homefeedbacksupportlog on 5-Jul-2008 
  About F1000

 What is F1000 Biology?
 Key features
 How it's organized
 FAQs
 Faculties and sections
 Scope of sections
 List of Faculty Members
 The evaluation system
 Citing F1000
 Take a tour of the site
 Accessing fulltexts
 PubMed linkout
 How to subscribe
 Academic subscriptions
 Corporate subscriptions
 Try F1000 for free
 Who we are
 Media information
 Librarian resources
 Press releases
 In the press
 Developing countries
 F1000 Medicine
 Terms and conditions
 Privacy policy
 Contact us


Philip Coffino
Department of Microbiology, University of California, San Francisco, United States of America

Faculty Member: DEVELOPMENTAL BIOLOGY > Developmental molecular mechanisms [ since 17 October 2002 ]
[ Homepage ] [ Evaluations ]
Home page

http://www.ucsf.edu/micro/faculty/Coffino/index.html

to email [Help]
Evaluations

Stability of the proteasome can be regulated allosterically through engagement of its proteolytic active sites.
Kleijnen MF, Roelofs J, …, King RW, Finley D
Nat Struct Mol Biol 2007 Dec 14(12):1180-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Philip Coffino
Evaluated 6 Dec 2007

A ubiquitin stress response induces altered proteasome composition.
Hanna J, Meides A, Zhang DP, Finley D
Cell 2007 May 18 129(4):747-59 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Philip Coffino
Evaluated 7 Jun 2007

Protein synthesis upon acute nutrient restriction relies on proteasome function.
Vabulas RM, Hartl FU
Science 2005 Dec 23 310(5756):1960-3 [abstract on PubMed] [related articles] [FREE full text]
Selected by | David Ron / Christopher Nicchitta / Philip Coffino
Evaluated 26 Apr 2006

Rebuilt AAA + motors reveal operating principles for ATP-fuelled machines.
Martin A, Baker TA, Sauer RT
Nature 2005 Oct 20 437(7062):1115-20 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Philip Coffino / Regine Hengge / Laura Itzhaki
Evaluated 11 Nov 2005

5-Aza-deoxycytidine induces selective degradation of DNA methyltransferase 1 by a proteasomal pathway that requires the KEN box, bromo-adjacent homology domain, and nuclear localization signal.
Ghoshal K, Datta J, …, Motiwala T, Jacob ST
Mol Cell Biol 2005 Jun 25(11):4727-41 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Philip Coffino
Evaluated 27 May 2005

Partitioning between unfolding and release of native domains during ClpXP degradation determines substrate selectivity and partial processing.
Kenniston JA, Baker TA, Sauer RT
Proc Natl Acad Sci U S A 2005 Feb 1 102(5):1390-5 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Philip Coffino
Evaluated 15 Feb 2005

Antizyme targets cyclin D1 for degradation. A novel mechanism for cell growth repression.
Newman RM, Mobascher A, …, Finley D, Zetter BR
J Biol Chem 2004 Oct 1 279(40):41504-11 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Philip Coffino
Evaluated 10 Aug 2004

Sem1p is a novel subunit of the 26 S proteasome from Saccharomyces cerevisiae.
Sone T, Saeki Y, Toh-e A, Yokosawa H
J Biol Chem 2004 Jul 2 279(27):28807-16 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Philip Coffino
Evaluated 10 Jun 2004

Localization to the proteasome is sufficient for degradation.
Janse DM, Crosas B, Finley D, Church GM
J Biol Chem 2004 May 14 279(20):21415-20 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Philip Coffino
Evaluated 6 Apr 2004

Structural determinants for the intracellular degradation of human thymidylate synthase.
Forsthoefel AM, Peña MM, …, Rafique Z, Berger FG
Biochemistry 2004 Feb 24 43(7):1972-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Philip Coffino
Evaluated 17 Mar 2004

Proteasome-mediated degradation of p21 via N-terminal ubiquitinylation.
Bloom J, Amador V, …, DeMartino G, Pagano M
Cell 2003 Oct 3 115(1):71-82 [abstract on PubMed] [related articles] [order article]
Selected by | Arp Schnittger / Philip Coffino
Evaluated 20 Nov 2003

Function of the p97-Ufd1-Npl4 complex in retrotranslocation from the ER to the cytosol: dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chains.
Ye Y, Meyer HH, Rapoport TA
J Cell Biol 2003 Jul 7 162(1):71-84 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Philip Coffino
Evaluated 21 Jul 2003

Role of proteasomes in the degradation of short-lived proteins in human fibroblasts under various growth conditions.
Fuertes G, Villarroya A, Knecht E
Int J Biochem Cell Biol 2003 May 35(5):651-64 [abstract on PubMed] [related articles] [order article]
Selected by | Philip Coffino
Evaluated 8 Apr 2003

Proteasome-dependent, ubiquitin-independent degradation of the Rb family of tumor suppressors by the human cytomegalovirus pp71 protein.
Kalejta RF, Shenk T
Proc Natl Acad Sci U S A 2003 Mar 18 100(6):3263-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Philip Coffino
Evaluated 14 Mar 2003

Endoproteolytic activity of the proteasome.
Liu CW, Corboy MJ, DeMartino GN, Thomas PJ
Science 2003 Jan 17 299(5605):408-11 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Philip Coffino / Karin Romisch
Evaluated 20 Jan 2003

The N-terminal truncated isoform of SOCS3 translated from an alternative initiation AUG codon under stress conditions is stable due to the lack of a major ubiquitination site, Lys-6.
Sasaki A, Inagaki-Ohara K, …, Koromilas AE, Yoshimura A
J Biol Chem 2003 Jan 24 278(4):2432-6 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Philip Coffino
Evaluated 13 Dec 2002

Mdm-2 and ubiquitin-independent p53 proteasomal degradation regulated by NQO1.
Asher G, Lotem J, …, Kahana C, Shaul Y
Proc Natl Acad Sci U S A 2002 Oct 1 99(20):13125-30 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Philip Coffino
Evaluated 29 Oct 2002

Role of Rpn11 metalloprotease in deubiquitination and degradation by the 26S proteasome.
Verma R, Aravind L, …, Koonin EV, Deshaies RJ
Science 2002 Oct 18 298(5593):611-5 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Judy Callis / Philip Coffino
Evaluated 25 Oct 2002

^Top  Back to Faculty Members


© 1999-2008 Biology Reports Ltd unless otherwise stated < info@f1000.com >   Terms and conditions   Legal info