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Judith S. Eisen
Department of Biology, University of Oregon, Eugene, United States of America

Faculty Member: NEUROSCIENCE > Neurodevelopment [ since 13 June 2001 ]
[ Sponsorship ] [ Biography ] [ Homepage ] [ Evaluations ]
Sponsorship

Judith S. Eisen sponsors free access to F1000 for University of Cape Town, South Africa. Supporting F1000's initiative to make itself available to scientists in all countries, including free access to developing countries (more details).

Biography

Specification and patterning of neurons and neural crest cells in embryonic zebrafish.
The vertebrate nervous system is composed of a large number of neurons with diverse characteristics. My lab is interested in how neuronal diversity is generated during development: how are the correct number of cells specified for specific neuronal fates at particular times and in particular locations? Most of our attention has been focused on a small, early-developing set of individually identified spinal motoneurons and on the neural crest, a transient embryonic cell population that generates a diverse set of derivatives, including the neurons and glia of the peripheral nervous system. We use a combined cellular, molecular and genetic approach to learn the mechanisms underlying cell fate specification. For example, we study the timing of critical events during development of motoneurons and neural crest cells by labeling individual cells and following their development in living embryos and by transplanting individual cells to new locations. We are isolating genes encoding molecules that may regulate motoneuron and neural crest development and testing the roles of the proteins encoded by these genes during motoneuron and neural crest specification and differentiation. We are also isolating mutations that alter motoneuron or neural crest cell fate with the goal of identifying new genes involved in the development of these cells.

Home page

http://www.neuro.uoregon.edu/ionmain/htdocs/faculty/eisen.html

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Evaluations

Essential roles of the acetylcholine receptor {gamma}-subunit in neuromuscular synaptic patterning.
Liu Y, Padgett D, …, Green WN, Lin W
Development 2008 Jun 135(11):1957-67 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Judith S. Eisen
Evaluated 3 Jun 2008

Suppression of interneuron programs and maintenance of selected spinal motor neuron fates by the transcription factor AML1/Runx1.
Stifani N, Freitas AR, …, Kania A, Stifani S
Proc Natl Acad Sci U S A 2008 Apr 21 105 [abstract on PubMed] [related articles] [full text]
Selected by | Judith S. Eisen
Evaluated 1 May 2008

Oscillations in notch signaling regulate maintenance of neural progenitors.
Shimojo H, Ohtsuka T, Kageyama R
Neuron 2008 Apr 10 58(1):52-64 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Andy Groves / Judith S. Eisen / Jane Johnson
Evaluated 18 Apr 2008

Molecular separation of two signaling pathways for the receptor, Notch.
Le Gall M, De Mattei C, Giniger E
Dev Biol 2008 Jan 15 313(2):556-67 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Judith S. Eisen
Evaluated 18 Apr 2008

CNS-derived glia ensheath peripheral nerves and mediate motor root development.
Kucenas S, Takada N, …, Broadie K, Appel B
Nat Neurosci 2008 Feb 11(2):143-51 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Judith S. Eisen / Harukazu Nakamura
Evaluated 5 Feb 2008

Position fine-tuning of caudal primary motoneurons in the zebrafish spinal cord.
Sato-Maeda M, Obinata M, Shoji W
Development 2008 Jan 135(2):323-32 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Judith S. Eisen
Evaluated 3 Jan 2008

Light-controlled gene silencing in zebrafish embryos.
Shestopalov IA, Sinha S, Chen JK
Nat Chem Biol 2007 Oct 3(10):650-1 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Lalita Ramakrishnan / Judith S. Eisen
Evaluated 18 Dec 2007

Novel mutations affecting axon guidance in zebrafish and a role for plexin signalling in the guidance of trigeminal and facial nerve axons.
Tanaka H, Maeda R, …, Nakayama R, Okamoto H
Development 2007 Sep 134(18):3259-69 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Judith S. Eisen
Evaluated 18 Dec 2007

Analysis of zebrafish sidetracked mutants reveals a novel role for Plexin A3 in intraspinal motor axon guidance.
Palaisa KA, Granato M
Development 2007 Sep 134(18):3251-7 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Judith S. Eisen
Evaluated 18 Dec 2007

PlexinA3 restricts spinal exit points and branching of trunk motor nerves in embryonic zebrafish.
Feldner J, Reimer MM, …, Becker T, Becker CG
J Neurosci 2007 May 2 27(18):4978-83 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Judith S. Eisen
Evaluated 18 Dec 2007

Target protectors reveal dampening and balancing of Nodal agonist and antagonist by miR-430.
Choi WY, Giraldez AJ, Schier AF
Science 2007 Oct 12 318(5848):271-4 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Judith S. Eisen
Evaluated 12 Nov 2007

Differential Notch signalling distinguishes neural stem cells from intermediate progenitors.
Mizutani K, Yoon K, …, Tokunaga A, Gaiano N
Nature 2007 Sep 20 449(7160):351-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Matthew John Smalley / Judith S. Eisen
Evaluated 22 Oct 2007

Neural crests are actively precluded from the anterior neural fold by a novel inhibitory mechanism dependent on Dickkopf1 secreted by the prechordal mesoderm.
Carmona-Fontaine C, Acuña G, …, Niehrs C, Mayor R
Dev Biol 2007 Sep 15 309(2):208-21 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Kristin Artinger / Judith S. Eisen
Evaluated 12 Oct 2007

Quantitative expression profiling of identified neurons reveals cell-specific constraints on highly variable levels of gene expression.
Schulz DJ, Goaillard JM, Marder EE
Proc Natl Acad Sci U S A 2007 Aug 7 104(32):13187-91 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Judith S. Eisen / Catherine Krull
Evaluated 15 Aug 2007

Repression of the hindbrain developmental program by Cdx factors is required for the specification of the vertebrate spinal cord.
Skromne I, Thorsen D, …, Prince VE, Ho RK
Development 2007 Jun 134(11):2147-58 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Judith S. Eisen
Evaluated 23 Jul 2007

The generation of adipocytes by the neural crest.
Billon N, Iannarelli P, …, Dani C, Dupin E
Development 2007 Jun 134(12):2283-92 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Chaya Kalcheim / Judith S. Eisen
Evaluated 19 Jul 2007

Reduced gap junctional coupling leads to uncorrelated motor neuron firing and precocious neuromuscular synapse elimination.
Personius KE, Chang Q, …, O'Donovan MJ, Balice-Gordon RJ
Proc Natl Acad Sci U S A 2007 Jul 10 104(28):11808-13 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Judith S. Eisen
Evaluated 17 Jul 2007

Molecular architecture of annelid nerve cord supports common origin of nervous system centralization in bilateria.
Denes AS, Jékely G, …, Balavoine G, Arendt D
Cell 2007 Apr 20 129(2):277-88 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Max Telford / James Briscoe / Andrew Lumsden / Judith S. Eisen / Patricia Simpson
Evaluated 16 May 2007

Differential requirement for MuSK and dystroglycan in generating patterns of neuromuscular innervation.
Lefebvre JL, Jing L, …, Franzini-Armstrong C, Granato M
Proc Natl Acad Sci U S A 2007 Feb 13 104(7):2483-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Judith S. Eisen
Evaluated 16 May 2007

Notch and MAML signaling drives Scl-dependent interneuron diversity in the spinal cord.
Peng CY, Yajima H, …, Pfaff SL, Sharma K
Neuron 2007 Mar 15 53(6):813-27 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Jean-François Brunet / Judith S. Eisen
Evaluated 16 May 2007

Notch signaling regulates neural precursor allocation and binary neuronal fate decisions in zebrafish.
Shin J, Poling J, Park HC, Appel B
Development 2007 May 134(10):1911-20 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Judith S. Eisen
Evaluated 16 May 2007

A topographic map of recruitment in spinal cord.
McLean DL, Fan J, …, Hale ME, Fetcho JR
Nature 2007 Mar 1 446(7131):71-5 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Judith S. Eisen
Evaluated 1 May 2007

Peripheral multidendritic sensory neurons are necessary for rhythmic locomotion behavior in Drosophila larvae.
Song W, Onishi M, Jan LY, Jan YN
Proc Natl Acad Sci U S A 2007 Mar 20 104(12):5199-204 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Judith S. Eisen
Evaluated 29 Mar 2007

Cell death of melanophores in zebrafish trpm7 mutant embryos depends on melanin synthesis.
McNeill MS, Paulsen J, …, Hsu MY, Cornell RA
J Invest Dermatol 2007 Aug 127(8):2020-30 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Judith S. Eisen
Evaluated 20 Feb 2007

Axons break in animals lacking beta-spectrin.
Hammarlund M, Jorgensen EM, Bastiani MJ
J Cell Biol 2007 Jan 29 176(3):269-75 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Y. Peng Loh / David Sherwood / Judith S. Eisen / Robert K Herman
Evaluated 19 Feb 2007

Target-induced transcriptional control of dendritic patterning and connectivity in motor neurons by the ETS gene Pea3.
Vrieseling E, Arber S
Cell 2006 Dec 29 127(7):1439-52 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Judith S. Eisen
Evaluated 22 Jan 2007

Activity-dependent neurotransmitter-receptor matching at the neuromuscular junction.
Borodinsky LN, Spitzer NC
Proc Natl Acad Sci U S A 2007 Jan 2 104(1):335-40 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Judith S. Eisen
Evaluated 12 Jan 2007

Primary afferent synapses on developing and adult Renshaw cells.
Mentis GZ, Siembab VC, …, O'Donovan MJ, Alvarez FJ
J Neurosci 2006 Dec 20 26(51):13297-310 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Judith S. Eisen
Evaluated 10 Jan 2007

Increasing the frequency of spontaneous rhythmic activity disrupts pool-specific axon fasciculation and pathfinding of embryonic spinal motoneurons.
Hanson MG, Landmesser LT
J Neurosci 2006 Dec 6 26(49):12769-80 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Judith S. Eisen / Rhona Mirsky
Evaluated 18 Dec 2006

In vivo time-lapse imaging shows dynamic oligodendrocyte progenitor behavior during zebrafish development.
Kirby BB, Takada N, …, Kelsh RN, Appel B
Nat Neurosci 2006 Dec 9(12):1506-11 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Judith S. Eisen / Klaus-Armin Nave
Evaluated 12 Dec 2006

A direct role for Sox10 in specification of neural crest-derived sensory neurons.
Carney TJ, Dutton KA, …, Blader P, Kelsh RN
Development 2006 Dec 133(23):4619-30 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Judith S. Eisen
Evaluated 12 Dec 2006

Olig2-positive progenitors in the embryonic spinal cord give rise not only to motoneurons and oligodendrocytes, but also to a subset of astrocytes and ependymal cells.
Masahira N, Takebayashi H, …, Shimizu K, Ikenaka K
Dev Biol 2006 May 15 293(2):358-69 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Judith S. Eisen
Evaluated 16 Oct 2006

FGF as a target-derived chemoattractant for developing motor axons genetically programmed by the LIM code.
Shirasaki R, Lewcock JW, Lettieri K, Pfaff SL
Neuron 2006 Jun 15 50(6):841-53 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Judith S. Eisen
Evaluated 11 Oct 2006

Wnt signaling inhibitors regulate the transcriptional response to morphogenetic Shh-Gli signaling in the neural tube.
Lei Q, Jeong Y, …, Epstein DJ, Matise MP
Dev Cell 2006 Sep 11(3):325-37 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Judith S. Eisen
Evaluated 11 Oct 2006

Repression of smoothened by patched-dependent (pro-)vitamin D3 secretion.
Bijlsma MF, Spek CA, …, Rezaee F, Peppelenbosch MP
PLoS Biol 2006 Jul 4(8):e232 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jessica E. Treisman / Ed Laufer / Judith S. Eisen / Frank de Gruijl
Evaluated 14 Sep 2006

The myotomal diwanka (lh3) glycosyltransferase and type XVIII collagen are critical for motor growth cone migration.
Schneider VA, Granato M
Neuron 2006 Jun 1 50(5):683-95 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Judith S. Eisen
Evaluated 23 Jun 2006

The chicken talpid3 gene encodes a novel protein essential for Hedgehog signaling.
Davey MG, Paton IR, …, Tickle C, Burt DW
Genes Dev 2006 May 15 20(10):1365-77 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Ivor Mason / Claudio Stern / Judith S. Eisen / Ed Laufer
Evaluated 1 Jun 2006

The timing of cortical neurogenesis is encoded within lineages of individual progenitor cells.
Shen Q, Wang Y, …, Morrisey EE, Temple S
Nat Neurosci 2006 Jun 9(6):743-51 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Susan K. McConnell / Judith S. Eisen / Monte Gates / Arturo Alvarez-Buylla
Evaluated 30 May 2006

Cooperation between GDNF/Ret and ephrinA/EphA4 signals for motor-axon pathway selection in the limb.
Kramer ER, Knott L, …, Helmbacher F, Klein R
Neuron 2006 Apr 6 50(1):35-47 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Ivor Mason / Judith S. Eisen
Evaluated 5 May 2006

Notch1 signaling regulates radial glia differentiation through multiple transcriptional mechanisms.
Patten BA, Sardi SP, …, Nakafuku M, Corfas G
J Neurosci 2006 Mar 22 26(12):3102-8 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Judith S. Eisen
Evaluated 12 Apr 2006

Zebrafish foxd3 is selectively required for neural crest specification, migration and survival.
Stewart RA, Arduini BL, …, Henion PD, Look AT
Dev Biol 2006 Apr 1 292(1):174-88 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Judith S. Eisen
Evaluated 29 Mar 2006

Zebrafish Foxd3 is required for development of a subset of neural crest derivatives.
Lister JA, Cooper C, …, Grant K, Raible DW
Dev Biol 2006 Feb 1 290(1):92-104 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Judith S. Eisen
Evaluated 29 Mar 2006

Hedgehog signalling controls zebrafish neural keel morphogenesis via its level-dependent effects on neurogenesis.
Takamiya M, Campos-Ortega JA
Dev Dyn 2006 Apr 235(4):978-97 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Judith S. Eisen
Evaluated 21 Mar 2006

In vivo imaging of preferential motor axon outgrowth to and synaptogenesis at prepatterned acetylcholine receptor clusters in embryonic zebrafish skeletal muscle.
Panzer JA, Song Y, Balice-Gordon RJ
J Neurosci 2006 Jan 18 26(3):934-47 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Steven Burden / Noam Ziv / Judith S. Eisen
Evaluated 16 Mar 2006

Generality of vertebrate developmental patterns: evidence for a dermomyotome in fish.
Devoto SH, Stoiber W, …, Adiarte EG, Hughes SM
Evol Dev 2006 Jan-Feb 8(1):101-10 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Judith S. Eisen
Evaluated 13 Mar 2006

SLC24A5, a putative cation exchanger, affects pigmentation in zebrafish and humans.
Lamason RL, Mohideen MA, …, Canfield VA, Cheng KC
Science 2005 Dec 16 310(5755):1782-6 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Judith S. Eisen / Carl Thummel / Darryl Nishimura
Evaluated 6 Jan 2006


Neuromuscular synapses can form in vivo by incorporation of initially aneural postsynaptic specializations.
Flanagan-Steet H, Fox MA, Meyer D, Sanes JR
Development 2005 Oct 132(20):4471-81 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Eric Frank / Judith S. Eisen / Noam Ziv
Evaluated 2 Dec 2005

Nrarp functions to modulate neural-crest-cell differentiation by regulating LEF1 protein stability.
Ishitani T, Matsumoto K, Chitnis AB, Itoh M
Nat Cell Biol 2005 Nov 7(11):1106-12 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Chaya Kalcheim / Judith S. Eisen
Evaluated 29 Nov 2005

The basic helix-loop-helix olig3 establishes the neural plate boundary of the trunk and is necessary for development of the dorsal spinal cord.
Filippi A, Tiso N, …, Bortolussi M, Argenton F
Proc Natl Acad Sci U S A 2005 Mar 22 102(12):4377-82 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Judith S. Eisen
Evaluated 29 Nov 2005

Transmembrane protein GDE2 induces motor neuron differentiation in vivo.
Rao M, Sockanathan S
Science 2005 Sep 30 309(5744):2212-5 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Judith S. Eisen
Evaluated 24 Oct 2005

Evolutionary diversification of specification mechanisms within the O/P equivalence group of the leech genus Helobdella.
Kuo DH, Shankland M
Development 2004 Dec 131(23):5859-69 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Judith S. Eisen
Evaluated 24 Oct 2005

Asymmetric Rab 11 endosomes regulate delta recycling and specify cell fate in the Drosophila nervous system.
Emery G, Hutterer A, …, Gaitan MG, Knoblich JA
Cell 2005 Sep 9 122(5):763-73 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Sally Temple / Adam Linstedt / Mark von Zastrow / Judith S. Eisen / Marek Mlodzik
Evaluated 18 Oct 2005

Vertebrate Smoothened functions at the primary cilium.
Corbit KC, Aanstad P, …, Stainier DY, Reiter JF
Nature 2005 Oct 13 437(7061):1018-21 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Judith S. Eisen / Alexandra Joyner
Evaluated 14 Oct 2005

Serotonin signaling is a very early step in patterning of the left-right axis in chick and frog embryos.
Fukumoto T, Kema IP, Levin M
Curr Biol 2005 May 10 15(9):794-803 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Judith S. Eisen
Evaluated 15 Aug 2005

DNER acts as a neuron-specific Notch ligand during Bergmann glial development.
Eiraku M, Tohgo A, …, Hirano T, Kengaku M
Nat Neurosci 2005 Jul 8(7):873-80 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Judith S. Eisen
Evaluated 28 Jul 2005

ATP released via gap junction hemichannels from the pigment epithelium regulates neural retinal progenitor proliferation.
Pearson RA, Dale N, Llaudet E, Mobbs P
Neuron 2005 Jun 2 46(5):731-44 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Carol Mason / Judith S. Eisen
Evaluated 21 Jul 2005

The developmental miRNA profiles of zebrafish as determined by small RNA cloning.
Chen PY, Manninga H, …, Zavolan M, Tuschl T
Genes Dev 2005 Jun 1 19(11):1288-93 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Judith S. Eisen / Sharon Amacher
Evaluated 12 Jul 2005

Zebrafish bandoneon mutants display behavioral defects due to a mutation in the glycine receptor beta-subunit.
Hirata H, Saint-Amant L, …, Granato M, Kuwada JY
Proc Natl Acad Sci U S A 2005 Jun 7 102(23):8345-50 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Judith S. Eisen
Evaluated 11 Jul 2005

Repulsive interactions shape the morphologies and functional arrangement of zebrafish peripheral sensory arbors.
Sagasti A, Guido MR, Raible DW, Schier AF
Curr Biol 2005 May 10 15(9):804-14 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Catherine Krull / Judith S. Eisen / Ellen A. Lumpkin
Evaluated 14 Jun 2005

erbb3 and erbb2 are essential for schwann cell migration and myelination in zebrafish.
Lyons DA, Pogoda HM, …, Jacobs J, Talbot WS
Curr Biol 2005 Mar 29 15(6):513-24 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Lilianna Solnica-Krezel / Judith S. Eisen
Evaluated 27 May 2005

Mammalian motor neurons corelease glutamate and acetylcholine at central synapses.
Nishimaru H, Restrepo CE, …, Yanagawa Y, Kiehn O
Proc Natl Acad Sci U S A 2005 Apr 5 102(14):5245-9 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Jan-Marino Ramirez / Judith S. Eisen
Evaluated 9 May 2005

Coexpressed EphA receptors and ephrin-A ligands mediate opposing actions on growth cone navigation from distinct membrane domains.
Marquardt T, Shirasaki R, …, Hunter T, Pfaff SL
Cell 2005 Apr 8 121(1):127-39 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Chaya Kalcheim / Judith S. Eisen / Paola Chiarugi / Catherine Krull / David Wilkinson
Evaluated 21 Apr 2005

Sonic hedgeho