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Kermit Carraway
Department of Cell Biology and Anatomy, University of Miami School of Medicine, Miami, United States of America

Faculty Member: CELL BIOLOGY > Cell signalling [ since 9 January 2002 ]
[ Sponsorship ] [ Evaluations ]
Sponsorship

Kermit Carraway sponsors free access to F1000 for University of the West Indies at Mona, Kingston, Jamaica. Supporting F1000's initiative to make itself available to scientists in all countries, including free access to developing countries (more details).

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Evaluations

Caspase Cleavage of HER-2 Releases a Bad-like Cell Death Effector.
Strohecker AM, Yehiely F, Chen F, Cryns VL
J Biol Chem 2008 Jun 27 283(26):18269-82 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Kermit Carraway
Evaluated 30 Jun 2008

Regulation of TGF-{beta} signalling by N-acetylgalactosaminyltransferase-like 1.
Herr P, Korniychuk G, …, Grubisic K, Oelgeschläger M
Development 2008 May 135(10):1813-22 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Kermit Carraway
Evaluated 1 May 2008

Regulation of Myoblast Motility and Fusion by the CXCR4-associated Sialomucin, CD164.
Bae GU, Gaio U, …, Kang JS, Krauss RS
J Biol Chem 2008 Mar 28 283(13):8301-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Kermit Carraway
Evaluated 27 Mar 2008

Immediate-early signaling induced by E-cadherin engagement and adhesion.
Perez TD, Tamada M, Sheetz MP, Nelson WJ
J Biol Chem 2007 Dec 17 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Deborah Leckband / Kermit Carraway
Evaluated 21 Feb 2008

Cdc42 Regulates E-cadherin Ubiquitination and Degradation through an Epidermal Growth Factor Receptor to Src-mediated Pathway.
Shen Y, Hirsch DS, Sasiela CA, Wu WJ
J Biol Chem 2008 Feb 22 283(8):5127-5137 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Kermit Carraway
Evaluated 20 Feb 2008

A Critical Role for HSP90 in Cancer Cell Invasion Involves Interaction with the Extracellular Domain of HER-2.
Sidera K, Gaitanou M, …, Matsas R, Patsavoudi E
J Biol Chem 2008 Jan 25 283(4):2031-41 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Kermit Carraway
Evaluated 29 Jan 2008

Mutational activation of ErbB2 reveals a new protein kinase autoinhibition mechanism.
Fan YX, Wong L, …, Johnson RC, Johnson GR
J Biol Chem 2008 Jan 18 283(3):1588-96 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Kermit Carraway
Evaluated 16 Jan 2008

Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies.
Stommel JM, Kimmelman AC, …, Chin L, DePinho RA
Science 2007 Oct 12 318(5848):287-90 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Kermit Carraway / Simon Cook
Evaluated 23 Oct 2007

Glucosamine hydrochloride specifically inhibits COX-2 by preventing COX-2 N-glycosylation and by increasing COX-2 protein turnover in a proteasome-dependent manner.
Jang BC, Sung SH, …, Han SB, Suh SI
J Biol Chem 2007 Sep 21 282(38):27622-32 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Kermit Carraway
Evaluated 17 Sep 2007

Transmembrane mucins Hkr1 and Msb2 are putative osmosensors in the SHO1 branch of yeast HOG pathway.
Tatebayashi K, Tanaka K, …, Imai M, Saito H
EMBO J 2007 Aug 8 26(15):3521-33 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Kermit Carraway / Francesc Posas
Evaluated 23 Jul 2007

MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling.
Engelman JA, Zejnullahu K, …, Cantley LC, Jänne PA
Science 2007 May 18 316(5827):1039-43 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | William Kaelin / Kermit Carraway
Evaluated 30 May 2007


Post-translational palmitoylation and glycosylation of Wnt-5a are necessary for its signalling.
Kurayoshi M, Yamamoto H, Izumi S, Kikuchi A
Biochem J 2007 Mar 15 402(3):515-23 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Kermit Carraway
Evaluated 2 May 2007

Integration of TGF-beta and Ras/MAPK signaling through p53 phosphorylation.
Cordenonsi M, Montagner M, …, Dupont S, Piccolo S
Science 2007 Feb 9 315(5813):840-3 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Michael Weber / Kermit Carraway / Andrius Kazlauskas / Takashi Tsuruo
Evaluated 21 Feb 2007

Live-cell imaging of enzyme-substrate interaction reveals spatial regulation of PTP1B.
Yudushkin IA, Schleifenbaum A, …, Schultz C, Bastiaens PI
Science 2007 Jan 5 315(5808):115-9 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Kermit Carraway / Amy Barrios / Dafna Bar-Sagi / Karen Allen
Evaluated 22 Jan 2007

Hepatocyte growth factor-induced Ras activation requires ERM proteins linked to both CD44v6 and F-actin.
Orian-Rousseau V, Morrison H, …, Herrlich P, Ponta H
Mol Biol Cell 2007 Jan 18(1):76-83 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Kermit Carraway
Evaluated 12 Jan 2007

Abl tyrosine kinase regulates endocytosis of the epidermal growth factor receptor.
Tanos B, Pendergast AM
J Biol Chem 2006 Oct 27 281(43):32714-23 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Kermit Carraway
Evaluated 31 Oct 2006

MUC1 oncoprotein blocks nuclear targeting of c-Abl in the apoptotic response to DNA damage.
Raina D, Ahmad R, …, Kharbanda S, Kufe D
EMBO J 2006 Aug 23 25(16):3774-83 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Kermit Carraway
Evaluated 20 Oct 2006

Decorin protein core inhibits in vivo cancer growth and metabolism by hindering epidermal growth factor receptor function and triggering apoptosis via caspase-3 activation.
Seidler DG, Goldoni S, …, McQuillan DJ, Iozzo RV
J Biol Chem 2006 Sep 8 281(36):26408-18 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Kermit Carraway
Evaluated 8 Sep 2006

N-glycosylation affects the molecular organization and stability of E-cadherin junctions.
Liwosz A, Lei T, Kukuruzinska MA
J Biol Chem 2006 Aug 11 281(32):23138-49 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Deborah Leckband / Kermit Carraway
Evaluated 14 Aug 2006

Rac1 links integrin-mediated adhesion to the control of lactational differentiation in mammary epithelia.
Akhtar N, Streuli CH
J Cell Biol 2006 Jun 5 173(5):781-93 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Kermit Carraway
Evaluated 31 Jul 2006

The ERBB4/HER4 intracellular domain 4ICD is a BH3-only protein promoting apoptosis of breast cancer cells.
Naresh A, Long W, …, Bartlett JM, Jones FE
Cancer Res 2006 Jun 15 66(12):6412-20 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Kermit Carraway
Evaluated 26 Jul 2006

Cell-cell interaction-dependent regulation of N-acetylglucosaminyltransferase III and the bisected N-glycans in GE11 epithelial cells. Involvement of E-cadherin-mediated cell adhesion.
Iijima J, Zhao Y, …, Taniguchi N, Gu J
J Biol Chem 2006 May 12 281(19):13038-46 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Kermit Carraway
Evaluated 30 May 2006

Tumor invasion in the absence of epithelial-mesenchymal transition: podoplanin-mediated remodeling of the actin cytoskeleton.
Wicki A, Lehembre F, …, Kerjaschki D, Christofori G
Cancer Cell 2006 Apr 9(4):261-72 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Kermit Carraway
Evaluated 26 Apr 2006

Core fucosylation regulates epidermal growth factor receptor-mediated intracellular signaling.
Wang X, Gu J, …, Honke K, Taniguchi N
J Biol Chem 2006 Feb 3 281(5):2572-7 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Kermit Carraway
Evaluated 2 Feb 2006

A protein kinase C/Ras/ERK signaling pathway activates myeloid fibronectin receptors by altering beta1 integrin sialylation.
Seales EC, Shaikh FM, …, Hennessy KM, Bellis SL
J Biol Chem 2005 Nov 11 280(45):37610-5 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Kermit Carraway
Evaluated 9 Nov 2005

The beta-glucuronidase klotho hydrolyzes and activates the TRPV5 channel.
Chang Q, Hoefs S, …, Bindels RJ, Hoenderop JG
Science 2005 Oct 21 310(5747):490-3 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Kermit Carraway / Bernd Nilius / Linda C. Hsieh-Wilson / Jens Leipziger
Evaluated 7 Nov 2005

Perturbations in O-linked beta-N-acetylglucosamine protein modification cause severe defects in mitotic progression and cytokinesis.
Slawson C, Zachara NE, …, Lane MD, Hart GW
J Biol Chem 2005 Sep 23 280(38):32944-56 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Kermit Carraway
Evaluated 20 Sep 2005

Highly conserved O-fucose sites have distinct effects on Notch1 function.
Rampal R, Arboleda-Velasquez JF, …, Kosik KS, Haltiwanger RS
J Biol Chem 2005 Sep 16 280(37):32133-40 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Kermit Carraway
Evaluated 20 Sep 2005

Molecular mechanism for switching of P. falciparum invasion pathways into human erythrocytes.
Stubbs J, Simpson KM, …, Winzeler EA, Cowman AF
Science 2005 Aug 26 309(5739):1384-7 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Kermit Carraway
Evaluated 9 Sep 2005

Mitogenic influence of human R-spondin1 on the intestinal epithelium.
Kim KA, Kakitani M, …, Funk WD, Tomizuka K
Science 2005 Aug 19 309(5738):1256-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Kermit Carraway / Matthew Breyer
Evaluated 2 Sep 2005

Stem cell depletion through epidermal deletion of Rac1.
Benitah SA, Frye M, Glogauer M, Watt FM
Science 2005 Aug 5 309(5736):933-5 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Bruce Morgan / Kermit Carraway
Evaluated 22 Aug 2005

Functional genomic analysis of the Wnt-wingless signaling pathway.
DasGupta R, Kaykas A, Moon RT, Perrimon N
Science 2005 May 6 308(5723):826-33 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Alfonso Martinez Arias / Bruce Morgan / Kermit Carraway / Valeri Vasioukhin
Evaluated 17 May 2005

Chaperone activity of protein O-fucosyltransferase 1 promotes notch receptor folding.
Okajima T, Xu A, Lei L, Irvine KD
Science 2005 Mar 11 307(5715):1599-603 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Kermit Carraway / Marek Mlodzik
Evaluated 24 Mar 2005

Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response.
Wei X, Xu H, Kufe D
Cancer Cell 2005 Feb 7(2):167-78 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Kermit Carraway
Evaluated 21 Mar 2005

The kaposin B protein of KSHV activates the p38/MK2 pathway and stabilizes cytokine mRNAs.
McCormick C, Ganem D
Science 2005 Feb 4 307(5710):739-41 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Roy Long / Kermit Carraway / W. Ian Lipkin
Evaluated 23 Feb 2005

Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1.
O'Neill E, Rushworth L, Baccarini M, Kolch W
Science 2004 Dec 24 306(5705):2267-70 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Kermit Carraway / Angel Nebreda
Evaluated 10 Jan 2005

The kinase activity of fibroblast growth factor receptor 3 with activation loop mutations affects receptor trafficking and signaling.
Lievens PM, Mutinelli C, Baynes D, Liboi E
J Biol Chem 2004 Oct 8 279(41):43254-60 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Kermit Carraway
Evaluated 26 Nov 2004

Regulation of cytokine receptors by Golgi N-glycan processing and endocytosis.
Partridge EA, Le Roy C, …, Wrana JL, Dennis JW
Science 2004 Oct 1 306(5693):120-4 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Kermit Carraway
Evaluated 14 Oct 2004

O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer's disease.
Liu F, Iqbal K, …, Hart GW, Gong CX
Proc Natl Acad Sci U S A 2004 Jul 20 101(29):10804-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Kermit Carraway
Evaluated 24 Aug 2004

Natural antibiotic function of a human gastric mucin against Helicobacter pylori infection.
Kawakubo M, Ito Y, …, Katsuyama T, Nakayama J
Science 2004 Aug 13 305(5686):1003-6 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Kermit Carraway
Evaluated 24 Aug 2004

HER-2 gene amplification can be acquired as breast cancer progresses.
Meng S, Tripathy D, …, Wang J, Uhr J
Proc Natl Acad Sci U S A 2004 Jun 22 101(25):9393-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Kermit Carraway
Evaluated 29 Jul 2004

Functional mapping of Ca2+ signaling complexes in plasma membrane microdomains of polarized cells.
Li Q, Luo X, Muallem S
J Biol Chem 2004 Jul 2 279(27):27837-40 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Kermit Carraway
Evaluated 7 Jul 2004

Mutational analysis of the tyrosine phosphatome in colorectal cancers.
Wang Z, Shen D, …, Vogelstein B, Velculescu VE
Science 2004 May 21 304(5674):1164-6 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Kermit Carraway / Zhong-Yin Zhang / Angus Nairn / Richard L. Stevens / Ulf Pettersson
Evaluated 2 Jun 2004

Protein tyrosine phosphatase-1B dephosphorylation of the insulin receptor occurs in a perinuclear endosome compartment in human embryonic kidney 293 cells.
Romsicki Y, Reece M, …, Asante-Appiah E, Kennedy BP
J Biol Chem 2004 Mar 26 279(13):12868-75 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Kermit Carraway
Evaluated 14 Apr 2004

Specific N-glycans direct apical delivery of transmembrane, but not soluble or glycosylphosphatidylinositol-anchored forms of endolyn in Madin-Darby canine kidney cells.
Potter BA, Ihrke G, …, Weixel KM, Weisz OA
Mol Biol Cell 2004 Mar 15(3):1407-16 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Kermit Carraway
Evaluated 14 Apr 2004

Localized stabilization of microtubules by integrin- and FAK-facilitated Rho signaling.
Palazzo AF, Eng CH, …, Marcantonio EE, Gundersen GG
Science 2004 Feb 6 303(5659):836-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Orly Reiner / Kermit Carraway / Ed Manser / Martin Humphries
Evaluated 23 Feb 2004

Integrins regulate Rac targeting by internalization of membrane domains.
del Pozo MA, Alderson NB, …, Anderson RG, Schwartz MA
Science 2004 Feb 6 303(5659):839-42 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Valeri Vasioukhin / Robert Parton / Kermit Carraway / Anna Huttenlocher / Martin Humphries / Charles Streuli
Evaluated 23 Feb 2004

EGF-like growth factors as mediators of LH action in the ovulatory follicle.
Park JY, Su YQ, …, Jin SL, Conti M
Science 2004 Jan 30 303(5658):682-4 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Kermit Carraway
Evaluated 17 Feb 2004

Defining the epithelial stem cell niche in skin.
Tumbar T, Guasch G, …, Rendl M, Fuchs E
Science 2004 Jan 16 303(5656):359-63 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Bruce Morgan / Kenneth Yamada / Kermit Carraway
Evaluated 3 Feb 2004

A genetic screen in Drosophila for metastatic behavior.
Pagliarini RA, Xu T
Science 2003 Nov 14 302(5648):1227-31 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Erez Raz / Valeri Vasioukhin / Kermit Carraway / Dafna Bar-Sagi / David Bilder
Evaluated 1 Dec 2003

Bidirectional transmembrane signaling by cytoplasmic domain separation in integrins.
Kim M, Carman CV, Springer TA
Science 2003 Sep 19 301(5640):1720-5 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Michael Dustin / Klaus Ley / Kermit Carraway / Peter Ekblom / Jean Schwarzbauer / Charles Streuli
Evaluated 15 Oct 2003

BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis.
Danial NN, Gramm CF, …, Gygi SP, Korsmeyer SJ
Nature 2003 Aug 21 424(6951):952-6 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Atan Gross / Kermit Carraway
Evaluated 9 Sep 2003

Inhibition of neuroepithelial patched-induced apoptosis by sonic hedgehog.
Thibert C, Teillet MA, …, Le Douarin NM, Mehlen P
Science 2003 Aug 8 301(5634):843-6 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Kermit Carraway / Silvio Gutkind / Judith S. Eisen
Evaluated 1 Sep 2003

Role of Raf in vascular protection from distinct apoptotic stimuli.
Alavi A, Hood JD, …, Stupack DG, Cheresh DA
Science 2003 Jul 4 301(5629):94-6 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Kermit Carraway / Chandra Kumar
Evaluated 21 Jul 2003

Fibronectin requirement in branching morphogenesis.
Sakai T, Larsen M, Yamada KM
Nature 2003 Jun 19 423(6942):876-81 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Kermit Carraway / Lilianna Solnica-Krezel
Evaluated 10 Jul 2003

Glucagon-like peptide 1 (1-37) converts intestinal epithelial cells into insulin-producing cells.
Suzuki A, Nakauchi H, Taniguchi H
Proc Natl Acad Sci U S A 2003 Apr 29 100(9):5034-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Kermit Carraway
Evaluated 29 May 2003

Prospective identification of tumorigenic breast cancer cells.
Al-Hajj M, Wicha MS, …, Morrison SJ, Clarke MF
Proc Natl Acad Sci U S A 2003 Apr 1 100(7):3983-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Andreas Trumpp / Kermit Carraway / Martine Roussel
Evaluated 9 May 2003


Proteomic screen finds pSer/pThr-binding domain localizing Plk1 to mitotic substrates.
Elia AE, Cantley LC, Yaffe MB
Science 2003 Feb 21 299(5610):1228-31 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Sally Kornbluth / Ashok Venkitaraman / Kermit Carraway / Angel Nebreda / Andrew D. Sharrocks / Francis Barr
Evaluated 5 Mar 2003

Rewiring MAP kinase pathways using alternative scaffold assembly mechanisms.
Park SH, Zarrinpar A, Lim WA
Science 2003 Feb 14 299(5609):1061-4 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Kermit Carraway / Dafna Bar-Sagi / Francesc Posas / Deborah Morrison
Evaluated 27 Feb 2003

Disruption of transforming growth factor-beta signaling in ELF beta-spectrin-deficient mice.
Tang Y, Katuri V, …, Deng CX, Mishra L
Science 2003 Jan 24 299(5606):574-7 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Kermit Carraway
Evaluated 27 Feb 2003

Moesin functions antagonistically to the Rho pathway to maintain epithelial integrity.
Speck O, Hughes SC, …, Kulikauskas RM, Fehon RG
Nature 2003 Jan 2 421(6918):83-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jessica E. Treisman / Kermit Carraway / Marta Llimargas / Jeffrey Axelrod / Michel Labouesse
Evaluated 21 Jan 2003

Signaling of rat Frizzled-2 through phosphodiesterase and cyclic GMP.
Ahumada A, Slusarski DC, …, Malbon CC, Wang HY
Science 2002 Dec 6 298(5600):2006-10 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Kermit Carraway
Evaluated 13 Jan 2003

Developmental regulation of intestinal angiogenesis by indigenous microbes via Paneth cells.
Stappenbeck TS, Hooper LV, Gordon JI
Proc Natl Acad Sci U S A 2002 Nov 26 99(24):15451-5 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Kermit Carraway / Robert Palmer
Evaluated 10 Jan 2003

Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains.
Ogiso H, Ishitani R, …, Shirouzu M, Yokoyama S
Cell 2002 Sep 20 110(6):775-87 [abstract on PubMed] [related articles] [order article]
Selected by | Kermit Carraway / Wayne Guida
Evaluated 29 Oct 2002

Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor alpha.
Garrett TP, McKern NM, …, Burgess AW, Ward CW
Cell 2002 Sep 20 110(6):763-73 [abstract on PubMed] [related articles] [order article]
Selected by | Kermit Carraway