Joan Broderick sponsors free access to F1000 for University of the Philippines, Diliman, Quezon City, Philippines. Supporting F1000's initiative to make itself available to scientists in all countries, including free access to developing countries (more details).

RimO, a MiaB-like enzyme, methylthiolates the universally conserved Asp88 residue of ribosomal protein S12 in Escherichia coli. Anton BP, Saleh L, …, Kasif S, Roberts RJ Proc Natl Acad Sci U S A 2008 Feb 12 105(6):1826-31 [abstract on PubMed] [related articles] [FREE full text] Selected by | Joan Broderick Evaluated 5 Mar 2008 Binding energy in the one-electron reductive cleavage of S-adenosylmethionine in lysine 2,3-aminomutase, a radical SAM enzyme. Wang SC, Frey PA Biochemistry 2007 Nov 13 46(45):12889-95 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Rowena Matthews / Joan Broderick Evaluated 18 Dec 2007 Biochemical and spectroscopic studies of the electronic structure and reactivity of a methyl-Ni species formed on methyl-coenzyme M reductase. Dey M, Telser J, …, Ragsdale SW, Hoffman BM J Am Chem Soc 2007 Sep 12 129(36):11030-2 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Joan Broderick Evaluated 7 Sep 2007 Direct spectroscopic evidence for a high-spin Fe(IV) intermediate in tyrosine hydroxylase. Eser BE, Barr EW, …, Krebs C, Fitzpatrick PF J Am Chem Soc 2007 Sep 19 129(37):11334-5 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Joan Broderick Evaluated 7 Sep 2007 Characterization and structure of a Zn2+ and [2Fe-2S]-containing copper chaperone from Archaeoglobus fulgidus. Sazinsky MH, LeMoine B, …, Argüello JM, Rosenzweig AC J Biol Chem 2007 Aug 31 282(35):25950-9 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Joan Broderick Evaluated 31 Jul 2007 Dioldehydrase: an essential role for potassium ion in the homolytic cleavage of the cobalt-carbon bond in adenosylcobalamin. Schwartz PA, Frey PA Biochemistry 2007 Jun 19 46(24):7293-301 [abstract on PubMed] [related articles] [full text] [order article] Selected by | E. Neil G. Marsh / Joan Broderick Evaluated 15 Jun 2007 An insight into the mechanism of human cysteine dioxygenase. Key roles of the thioether-bonded tyrosine-cysteine cofactor. Ye S, Wu X, …, Bartlam M, Rao Z J Biol Chem 2007 Feb 2 282(5):3391-402 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Michael Maroney / Joan Broderick Evaluated 13 Apr 2007 Anaerobic sulfatase-maturating enzymes: radical SAM enzymes able to catalyze in vitro sulfatase post-translational modification. Benjdia A, Leprince J, …, Rabot S, Berteau O J Am Chem Soc 2007 Mar 28 129(12):3462-3 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Joan Broderick Evaluated 3 Apr 2007 Recognition of age-damaged (R,S)-adenosyl-L-methionine by two methyltransferases in the yeast Saccharomyces cerevisiae. Vinci CR, Clarke SG J Biol Chem 2007 Mar 23 282(12):8604-12 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Joan Broderick Evaluated 9 Feb 2007 Connecting nitrogenase intermediates with the kinetic scheme for N2 reduction by a relaxation protocol and identification of the N2 binding state. Lukoyanov D, Barney BM, …, Seefeldt LC, Hoffman BM Proc Natl Acad Sci U S A 2007 Jan 30 104(5):1451-5 [abstract on PubMed] [related articles] [FREE full text] Selected by | Joan Broderick Evaluated 2 Feb 2007 Self-repair of thymine dimer in duplex DNA. Holman MR, Ito T, Rokita SE J Am Chem Soc 2007 Jan 10 129(1):6-7 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Joan Broderick Evaluated 17 Jan 2007 A dynamic Zn site in Helicobacter pylori HypA: a potential mechanism for metal-specific protein activity. Kennedy DC, Herbst RW, …, Chivers PT, Maroney MJ J Am Chem Soc 2007 Jan 10 129(1):16-7 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Joan Broderick Evaluated 16 Jan 2007 How an enzyme tames reactive intermediates: positioning of the active-site components of lysine 2,3-aminomutase during enzymatic turnover as determined by ENDOR spectroscopy. Lees NS, Chen D, …, Frey PA, Hoffman BM J Am Chem Soc 2006 Aug 9 128(31):10145-54 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Joan Broderick Evaluated 13 Sep 2006 Growth substrate dependent localization of tetrachloroethene reductive dehalogenase in Sulfurospirillum multivorans. John M, Schmitz RP, …, Richter W, Diekert G Arch Microbiol 2006 Aug 186(2):99-106 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Joan Broderick Evaluated 1 Aug 2006 pfmdr2 confers heavy metal resistance to Plasmodium falciparum. Rosenberg E, Litus I, …, Lingelbach K, Pollack Y J Biol Chem 2006 Sep 15 281(37):27039-45 [abstract on PubMed] [related articles] [FREE full text] Selected by | Joan Broderick Evaluated 31 Jul 2006 Probing nitrogen-sensitive steps in the free-radical-mediated deamination of amino alcohols by ethanolamine ammonia-lyase. Poyner RR, Anderson MA, …, Cleland WW, Reed GH J Am Chem Soc 2006 Jun 7 128(22):7120-1 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Joan Broderick Evaluated 30 Jun 2006 Effect of copper and manganese on the de novo generation of protease-resistant prion protein in yeast cells. Treiber C, Simons A, Multhaup G Biochemistry 2006 May 30 45(21):6674-80 [abstract on PubMed] [related articles] [FREE full text] Selected by | Joan Broderick Evaluated 5 Jun 2006 Escherichia coli biotin synthase produces selenobiotin. Further evidence of the involvement of the [2Fe-2S]2+ cluster in the sulfur insertion step. Tse Sum Bui B, Mattioli TA, …, Bolbach G, Marquet A Biochemistry 2006 Mar 21 45(11):3824-34 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Wolfgang Buckel / Joan Broderick Evaluated 24 Mar 2006 The active conformation of avilamycin A is conferred by AviX12, a radical AdoMet enzyme. Boll R, Hofmann C, …, Friedrich T, Bechthold A J Biol Chem 2006 May 26 281(21):14756-63 [abstract on PubMed] [related articles] [FREE full text] Selected by | Joan Broderick Evaluated 23 Mar 2006 Crystal structures of catalytic complexes of the oxidative DNA/RNA repair enzyme AlkB. Yu B, Edstrom WC, …, Gibney BR, Hunt JF Nature 2006 Feb 16 439(7078):879-84 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Joan Broderick / Elizabeth Theil / Fraydoon Rastinejad Evaluated 24 Feb 2006 X-ray Structure of a self-compartmentalizing sulfur cycle metalloenzyme. Urich T, Gomes CM, Kletzin A, Frazão C Science 2006 Feb 17 311(5763):996-1000 [abstract on PubMed] [related articles] [FREE full text] Selected by | Joan Broderick / Dianne Newman / Andrea Mattevi / Celerino Abad-Zapatero Evaluated 24 Feb 2006 The Elongator subunit Elp3 contains a Fe4S4 cluster and binds S-adenosylmethionine. Paraskevopoulou C, Fairhurst SA, …, Brick P, Onesti S Mol Microbiol 2006 Feb 59(3):795-806 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Joan Broderick Evaluated 24 Feb 2006 The essential WD40 protein Cia1 is involved in a late step of cytosolic and nuclear iron-sulfur protein assembly. Balk J, Aguilar Netz DJ, …, Pierik AJ, Lill R Mol Cell Biol 2005 Dec 25(24):10833-41 [abstract on PubMed] [related articles] [FREE full text] Selected by | Joan Broderick Evaluated 9 Dec 2005 Intermediates trapped during nitrogenase reduction of N triple bond N, CH3-N=NH, and H2N-NH2. Barney BM, Yang TC, …, Dean DR, Seefeldt LC J Am Chem Soc 2005 Nov 2 127(43):14960-1 [abstract on PubMed] [related articles] [FREE full text] Selected by | Edward Stiefel / Jon Zubieta / Karen Allen / Joan Broderick Evaluated 6 Dec 2005 Crystal structure of a membrane-bound metalloenzyme that catalyses the biological oxidation of methane. Lieberman RL, Rosenzweig AC Nature 2005 Mar 10 434(7030):177-82 [abstract on PubMed] [related articles] [full text] [order article] Selected by | David Richardson / Joan Broderick / E. Neil G. Marsh / Marc Fontecave Evaluated 1 Apr 2005 Nar1p, a conserved eukaryotic protein with similarity to Fe-only hydrogenases, functions in cytosolic iron-sulphur protein biogenesis. Balk J, Pierik AJ, …, Mühlenhoff U, Lill R Biochem Soc Trans 2005 Feb 33(Pt 1):86-9 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Joan Broderick Evaluated 16 Feb 2005 Characterization of MOCS1A, an oxygen-sensitive iron-sulfur protein involved in human molybdenum cofactor biosynthesis. Hänzelmann P, Hernández HL, …, Mendel RR, Schindelin H J Biol Chem 2004 Aug 13 279(33):34721-32 [abstract on PubMed] [related articles] [FREE full text] Selected by | Joan Broderick Evaluated 4 Aug 2004 Insight into the mechanism of the B12-independent glycerol dehydratase from Clostridium butyricum: preliminary biochemical and structural characterization. O'Brien JR, Raynaud C, …, Soucaille P, Lanzilotta WN Biochemistry 2004 Apr 27 43(16):4635-45 [abstract on PubMed] [related articles] [full text] [order article] Selected by | E. Neil G. Marsh / Mark Nelson / Joan Broderick Evaluated 4 Aug 2004 Discovery of two novel radical S-adenosylmethionine proteins required for the assembly of an active [Fe] hydrogenase. Posewitz MC, King PW, …, Seibert M, Ghirardi ML J Biol Chem 2004 Jun 11 279(24):25711-20 [abstract on PubMed] [related articles] [FREE full text] Selected by | Joan Broderick / Marc Fontecave Evaluated 24 Jun 2004 Lipoyl synthase requires two equivalents of S-adenosyl-L-methionine to synthesize one equivalent of lipoic acid. Cicchillo RM, Iwig DF, …, Tu L, Booker SJ Biochemistry 2004 Jun 1 43(21):6378-86 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Joan Broderick Evaluated 9 Jun 2004 Post-translational formylglycine modification of bacterial sulfatases by the radical S-adenosylmethionine protein AtsB. Fang Q, Peng J, Dierks T J Biol Chem 2004 Apr 9 279(15):14570-8 [abstract on PubMed] [related articles] [FREE full text] Selected by | Joan Broderick Evaluated 21 Apr 2004 Nitrilotriacetic acid-modified magnetic nanoparticles as a general agent to bind histidine-tagged proteins. Xu C, Xu K, …, Zhang X, Xu B J Am Chem Soc 2004 Mar 24 126(11):3392-3 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Joan Broderick / Vincent Rotello Evaluated 24 Mar 2004 Impact of protein denaturants and stabilizers on water structure. Batchelor JD, Olteanu A, Tripathy A, Pielak GJ J Am Chem Soc 2004 Feb 25 126(7):1958-61 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Joan Broderick Evaluated 17 Mar 2004 Role of the [2Fe-2S] cluster in recombinant Escherichia coli biotin synthase. Jameson GN, Cosper MM, …, Johnson MK, Huynh BH Biochemistry 2004 Feb 24 43(7):2022-31 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Joan Broderick Evaluated 23 Feb 2004 Repair of guanyl radicals in plasmid DNA by electron transfer is coupled to proton transfer. Milligan JR, Aguilera JA, …, Tran NQ, Ward JF J Am Chem Soc 2004 Feb 18 126(6):1682-7 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Joan Broderick Evaluated 20 Feb 2004 Structural basis for removal of adenine mispaired with 8-oxoguanine by MutY adenine DNA glycosylase. Fromme JC, Banerjee A, Huang SJ, Verdine GL Nature 2004 Feb 12 427(6975):652-6 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Joan Broderick / Stephen Lloyd / Laurence Pearl Evaluated 20 Feb 2004 Crystal structure of coproporphyrinogen III oxidase reveals cofactor geometry of Radical SAM enzymes. Layer G, Moser J, …, Jahn D, Schubert WD EMBO J 2003 Dec 1 22(23):6214-24 [abstract on PubMed] [related articles] [FREE full text] Selected by | Joan Broderick Evaluated 30 Jan 2004 Crystal structure of biotin synthase, an S-adenosylmethionine-dependent radical enzyme. Berkovitch F, Nicolet Y, …, Jarrett JT, Drennan CL Science 2004 Jan 2 303(5654):76-9 [abstract on PubMed] [related articles] [FREE full text] Selected by | Christopher Schofield / Rowena Matthews / Joan Broderick / Mark Nelson Evaluated 30 Jan 2004 Evidence for hydrogen abstraction from C1 of taurine by the high-spin Fe(IV) intermediate detected during oxygen activation by taurine:alpha-ketoglutarate dioxygenase (TauD). Price JC, Barr EW, …, Krebs C, Bollinger JM J Am Chem Soc 2003 Oct 29 125(43):13008-9 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Joan Broderick Evaluated 20 Nov 2003 Computational studies on the A cluster of acetyl-coenzyme A synthase: geometric and electronic properties of the NiFeC species and mechanistic implications. Schenker RP, Brunold TC J Am Chem Soc 2003 Nov 19 125(46):13962-3 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Joan Broderick Evaluated 20 Nov 2003 Subcellular compartmentalization of human Nfu, an iron-sulfur cluster scaffold protein, and its ability to assemble a [4Fe-4S] cluster. Tong WH, Jameson GN, Huynh BH, Rouault TA Proc Natl Acad Sci U S A 2003 Aug 19 100(17):9762-7 [abstract on PubMed] [related articles] [FREE full text] Selected by | Joan Broderick Evaluated 25 Sep 2003 The first experimental test of the hypothesis that enzymes have evolved to enhance hydrogen tunneling. Doll KM, Bender BR, Finke RG J Am Chem Soc 2003 Sep 10 125(36):10877-84 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Joan Broderick / Arieh Warshel / Wolfgang Buckel Evaluated 18 Sep 2003 Novel antioxidant role of alcohol dehydrogenase E from Escherichia coli. Echave P, Tamarit J, Cabiscol E, Ros J J Biol Chem 2003 Aug 8 278(32):30193-8 [abstract on PubMed] [related articles] [FREE full text] Selected by | Joan Broderick Evaluated 18 Sep 2003 The first direct characterization of a high-valent iron intermediate in the reaction of an alpha-ketoglutarate-dependent dioxygenase: a high-spin FeIV complex in taurine/alpha-ketoglutarate dioxygenase (TauD) from Escherichia coli. Price JC, Barr EW, …, Bollinger JM, Krebs C Biochemistry 2003 Jun 24 42(24):7497-508 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Joan Broderick Evaluated 30 Jun 2003 Tyrosine 89 accelerates Co-carbon bond homolysis in methylmalonyl-CoA mutase. Vlasie MD, Banerjee R J Am Chem Soc 2003 May 7 125(18):5431-5 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Joan Broderick Evaluated 27 Jun 2003 A metal-binding site in the catalytic subunit of anaerobic ribonucleotide reductase. Logan DT, Mulliez E, …, Sjoberg BM, Fontecave M Proc Natl Acad Sci U S A 2003 Apr 1 100(7):3826-31 [abstract on PubMed] [related articles] [FREE full text] Selected by | Joan Broderick Evaluated 10 Apr 2003 Purified particulate methane monooxygenase from Methylococcus capsulatus (Bath) is a dimer with both mononuclear copper and a copper-containing cluster. Lieberman RL, Shrestha DB, …, Stemmler TL, Rosenzweig AC Proc Natl Acad Sci U S A 2003 Apr 1 100(7):3820-5 [abstract on PubMed] [related articles] [FREE full text] Selected by | Joan Broderick Evaluated 20 Mar 2003 Modulation of substrate binding to naphthalene 1,2-dioxygenase by rieske cluster reduction/oxidation. Yang TC, Wolfe MD, …, Lipscomb JD, Hoffman BM J Am Chem Soc 2003 Feb 26 125(8):2034-5 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Joan Broderick Evaluated 18 Mar 2003 Control of adenosylmethionine-dependent radical generation in biotin synthase: a kinetic and thermodynamic analysis of substrate binding to active and inactive forms of BioB. Ugulava NB, Frederick KK, Jarrett JT Biochemistry 2003 Mar 11 42(9):2708-19 [abstract on PubMed] [related articles] [FREE full text] Selected by | Joan Broderick Evaluated 18 Mar 2003 Spectroscopic evidence for site specific chemistry at a unique iron site of the [4Fe-4S] cluster in ferredoxin:thioredoxin reductase. Jameson GN, Walters EM, …, Johnson MK, Huynh BH J Am Chem Soc 2003 Feb 5 125(5):1146-7 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Joan Broderick Evaluated 18 Mar 2003 Crystal structure of naphthalene dioxygenase: side-on binding of dioxygen to iron. Karlsson A, Parales JV, …, Eklund H, Ramaswamy S Science 2003 Feb 14 299(5609):1039-42 [abstract on PubMed] [related articles] [FREE full text] Selected by | Joan Broderick / Marc Fontecave Evaluated 10 Mar 2003 Crystallographic and spectroscopic characterization of a nonheme Fe(IV)-O complex. Rohde JU, In JH, …, Nam W, Que L Science 2003 Feb 14 299(5609):1037-9 [abstract on PubMed] [related articles] [FREE full text] Selected by | Joan Broderick / Marc Fontecave / Christopher Schofield Evaluated 10 Mar 2003 Very high-field EPR study of glycyl radical enzymes. Duboc-Toia C, Hassan AK, …, Leutwein C, Heider J J Am Chem Soc 2003 Jan 8 125(1):38-9 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Joan Broderick Evaluated 27 Jan 2003 Low intracellular zinc induces oxidative DNA damage, disrupts p53, NFkappa B, and AP1 DNA binding, and affects DNA repair in a rat glioma cell line. Ho E, Ames BN Proc Natl Acad Sci U S A 2002 Dec 24 99(26):16770-5 [abstract on PubMed] [related articles] [FREE full text] Selected by | Joan Broderick Evaluated 27 Jan 2003 The PcoC copper resistance protein coordinates Cu(I) via novel S-methionine interactions. Peariso K, Huffman DL, Penner-Hahn JE, O'Halloran TV J Am Chem Soc 2003 Jan 15 125(2):342-3 [abstract on PubMed] [related articles] [full text] [order article] Selected by | Joan Broderick Evaluated 14 Jan 2003 An iron-responsive element type II in the 5'-untranslated region of the Alzheimer's amyloid precursor protein transcript. Rogers JT, Randall JD, …, Giordano T, Gullans SR J Biol Chem 2002 Nov 22 277(47):45518-28 [abstract on PubMed] [related articles] [FREE full text] Selected by | Joan Broderick Evaluated 26 Nov 2002 A Ni-Fe-Cu center in a bifunctional carbon monoxide dehydrogenase/acetyl-CoA synthase. Doukov TI, Iverson TM, …, Ragsdale SW, Drennan CL Science 2002 Oct 18 298(5593):567-72 [abstract on PubMed] [related articles] [FREE full text] Selected by | Ruma Banerjee / Wolfgang Buckel / Joan Broderick Evaluated 28 Oct 2002

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