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 | David Sullivan
Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, United States of America | | | Faculty Member: PHARMACOLOGY & DRUG DISCOVERY > Antimicrobial agents [ since 14 August 2006 ] |
| | [ Biography ] [ Evaluations ] | Biography
Department of Molecular Microbiology and Immunology
Johns Hopkins University BloombergSchool Public Health
615 N. Wolfe St. Rm E5628
Baltimore, MD 21205
Telephone: (410) 502-2522
Fax: (410) 955-0105
email: dsulliva@jhsph.edu
Research Interest
My main research interest is malaria, more specifically the molecular biology of metals and how the quinolines interfere with heme iron sequestration into heme crystals called hemozoin. The laboratory is also investigating the Plasmodium biology of copper and zinc. Present and developing work includes new uses for existing drugs with creation of a library of more than 1,800 FDA approved drugs for which we have screened for antimalarial cellular activity. Two additional organismal areas include the pathogenesis of cerebral malaria with a coincubation of P. falciparum with a human brain endothelial model in order to study effects on endothelium and the pathogenesis of mother to child transmission of HIV in the setting of placental malaria. On the population level, the laboratory is investigating new malaria diagnostics based on detection of hemozoin in the blood by laser desorption mass spectrometry and also detection of malaria proteins in the urine. The population dynamics of acquisition of immunity followed by microsatellites in young children in malaria endemic areas is also being explored. My training in adult infectious diseases/internal medicine also has enabled other interactions within the department with HIV and TB researchers as well as teaching in tropical medicine and malaria schoolwide. |
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