell Motil Cytoskeleton 2005 Jan 60(1):24-34 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Carol Otey
Evaluated 10 Jan 2005

Multiple rows of cells behind an epithelial wound edge extend cryptic lamellipodia to collectively drive cell-sheet movement.
Farooqui R, Fenteany G
J Cell Sci 2005 Jan 1 118(Pt 1):51-63 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Carol Otey / William Bement
Evaluated 10 Jan 2005

In vivo evidence for short- and long-range cell communication in cranial neural crest cells.
Teddy JM, Kulesa PM
Development 2004 Dec 131(24):6141-51 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Harukazu Nakamura / Yu-Li Wang / Carol Otey
Evaluated 7 Dec 2004

Spermidine/spermine N1-acetyltransferase specifically binds to the integrin alpha9 subunit cytoplasmic domain and enhances cell migration.
Chen C, Young BA, …, Pegg AE, Sheppard D
J Cell Biol 2004 Oct 11 167(1):161-70 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Carol Otey
Evaluated 15 Nov 2004

Protocadherin FAT1 binds Ena/VASP proteins and is necessary for actin dynamics and cell polarization.
Moeller MJ, Soofi A, …, Kriz W, Holzman LB
EMBO J 2004 Oct 1 23(19):3769-79 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Carol Otey
Evaluated 9 Sep 2004

NG2 proteoglycan promotes endothelial cell motility and angiogenesis via engagement of galectin-3 and alpha3beta1 integrin.
Fukushi J, Makagiansar IT, Stallcup WB
Mol Biol Cell 2004 Aug 15(8):3580-90 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Carol Otey
Evaluated 2 Aug 2004

Arp2/3 is a negative regulator of growth cone translocation.
Strasser GA, Rahim NA, …, Gertler FB, Lanier LM
Neuron 2004 Jul 8 43(1):81-94 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Carol Otey / Paul Kulesa
Evaluated 30 Jul 2004

Involvement of LMO7 in the association of two cell-cell adhesion molecules, nectin and E-cadherin, through afadin and alpha-actinin in epithelial cells.
Ooshio T, Irie K, …, Imai T, Takai Y
J Biol Chem 2004 Jul 23 279(30):31365-73 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Carol Otey
Evaluated 22 Jul 2004

Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment.
McBeath R, Pirone DM, …, Bhadriraju K, Chen CS
Dev Cell 2004 Apr 6(4):483-95 [abstract on PubMed] [related articles] [order article]
Selected by | Valeri Vasioukhin / Erez Raz / Christopher Marshall / Carol Otey
Evaluated 14 Jun 2004

Affixin interacts with alpha-actinin and mediates integrin signaling for reorganization of F-actin induced by initial cell-substrate interaction.
Yamaji S, Suzuki A, …, Ohno S, Ishigatsubo Y
J Cell Biol 2004 May 24 165(4):539-51 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Carol Otey
Evaluated 14 Jun 2004

Tumor cell alpha3beta1 integrin and vascular laminin-5 mediate pulmonary arrest and metastasis.
Wang H, Fu W, …, Al-Mehdi A, Muschel RJ
J Cell Biol 2004 Mar 15 164(6):935-41 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Carol Otey
Evaluated 26 Mar 2004

Cortactin is necessary for E-cadherin-mediated contact formation and actin reorganization.
Helwani FM, Kovacs EM, …, Weed SA, Yap AS
J Cell Biol 2004 Mar 15 164(6):899-910 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Carol Otey / Kathleen J. Green
Evaluated 24 Mar 2004

Chemical-genetic inhibition of a sensitized mutant myosin Vb demonstrates a role in peripheral-pericentriolar membrane traffic.
Provance DW, Gourley CR, …, Gillespie PG, Mercer JA
Proc Natl Acad Sci U S A 2004 Feb 17 101(7):1868-73 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Carol Otey / John Kendrick-Jones
Evaluated 27 Feb 2004

Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells.
Scacheri PC, Rozenblatt-Rosen O, …, Meyerson M, Collins FS
Proc Natl Acad Sci U S A 2004 Feb 17 101(7):1892-7 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Fritz Eckstein / Carol Otey
Evaluated 26 Feb 2004

Cell behaviour on micropatterned substrata: limits of extracellular matrix geometry for spreading and adhesion.
Lehnert D, Wehrle-Haller B, …, Imhof BA, Bastmeyer M
J Cell Sci 2004 Jan 1 117(Pt 1):41-52 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Carol Otey
Evaluated 23 Jan 2004

The cellular prion protein PrPc is expressed in human enterocytes in cell-cell junctional domains.
Morel E, Fouquet S, …, Pillot T, Rousset M
J Biol Chem 2004 Jan 9 279(2):1499-505 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Carol Otey
Evaluated 22 Jan 2004

Actin filament uncapping localizes to ruffling lamellae and rocketing vesicles.
Allen PG
Nat Cell Biol 2003 Nov 5(11):972-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Carol Otey / Klaus Hahn
Evaluated 5 Nov 2003

Enhanced in vivo platelet adhesion in vasodilator-stimulated phosphoprotein (VASP)-deficient mice.
Massberg S, Grüner S, …, Walter U, Gawaz M
Blood 2004 Jan 1 103(1):136-42 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Carol Otey
Evaluated 21 Oct 2003

Complex formation between the postsynaptic scaffolding protein gephyrin, profilin, and Mena: a possible link to the microfilament system.
Giesemann T, Schwarz G, …, Kirsch J, Jockusch BM
J Neurosci 2003 Sep 10 23(23):8330-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Carol Otey
Evaluated 21 Oct 2003

Robust neural integration from retinal transplants in mice deficient in GFAP and vimentin.
Kinouchi R, Takeda M, …, Pekny M, Chen DF
Nat Neurosci 2003 Aug 6(8):863-8 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Carol Otey
Evaluated 21 Aug 2003

Direct, dynamic assessment of cell-matrix interactions inside fibrillar collagen lattices.
Petroll WM, Ma L
Cell Motil Cytoskeleton 2003 Aug 55(4):254-64 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Carol Otey
Evaluated 21 Aug 2003

Colocalization of synapsin and actin during synaptic vesicle recycling.
Bloom O, Evergren E, …, Greengard P, Shupliakov O
J Cell Biol 2003 May 26 161(4):737-47 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Carol Otey
Evaluated 18 Jul 2003

Differential regulation of cell adhesive functions by integrin alpha subunit cytoplasmic tails in vivo.
Na J, Marsden M, DeSimone DW
J Cell Sci 2003 Jun 1 116(Pt 11):2333-43 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Carol Otey
Evaluated 9 Jun 2003

MIM-B, a putative metastasis suppressor protein, binds to actin and to protein tyrosine phosphatase delta.
Woodings JA, Sharp SJ, Machesky LM
Biochem J 2003 Apr 15 371(Pt 2):463-71 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Carol Otey
Evaluated 15 Apr 2003

Migfilin and Mig-2 link focal adhesions to filamin and the actin cytoskeleton and function in cell shape modulation.
Tu Y, Wu S, …, Chen K, Wu C
Cell 2003 Apr 4 113(1):37-47 [abstract on PubMed] [related articles] [order article]
Selected by | Carol Otey / Kenneth Yamada / Martin Humphries
Evaluated 15 Apr 2003

RhoD regulates endosome dynamics through Diaphanous-related Formin and Src tyrosine kinase.
Gasman S, Kalaidzidis Y, Zerial M
Nat Cell Biol 2003 Mar 5(3):195-204 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Robert Parton / Carol Otey
Evaluated 13 Mar 2003

Mouse MIM, a tissue-specific regulator of cytoskeletal dynamics, interacts with ATP-actin monomers through its C-terminal WH2 domain.
Mattila PK, Salminen M, Yamashiro T, Lappalainen P
J Biol Chem 2003 Mar 7 278(10):8452-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Carol Otey
Evaluated 11 Mar 2003

Native Myosin-IXb is a plus-, not a minus-end-directed motor.
O'Connell CB, Mooseker MS
Nat Cell Biol 2003 Feb 5(2):171-2 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Carol Otey / Vladimir I. Gelfand
Evaluated 5 Feb 2003

Requirement of a vasodilator-stimulated phosphoprotein family member for cell adhesion, the formation of filopodia, and chemotaxis in dictyostelium.
Han YH, Chung CY, …, Soll DR, Firtel RA
J Biol Chem 2002 Dec 20 277(51):49877-87 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Carol Otey
Evaluated 7 Jan 2003

Cell migration requires both ion translocation and cytoskeletal anchoring by the Na-H exchanger NHE1.
Denker SP, Barber DL
J Cell Biol 2002 Dec 23 159(6):1087-96 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Alan Rick Horwitz / Carol Otey / Chloe Bulinski
Evaluated 7 Jan 2003

myotilin Mutation found in second pedigree with LGMD1A.
Hauser MA, Conde CB, …, Speer MC, Rosa AL
Am J Hum Genet 2002 Dec 71(6):1428-32 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Carol Otey
Evaluated 9 Dec 2002

Localized suppression of RhoA activity by Tyr31/118-phosphorylated paxillin in cell adhesion and migration.
Tsubouchi A, Sakakura J, …, Yano H, Sabe H
J Cell Biol 2002 Nov 25 159(4):673-83 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Carol Otey / Christopher Turner / Jean Schwarzbauer
Evaluated 9 Dec 2002

Spatial regulation of actin dynamics: a tropomyosin-free, actin-rich compartment at the leading edge.
DesMarais V, Ichetovkin I, Condeelis J, Hitchcock-DeGregori SE
J Cell Sci 2002 Dec 1 115(Pt 23):4649-60 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Carol Otey
Evaluated 21 Nov 2002

The RhoA-binding protein, rhophilin-2, regulates actin cytoskeleton organization.
Peck JW, Oberst M, …, Bowden E, Burbelo PD
J Biol Chem 2002 Nov 15 277(46):43924-32 [abstract on PubMed] [related articles] [FREE full text]