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Andrea Sant
Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, United States of America

Faculty Member: IMMUNOLOGY > Antigen processing & recognition [ since 19 November 2002 ]
[ Evaluations ]
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Evaluations

Vaccine adjuvants alter TCR-based selection thresholds.
Malherbe L, Mark L, …, McHeyzer-Williams LJ, McHeyzer-Williams MG
Immunity 2008 May 28(5):698-709 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | David Kranz / Luc Teyton / Marcia Blackman / Andrea Sant
Evaluated 1 Jul 2008

Human CD4+ T cell epitopes from vaccinia virus induced by vaccination or infection.
Calvo-Calle JM, Strug I, …, Baker SP, Stern LJ
PLoS Pathog 2007 Oct 12 3(10):1511-29 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Andrea Sant
Evaluated 18 Mar 2008

Rab27a regulates phagosomal pH and NADPH oxidase recruitment to dendritic cell phagosomes.
Jancic C, Savina A, …, Seabra MC, Amigorena S
Nat Cell Biol 2007 Apr 9(4):367-78 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Andrea Sant
Evaluated 10 Dec 2007

Cutting edge: primary B lymphocytes preferentially expand allogeneic FoxP3+ CD4 T cells.
Chen X, Jensen PE
J Immunol 2007 Aug 15 179(4):2046-50 [abstract on PubMed] [related articles] [order article]
Selected by | Dorothy Yuan / Andrea Sant
Evaluated 27 Sep 2007

Competition for antigen determines the stability of T cell-dendritic cell interactions during clonal expansion.
Garcia Z, Pradelli E, …, Simon A, Bousso P
Proc Natl Acad Sci U S A 2007 Mar 13 104(11):4553-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Reinhold Förster / Andrea Sant
Evaluated 17 Sep 2007

Naive CD4(+) T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude.
Moon JJ, Chu HH, …, Kedl RM, Jenkins MK
Immunity 2007 Aug 27(2):203-13 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Leo Lefrancois / Andrea Sant / David Kranz / Christian Engwerda
Evaluated 10 Sep 2007

Cross-competition of CD8+ T cells shapes the immunodominance hierarchy during boost vaccination.
Kastenmuller W, Gasteiger G, …, Busch DH, Drexler I
J Exp Med 2007 Sep 3 204(9):2187-98 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Andrea Sant
Evaluated 4 Sep 2007

HLA-DM targets the hydrogen bond between the histidine at position beta81 and peptide to dissociate HLA-DR-peptide complexes.
Narayan K, Chou CL, …, Khoruzhenko S, Sadegh-Nasseri S
Nat Immunol 2007 Jan 8(1):92-100 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Andrea Sant
Evaluated 27 Mar 2007

Antigen-experienced T cells limit the priming of naive T cells during infection with Leishmania major.
Gray PM, Reiner SL, …, Kaye PM, Scott P
J Immunol 2006-07-15 177(2):925-33 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Andrea Sant
Evaluated 15 Nov 2006

CD8 T cell competition for dendritic cells in vivo is an early event in activation.
Willis RA, Kappler JW, Marrack PC
Proc Natl Acad Sci U S A 2006 Aug 8 103(32):12063-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Andrea Sant
Evaluated 5 Oct 2006

Human dendritic cell expression of HLA-DO is subset specific and regulated by maturation.
Hornell TM, Burster T, …, Modlin RL, Mellins ED
J Immunol 2006 Mar 15 176(6):3536-47 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Andrea Sant
Evaluated 6 Apr 2006

H2-O expression in primary dendritic cells.
Chen X, Reed-Loisel LM, Karlsson L, Jensen PE
J Immunol 2006 Mar 15 176(6):3548-56 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Andrea Sant
Evaluated 6 Apr 2006

Where CD4+CD25+ T reg cells impinge on autoimmune diabetes.
Chen Z, Herman AE, …, Mathis D, Benoist C
J Exp Med 2005 Nov 21 202(10):1387-97 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Andrea Sant
Evaluated 21 Dec 2005

Dynamics and function of Langerhans cells in vivo: dermal dendritic cells colonize lymph node areas distinct from slower migrating Langerhans cells.
Kissenpfennig A, Henri S, …, Davoust J, Malissen B
Immunity 2005 May 22(5):643-54 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Michael Dustin / Andrea Sant
Evaluated 2 Nov 2005

Activation of bone marrow-resident memory T cells by circulating, antigen-bearing dendritic cells.
Cavanagh LL, Bonasio R, …, Weninger W, von Andrian UH
Nat Immunol 2005 Oct 6(10):1029-37 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Yutaka Tagaya / Andrea Sant
Evaluated 27 Oct 2005

Antigen persistence is required throughout the expansion phase of a CD4(+) T cell response.
Obst R, van Santen HM, Mathis D, Benoist C
J Exp Med 2005 May 16 201(10):1555-65 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Andrea Sant / Allan Zajac / David Margulies
Evaluated 23 May 2005

Structure of an autoimmune T cell receptor complexed with class II peptide-MHC: insights into MHC bias and antigen specificity.
Maynard J, Petersson K, …, Wilson DB, Garcia KC
Immunity 2005 Jan 22(1):81-92 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Kai Wucherpfennig / Andrea Sant
Evaluated 18 Apr 2005

Agonist/endogenous peptide-MHC heterodimers drive T cell activation and sensitivity.
Krogsgaard M, Li QJ, …, Huse M, Davis MM
Nature 2005 Mar 10 434(7030):238-43 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Kai Wucherpfennig / Peter Van Endert / Andrea Sant / Gerald Nepom
Evaluated 15 Apr 2005

Gene dosage--limiting role of Aire in thymic expression, clonal deletion, and organ-specific autoimmunity.
Liston A, Gray DH, …, Peltonen L, Goodnow CC
J Exp Med 2004 Oct 18 200(8):1015-26 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Matthias von Herrath / Torben Lund / Andrea Sant
Evaluated 10 Nov 2004

A hairpin turn in a class II MHC-bound peptide orients residues outside the binding groove for T cell recognition.
Zavala-Ruiz Z, Strug I, …, Norris PJ, Stern LJ
Proc Natl Acad Sci U S A 2004 Sep 7 101(36):13279-84 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Andrea Sant / Gerald Nepom
Evaluated 16 Sep 2004

T cell repertoire scanning is promoted by dynamic dendritic cell behavior and random T cell motility in the lymph node.
Miller MJ, Hejazi AS, …, Cahalan MD, Parker I
Proc Natl Acad Sci U S A 2004 Jan 27 101(4):998-1003 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Michael Dustin / Rick Tarleton / Andrea Sant
Evaluated 10 Aug 2004

Immune recognition of a human renal cancer antigen through post-translational protein splicing.
Hanada K, Yewdell JW, Yang JC
Nature 2004 Jan 15 427(6971):252-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Peter Van Endert / Ulf Pettersson / James Crowe / Tim Elliott / Andrea Sant / Arthur Hurwitz / Shiv Pillai
Evaluated 12 Mar 2004

Saposin C is required for lipid presentation by human CD1b.
Winau F, Schwierzeck V, …, Kaufmann SH, Schaible UE
Nat Immunol 2004 Feb 5(2):169-74 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Andrea Sant / Gerrit van Meer
Evaluated 24 Feb 2004

Local cooperation dominates over competition between CD4+ T cells of different antigen/MHC specificity.
Creusot RJ, Thomsen LL, Tite JP, Chain BM
J Immunol 2003 Jul 1 171(1):240-6 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Andrea Sant
Evaluated 20 Feb 2004

Physiological beta cell death triggers priming of self-reactive T cells by dendritic cells in a type-1 diabetes model.
Turley S, Poirot L, …, Benoist C, Mathis D
J Exp Med 2003 Nov 17 198(10):1527-37 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Andrea Sant / Luciano Adorini / Matthias von Herrath / Torben Lund
Evaluated 27 Nov 2003

Biochemical features of the MHC-related protein 1 consistent with an immunological function.
Miley MJ, Truscott SM, …, Hansen TH, Lybarger L
J Immunol 2003 Jun 15 170(12):6090-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Andrea Sant
Evaluated 5 Nov 2003

The strategy of T cell antigen-presenting cell encounter in antigen-draining lymph nodes revealed by imaging of initial T cell activation.
Bajénoff M, Granjeaud S, Guerder S
J Exp Med 2003 Sep 1 198(5):715-24 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Reina Mebius / Andrea Sant
Evaluated 4 Nov 2003

A naturally selected dimorphism within the HLA-B44 supertype alters class I structure, peptide repertoire, and T cell recognition.
Macdonald WA, Purcell AW, …, Rossjohn J, McCluskey J
J Exp Med 2003 Sep 1 198(5):679-91 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Andrea Sant / Frank Momburg
Evaluated 15 Sep 2003

Continuous T cell receptor signaling required for synapse maintenance and full effector potential.
Huppa JB, Gleimer M, Sumen C, Davis MM
Nat Immunol 2003 Aug 4(8):749-55 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Nick Gascoigne / Anjana Rao / Andrea Sant / Michael Dustin
Evaluated 12 Sep 2003

Differential antigen presentation regulates the changing patterns of CD8+ T cell immunodominance in primary and secondary influenza virus infections.
Crowe SR, Turner SJ, …, Ely KH, Woodland DL
J Exp Med 2003 Aug 4 198(3):399-410 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Peter Van Endert / Barry Rouse / Andrea Sant / Leo Lefrancois
Evaluated 21 Aug 2003

Competition between two MHC binding registers in a single peptide processed from myelin basic protein influences tolerance and susceptibility to autoimmunity.
Seamons A, Sutton J, …, Beeson C, Goverman J
J Exp Med 2003 May 19 197(10):1391-7 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Andrea Sant / Peter Van Endert
Evaluated 22 May 2003

Components of the ligand for a Ni++ reactive human T cell clone.
Lu L, Vollmer J, …, Marrack P, Kappler J
J Exp Med 2003 Mar 3 197(5):567-74 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Andrea Sant
Evaluated 1 Apr 2003

Dynamic changes during the immune response in T cell-antigen-presenting cell clusters isolated from lymph nodes.
Hommel M, Kyewski B
J Exp Med 2003 Feb 3 197(3):269-80 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Andrea Sant / Leo Lefrancois
Evaluated 6 Feb 2003

Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell tolerance.
Bonifaz L, Bonnyay D, …, Nussenzweig MC, Steinman RM
J Exp Med 2002 Dec 16 196(12):1627-38 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Andrea Sant
Evaluated 22 Jan 2003

A pH-sensitive histidine residue as control element for ligand release from HLA-DR molecules.
Rötzschke O, Lau JM, …, Falk K, Strominger JL
Proc Natl Acad Sci U S A 2002 Dec 24 99(26):16946-50 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Andrea Sant / Peter Jensen
Evaluated 18 Dec 2002

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